Patents by Inventor Chengang Zhou

Chengang Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic compounds
    Patent number: 11858912
    Abstract: The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X, D, R1 to R4, and R6 to R10 are as described herein. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Grant
    Filed: July 14, 2022
    Date of Patent: January 2, 2024
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Mathis Braendlin, Sandra Marie Joseph Grall-Ulsemer, Xingchun Han, Christian Lerner, Mingming Li, Yongqiang Liu, Sébastien Schmitt, Jianhua Wang, Yongguang Wang, Min Wang, Song Yang, Chengang Zhou
  • HETEROARYL-SUBSTITUTED IMIDAZOLE DERIVATIVES
    Publication number: 20230373978
    Abstract: The invention provides novel heteroaryl-substituted imidazole derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein A and R1 to R6 are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: August 1, 2023
    Publication date: November 23, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Christian LERNER, Mingming LI, Yongqiang LIU, Jianhua WANG, Min WANG, Yongguang WANG, Song YANG, Chengang ZHOU
  • NOVEL IMIDAZOLE-PYRAZOLE DERIVATIVES
    Publication number: 20230295123
    Abstract: The invention provides novel imidazole pyrazole derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein R1-R7 are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: February 28, 2023
    Publication date: September 21, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Christian LERNER, Mingming LI, Yongqiang LIU, Sébastien SCHMITT, Jianhua WANG, Min WANG, Yongguang WANG, Song YANG, Chengang ZHOU
  • NOVEL HETEROCYCLIC COMPOUNDS
    Publication number: 20230257354
    Abstract: The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R9 and p are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: March 6, 2023
    Publication date: August 17, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhanling CHENG, Christian LERNER, Yongqiang LIU, Matthias NETTEKOVEN, Philippe PFLIEGER, Bernd PUELLMANN, Jianhua WANG, Min WANG, Yongguang WANG, Song YANG, Chengang ZHOU
  • IMIDAZOLE-PYRAZOLE DERIVATIVES AS ANTIBACTERIALS
    Publication number: 20230234939
    Abstract: The invention provides novel imidazole pyrazole derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein A and R1-R7 are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: February 27, 2023
    Publication date: July 27, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Sandra Marie Joseph GRALL-ULSEMER, Wolfgang GUBA, Christian LERNER, Mingming LI, Yongqiang LIU, Markus RUDOLPH, Sébastien SCHMITT, Lorenz URNER, Yongguang WANG, Min WANG, Jianhua WANG, Song YANG, Chengang ZHOU, Patrizio MATTEI
  • NOVEL IMIDAZOPYRAZINE DERIVATIVES
    Publication number: 20230203043
    Abstract: The invention provides novel imidazopyrazine derivatives having the general formula (I), or pharmaceutically acceptable salts thereof, wherein X and R3 to R9 are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: October 28, 2022
    Publication date: June 29, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Jean-Baptiste BLANC, Christian LERNER, Matthias NETTEKOVEN, Philippe PFLIEGER, Bernd PUELLMANN, Sébastien SCHMITT, Theodor STOLL, Song YANG, Chengang ZHOU
  • NOVEL IMIDAZOPYRAZNE DERIVATIVES
    Publication number: 20230203047
    Abstract: The invention provides novel imidazopyrazine derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X1 to X4, R1 to R5, R8 to R10, A, and L1 are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: November 29, 2022
    Publication date: June 29, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Christian LERNER, Yongqiang LIU, Song YANG, Chengang ZHOU
  • IMIDAZOPYRAZINE DERIVATIVES
    Publication number: 20230141600
    Abstract: The invention provides novel imidazopyrazine derivatives having the general formula (I), wherein Rx and R3 to R5 are as described herein: or pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: December 6, 2022
    Publication date: May 11, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhanling CHENG, Christian KRAMER, Christian LERNER, Yongqiang LIU, Matthias NETTEKOVEN, Philippe PFLIEGER, Sébastien SCHMITT, Theodor STOLL, Jianhua WANG, Yongguang WANG, Song YANG, Chengang ZHOU
  • NOVEL HETEROCYCLIC COMPOUNDS
    Publication number: 20230133845
    Abstract: The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X, D, R1 to R4, and R6 to R10 are as described herein. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: July 14, 2022
    Publication date: May 4, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Mathis BRAENDLIN, Sandra Marie Joseph GRALL-ULSEMER, Xingchun HAN, Christian LERNER, Mingming LI, Yongqiang LIU, Sébastien SCHMITT, Jianhua WANG, Yongguang WANG, Min WANG, Song YANG, Chengang ZHOU
  • NOVEL HETEROCYCLIC COMPOUNDS
    Publication number: 20220396565
