Abstract: The present invention provides Wnt pathway agonists and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of diseases.

Abstract: An anti-FGFR2 antibody, an encoding nucleic acid of the antibody, a vector and host cell for the expression and production thereof, an antibody-drug conjugate, and a pharmaceutical composition comprising the antibody. The present invention further relates to the use of the antibody molecule in a drug for diagnosing a cancer caused by FGFR2-pathway-related dysregulation, and the use of the antibody or antibody-drug conjugate in the preparation of a medicament for treating a cancer caused by FGFR2-pathway-related dysregulation, in particular gastric cancer.

Abstract: An electrically conductive, flexible, strain resilient product is produced by mixing metal coated carbon nanotube networks with a liquid polymeric resin to produce a liquid mixture, and the mixture is cured to produce the product. The networks may include welded junctions between nanotubes formed by depositing and melting metal nanoparticles on the nanotubes to form the metal coating. After the mixing step the liquid mixture may be deposited on a flexible substrate in the form of an electrical circuit. The mixing step may further include mixing the composite with a volatile solvent to produce a selected viscosity. Then, a three-dimensional printer may be used to print the product, such as an electrical circuit, on a substrate. The product is cured in an atmosphere that absorbs the solvent. The conductivity of the mixture may be adjusted by adjusting the weight percentage of the metal coated carbon nanotube networks from 50% to 90%, but a preferred range is between 75% and 85%.

Abstract: An electrically conductive, flexible, strain resilient product is produced by mixing metal coated carbon nanotube networks with a liquid polymeric resin to produce a liquid mixture, and the mixture is cured to produce the product. The networks may include welded junctions between nanotubes formed by depositing and melting metal nanoparticles on the nanotubes to form the metal coating. After the mixing step the liquid mixture may be deposited on a flexible substrate in the form of an electrical circuit. The mixing step may further include mixing the composite with a volatile solvent to produce a selected viscosity. Then, a three-dimensional printer may be used to print the product, such as an electrical circuit, on a substrate. The product is cured in an atmosphere that absorbs the solvent. The conductivity of the mixture may be adjusted by adjusting the weight percentage of the metal coated carbon nanotube networks from 50% to 90%, but a preferred range is between 75% and 85%.

Abstract: An electrically conductive, flexible, strain resilient product is produced by mixing metal coated carbon nanotube networks with a liquid polymeric resin to produce a liquid mixture, and the mixture is cured to produce the product. The networks may include welded junctions between nanotubes formed by depositing and melting metal nanoparticles on the nanotubes to form the metal coating. After the mixing step the liquid mixture may be deposited on a flexible substrate in the form of an electrical circuit. The mixing step may further include mixing the composite with a volatile solvent to produce a selected viscosity. Then, a three-dimensional printer may be used to print the product, such as an electrical circuit, on a substrate. The product is cured in an atmosphere that absorbs the solvent. The conductivity of the mixture may be adjusted by adjusting the weight percentage of the metal coated carbon nanotube networks from 50% to 90%, but a preferred range is between 75% and 85%.

Abstract: An electrically conductive, flexible, strain resilient product is produced by mixing metal coated carbon nanotube networks with a liquid polymeric resin to produce a liquid mixture, and the mixture is cured to produce the product. The networks may include welded junctions between nanotubes formed by depositing and melting metal nanoparticles on the nanotubes to form the metal coating. After the mixing step the liquid mixture may be deposited on a flexible substrate in the form of an electrical circuit. The mixing step may further include mixing the composite with a volatile solvent to produce a selected viscosity. Then, a three-dimensional printer may be used to print the product, such as an electrical circuit, on a substrate. The product is cured in an atmosphere that absorbs the solvent. The conductivity of the mixture may be adjusted by adjusting the weight percentage of the metal coated carbon nanotube networks from 50% to 90%, but a preferred range is between 75% and 85%.

Abstract: An electrically conductive, flexible, strain resilient product is produced by mixing metal coated carbon nanotube networks with a liquid polymeric resin to produce a liquid mixture, and the mixture is cured to produce the product. The networks may include welded junctions between nanotubes formed by depositing and melting metal nanoparticles on the nanotubes to form the metal coating. After the mixing step the liquid mixture may be deposited on a flexible substrate in the form of an electrical circuit. The mixing step may further include mixing the composite with a volatile solvent to produce a selected viscosity. Then, a three-dimensional printer may be used to print the product, such as an electrical circuit, on a substrate. The product is cured in an atmosphere that absorbs the solvent. The conductivity of the mixture may be adjusted by adjusting the weight percentage of the metal coated carbon nanotube networks from 50% to 90%, but a preferred range is between 75% and 85%.

