Abstract: An engineered radioactive polymeric microsphere, and a preparation and application thereof. The preparation method includes: adding a styrene monomer and a disperser and/or a crosslinker into a medium, followed by feeding of nitrogen or helium and stirring to obtain a first reaction mixture; heating the first reaction mixture, and adding an initiator, followed by reaction under stirring at a constant temperature to obtain a second reaction mixture; subjecting the second reaction mixture to washing with ethanol and water, and vacuum drying to obtain a crude polymeric microsphere; subjecting the crude polymeric microsphere to radiation-induced graft polymerization with a functional monomer to obtain the functionalized polymeric microsphere; and exposing the functionalized polymeric microsphere to a radionuclide to prepare the engineered radioactive polymeric microsphere.

Abstract: An engineered radioactive polymeric microsphere, and a preparation and application thereof. The preparation method includes: adding a styrene monomer and a disperser and/or a crosslinker into a medium, followed by feeding of nitrogen or helium and stirring to obtain a first reaction mixture; heating the first reaction mixture, and adding an initiator, followed by reaction under stirring at a constant temperature to obtain a second reaction mixture; subjecting the second reaction mixture to washing with ethanol and water, and vacuum drying to obtain a crude polymeric microsphere; subjecting the crude polymeric microsphere to radiation-induced graft polymerization with a functional monomer to obtain the functionalized polymeric microsphere; and exposing the functionalized polymeric microsphere to a radionuclide to prepare the engineered radioactive polymeric microsphere.

Abstract: Disclosed is a method of preparing a drug-iodinated oil dispersion by high-pressure dissolution. In the invention, drug molecules are dissolved in and thoroughly mixed with iodinated oil under high pressure and rapid stirring. After the depressurization, the drug molecules are dispersed in the iodinated oil to prepare a uniformly-mixed drug-iodinated oil dispersion. The drug-iodinated oil dispersion prepared herein, compared to the drug-iodinated oil suspension and emulsion, has advantages of controllable morphology, long-term stability and slow drug-releasing rate, moreover, the drug molecules do not negatively affect the iodinated oil in physicochemical properties such as viscosity. In the liver cancer treatment, the prepared drug-iodinated oil dispersion is firstly injected through the hepatic arteries to perform the embolization, and the drug molecules are slowly released for a sustained treatment. The invention provides a good reference for the therapy combined with iodinated oil embolization.