Abstract: A layered, microfluidic array is disclosed. The array has a first layer with a culture channels extending in a first longitudinal direction. Each culture channel includes multiple traps that entrap cell or tissue samples. The array also has a second layer with microfluidic channels extending in a second longitudinal direction that is orthogonal the first longitudinal direction. A third layer, disposed between the first layer and the second layer, has pores arranged within the third layer such that each nest is vertically stacked above, and fluidly connected with, a corresponding culture chamber in the first layer. Each nest is fluidly isolated from adjacent nests by a fluid impermeable region of the third layer such that horizontal diffusion of water within the third layer is prevented.

Abstract: A layered, microfluidic array is disclosed. The array has a first layer with a culture channels extending in a first longitudinal direction. Each culture channel includes multiple traps that entrap cell or tissue samples. The array also has a second layer with microfluidic channels extending in a second longitudinal direction that is orthogonal the first longitudinal direction. A third layer, disposed between the first layer and the second layer, has pores arranged within the third layer such that each nest is vertically stacked above, and fluidly connected with, a corresponding culture chamber in the first layer. Each nest is fluidly isolated from adjacent nests by a fluid impermeable region of the third layer such that horizontal diffusion of water within the third layer is prevented.

Abstract: The present invention relates to a cholic acid derivative, and a preparation method and a medical use thereof. In particular, the present invention relates to a cholic acid derivative of formula (I), a stereoisomer, or a pharmaceutically acceptable salt thereof. The series of compounds can be used to treat FXR mediated diseases, including cardiovascular disease, atherosclerosis, arteriosclerosis, hypercholesterolemia, hyperlipidemia and chronic hepatitis diseases, chronic liver diseases, gastrointestinal diseases, nephrosis, heart vascular diseases, metabolic diseases, cancer (for example colorectal cancer) or neurological diseases, such as strokes and other diseases, with a wide range of medical applications, and are expected to develop into a new generation of FXR agonists.

Abstract: A layered, microfluidic array is disclosed. The array comprises a first layer comprising at least one culture channel; a second layer comprising at least one microfluidic channel; and a third layer, disposed between the first layer and the second layer. The third layer comprises a filter membrane with a plurality of pores, each pore fluidly connecting the microfluidic channel to the culture channel.

Abstract: A road network is described using roads, intersections and sections as traffic information elements and a correspondence between these elements and a road topological network in a digital map is established, so that a universal traffic information describing model, which is compatible with language used in people's daily life, can be established. The traffic information element knowledge base is generated based on roads, intersections and sections, respective attributes and the relationship between them, to support inter-conversion between road topological network traffic information and text-based traffic information.

Abstract: A device for recognizing user behavior is provided, which includes: a position data receiving unit configured to receive user position data and adjust the data based on time to obtain user position data in time series; a data pretreating unit configured to pretreat the user position data in time series; a feature vector extracting unit configured to extract a feature vector for recognizing a type of a user activity according to the pretreated user position data; and a user behavior recognizing unit configured to recognize the type of a user activity according to the feature vector extracted by the feature vector extracting unit and to obtain behavior features of the user. A method for recognizing user behavior is also provided. Deep level behavior features of the user can be obtained, such that the recognition result for each user can be more accurate and richer.

Abstract: A method and apparatus for conversion of traffic information based on traffic information element knowledge base are provided. According to the present invention, a road network is described using roads, intersections and sections as traffic information elements and a correspondence between these elements and a road topological network in a digital map is established, so that a universal traffic information describing model, which is compatible with language used in people's daily life, can be established. Further, a traffic information element knowledge base can be generated based on the roads, intersections and sections, their respective attributes and the relationship between them, to support inter-conversion between road topological network traffic information and text-based traffic information.

Abstract: A method and apparatus for representing a road network and a method and system for processing traffic information data using the method for representing a road network are provided. The method for processing traffic information data comprises: conversion step of converting traffic information data based on road networks of one or more types of road maps into traffic information data of intersections and sections, based on correspondence between the road networks of one or more types of road maps and the road network represented by the intersections and the sections, wherein the road network represented by the intersections and the sections is obtained by the method for representing a road network; and fusion step of fusing the converted traffic information data of intersections and sections to obtain unified traffic information data.