Abstract: Light-weight hybrid materials with significantly-reduced coefficient of thermal expansion, low density, and high durability in the aggressive environment such as low-earth orbit are disclosed. The high performance polymer materials can include epoxy, cyanoester, bismalmeide, polyimide, vinylester, polyamide, polyacrylate, and others; with their applications as matrix in the carbon fiber-reinforced or glass fiber-reinforced composite. The fillers for the hybrid include one or two or all, of the following components: the layered-silicate, negative-CTE powder, and low-density material.

Abstract: A method of making a polymeric nanocomposite material. The method includes combining nanosize materials, such as layered silicates, or tube-silicates, with a thermosetting polymer and a solvent to form a substantially homogeneous mixture, removing the solvent, adding a curing agent, and ultrasonicating the mixture.

Abstract: A method of making a polymeric nanocomposite material. The method includes combining nanosize materials, such as layered silicates, or nanosize sphered silica, with a polymer and a solvent to form a substantially homogeneous mixture, followed by removal of the solvent. The method forms a layered-silicate nanocomposite with an intercalated nanostructure with very large interplanar spacing or a combination of intercalated and exfoliated nanostructure.

Abstract: A method of making a nanocomposite having homogeneously dispersed individual nanosize spherical silica particles. The invention also involves a method of making a nancomposite having homogeneously dispersed small aggregated nanosize spherical silica particles.

Abstract: Articles of manufacture, such as bulk composites, composite coatings, and composite films, can be prepared by exposing a gel to air, and allowing it to stand at room temperature to cure. The gel is obtained by mixing an organopolysiloxane sheet or tube polymer with an alkoxysilane. Organopolysiloxane sheet or tube polymers are obtained by contacting sheet or tube silicates with an organohalosilane and a solvent, and heating the mixture.

Abstract: Gels, cast films, coatings, extruded rods, extruded fibers, compression molded discs, and machined compression molded discs, are made from organopolysiloxane sheet or tube polymers such as an apophyllite-derived 3-cyanopropyldimethyl siloxy sheet polymer of the formula [((NCC.sub.3 H.sub.6)(CH.sub.3).sub.2 SiO).sub.x (HO).sub.1-x SiO.sub.1.5 ].sub.n. Polymers are prepared by contacting sheet or tube silicates with an organohalosilane containing at least one polar group such as cyanoalkyl, acyloxy, or haloalkyl, in the presence of a polar solvent or a mixture of a polar solvent and a non-polar solvent; and heating the mixture until a polymer is formed.

Abstract: A method for synthesizing an apophyllite-derived 3-cyanopropyldimethylsiloxy-5-hexenyldimethylsiloxy sheet polymer (A-CM.sub.2 -HEM.sub.2); an apophyllite-derived 3-cyanopropyldimethylsiloxy-vinyldimethylsiloxy sheet polymer (A-CM.sub.2 -VM.sub.2); and an apophyllite-derived 3-cyanopropyldimethylsiloxy-n-decyldimethylsiloxy sheet polymer (A-CM.sub.2 -DM.sub.2). These polymers form gels with simple polar solvents such as acetone and therefore can be easily processed. The first two of the polymers, i.e., A-CM.sub.2 -HEM.sub.2 and A-CM.sub.2 -VM.sub.2, form gels with polar solvents carrying olefinic linkages, and these gels can be crosslinked into sheet composites having fully exfoliated organosilicon sheets in an organic matrix.

Abstract: A method of making an organopolysiloxane sheet or tube polymer involves contacting a sheet or tube silicate with an organo-H-chlorosilane to form an organosiloxane sheet or tube polymer with pendent .tbd.Si--H groups. Subsequently, the organosiloxane sheet or tube polymer with pendent .tbd.Si--H groups is contacted with an alkenyl group containing compound in the presence of a hydrosilation catalyst. The catalyst is used in an amount effective to catalyze a hydrosilation reaction between the alkenyl group on the alkenyl group containing compound and the hydride functionality on the organosiloxane sheet or tube polymer with pendent .tbd.