Abstract: The present disclosure is related to systems and methods for noise reduction. The method includes obtaining a current frame including a plurality of first pixels. The method includes determining an interframe difference between each first pixel in the current frame and a corresponding pixel in a previous frame obtained prior to the current frame. The method includes generating a denoised frame by performing a first noise reduction operation on the current frame. The method includes determining an intraframe difference for each second pixel in the denoised frame. The method includes generating a target frame by performing a second noise reduction operation on the denoised frame.