    Abstract: Provided are novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R4, m, n, and p are as described herein. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: July 20, 2022
    Publication date: December 15, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhanling CHENG, Xingchun HAN, Christian KRAMER, Christian LERNER, Yongqiang LIU, Matthias NETTEKOVEN, Philippe PFLIEGER, Bernd PUELLMANN, Jianhua WANG, Lisha WANG, Min WANG, Yongguang WANG, Song YANG, Chengang ZHOU
  • Imidazole-pyrazole derivatives
    Patent number: 11390604
    Abstract: The disclosure provides novel imidazole pyrazole derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X1, RA and R3 to R7 are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: July 19, 2022
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean-Baptiste Blanc, Christian Kramer, Christian Lerner, Matthias Nettekoven, Philippe Pflieger, Bernd Puellmann, Thomas Ryckmans, Sébastien Schmitt, Min Wang, Song Yang, Chengang Zhou
  • FREE AMINO COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION
    Publication number: 20210323981
    Abstract: The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: May 20, 2021
    Publication date: October 21, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Hong SHEN, Xuefei TAN, Chengang ZHOU, Mingwei ZHOU, Yimin HU, Houguang SHI, Fabian DEY, Yongqiang LIU, Xiao DING
  • OXOPYRIDO[1,2-A]PYRIMIDINE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION
    Publication number: 20210317141
    Abstract: The present invention relates to novel compounds of formula (I), wherein R1 to R7 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: June 17, 2021
    Publication date: October 14, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Fabian DEY, Xiao DING, Yimin HU, Yongqiang LIU, Hong SHEN, Honguang SHI, Xuefei TAN, Chengang ZHOU, Mingwei ZHOU
  • ARYL COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION
    Publication number: 20210309658
    Abstract: The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: May 26, 2021
    Publication date: October 7, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Fabian DEY, Yimin HU, Yongqiang LIU, Hong SHEN, Houguang SHI, Xuefei TAN, Shixiang YAN, Weixing ZHANG, Zhiwei ZHANG, Chengang ZHOU, Mingwei ZHOU, Wei ZHU
  • TRICYCLIC COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION
    Publication number: 20210309657
    Abstract: The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: May 26, 2021
    Publication date: October 7, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Fabian DEY, Yimin HU, Yongqiang LIU, Hong SHEN, Houguang SHI, Xuefei TAN, Shixiang YAN, Weixing ZHANG, Zhiwei ZHANG, Chengang ZHOU, Mingwei ZHOU, Wei ZHU
  • NOVEL OXOQUINOLIZINE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION
    Publication number: 20210238197
    Abstract: The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5, R6 and R7 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: November 25, 2020
    Publication date: August 5, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Fabian Dey, Xiao Ding, Yimin Hu, Yongqiang Liu, Hong Shen, Houguang Shi, Xuefei Tan, Chengang Zhou, Mingwei Zhou
  • SUBSTITUTED PYRIDOINDOLES FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION
    Publication number: 20210221832
    Abstract: The present invention relates to novel compounds of formula (I) or (II), wherein R1 to R6, R11 to R17 are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: March 25, 2021
    Publication date: July 22, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Xiao DING, Yongqiang LIU, Hong SHEN, Houguang SHI, Xuefei TAN, Chengang ZHOU, Mingwei ZHOU
  • Novel pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection
    Publication number: 20200339603
    Abstract: The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: April 29, 2020
    Publication date: October 29, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Yimin Hu, Chengang Zhou, Mingwei Zhou, Houguang Shi, Yongqiang Liu, Hong Shen, Maarten Vercruysse, Shixiang Yan, Xuefei Tan, Xianfeng Lin, Fabian Dey
  • NOVEL IMIDAZOLE-PYRAZOLE DERIVATIVES
    Publication number: 20200290998
    Abstract: The disclosure provides novel imidazole pyrazole derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X1, RA and R3 to R7 are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: March 6, 2020
    Publication date: September 17, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Jean-Baptiste Blanc, Christian Kramer, Christian Lerner, Matthias Nettekoven, Philippe Pflieger, Bernd Puellmann, Thomas Ryckmans, Sébastien Schmitt, Min Wang, Song Yang, Chengang Zhou
  • Pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection
    Patent number: 10662203
    Abstract: The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: May 26, 2020
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Yimin Hu, Chengang Zhou, Mingwei Zhou, Houguang Shi, Yongqiang Liu, Hong Shen, Maarten Vercruysse, Shixiang Yan, Xuefei Tan, Xianfeng Lin, Fabian Dey