Abstract: The present invention belongs to the technical field of biomedicine, and mainly relates to a miR-7-5p mimic for inhibiting migration and invasion of breast cancer, a screening method and an application thereof. The sequence of the miR-7-5p is shown in SEQ ID NO.1. The present invention has found that the miR-7-5p mimic generates a significant inhibitory effect on breast cancer through targeted inhibition of the molecular mechanism of RYK. In vitro culture system, the miR-7-5p mimic can function to inhibit migration and invasion capabilities of breast cancer. The miR-7-5p mimic can inhibit RYK protein and mRNA levels in breast cancer. In nude mice, the miR-7-5p mimic can also significantly inhibit migration and invasion capabilities of breast cancer. Therefore, the present invention demonstrates that the miR-7-5p mimic can be a small-nucleic-acid drug to significantly inhibit breast cancer metastasis.

Abstract: A radially polarized optical parametric amplifier insensitive to polarization is provided by the present invention, which comprises a laser module and a nonlinear crystal satisfying the type-II phase matching or the type-II quasi-phase matching condition, wherein the laser module is configured to generate two laser beams, namely the pump light and the signal light with an arbitrary polarization state, the wavelengths of the pump light and the signal light are degenerate or nearly degenerate; and the nonlinear crystal is provided in the emergent beamline of the laser module to perform optical parametric amplification of the signal light by using the pump light.

Abstract: The present disclosure relates to a broadband optical parametric chirped pulse amplifier insensitive to temperature comprises the first pulsed laser, the second pulsed laser, a pulse stretcher and a periodically poled nonlinear crystal. Via the proper arrangement of the non-collinear angles between the transmission directions of the signal light, the pump light and the idler light, to simultaneously satisfy the angular relationship required for constructing the non-collinear phase-matching configuration insensitive to wavelength and that required for constructing the non-collinear phase-matching configuration insensitive to temperature, the optical parametric chirped pulse amplifier not only can realize a broadband parametric amplification of the signal light (insensitive to wavelength), but also can effectively alleviate the phase mismatch in nonlinear crystal resulted from the excessively high local temperature (insensitive to temperature).

Abstract: The present disclosure relates to a broadband optical parametric chirped pulse amplifier insensitive to temperature comprises the first pulsed laser, the second pulsed laser, a pulse stretcher and a periodically poled nonlinear crystal. Via the proper arrangement of the non-collinear angles between the transmission directions of the signal light, the pump light and the idler light, to simultaneously satisfy the angular relationship required for constructing the non-collinear phase-matching configuration insensitive to wavelength and that required for constructing the non-collinear phase-matching configuration insensitive to temperature, the optical parametric chirped pulse amplifier not only can realize a broadband parametric amplification of the signal light (insensitive to wavelength), but also can effectively alleviate the phase mismatch in nonlinear crystal resulted from the excessively high local temperature (insensitive to temperature).