Abstract: Manganese-doped hollow mesoporous silica nanoparticles loaded with curcumin and an application in periodontal bone tissue repair are provided in the present disclosure, belonging to the technical field of targeted delivery of nanoparticles and bone tissue regeneration. In the present disclosure, alendronate is grafted on the surface of silica nanoparticles to achieve bone targeting, manganese is doped on the nanoparticles by a chemical method, and curcumin is wrapped in the nanoparticles.

Abstract: Manganese-doped hollow mesoporous silica nanoparticles loaded with curcumin and an application in periodontal bone tissue repair are provided in the present disclosure, belonging to the technical field of targeted delivery of nanoparticles and bone tissue regeneration. In the present disclosure, alendronate is grafted on the surface of silica nanoparticles to achieve bone targeting, manganese is doped on the nanoparticles by a chemical method, and curcumin is wrapped in the nanoparticles.

Abstract: Provided are a drill-power-based directional hydraulic fracturing system for downhole quick slotting and a method thereof. The directional hydraulic fracturing system includes a water injection pump, a high pressure rubber pipe arranged on the water injection pump is in communication with a drill, a dedicated sealing drill rod for hydraulic fracturing is arranged on the drill, a front segment of the drill rod may be connected with a directional borehole sealer through threads and a sealing ring is provided at the threaded connection. The main steps include drilling, slotting, borehole sealing and fracturing. Firstly, a drill-cut integrated tool is installed at a front end of the drill rod. After drilling is completed, hydraulic slotting, permeability improvement and pressure relief are performed without changing a drill bit. After slotting is completed, the drill bit is retreated, and the directional borehole sealer is installed and pushed to a predetermined position for efficiency sealing.

Abstract: Provided are a drill-power-based directional hydraulic fracturing system for downhole quick slotting and a method thereof. The directional hydraulic fracturing system includes a water injection pump, a high pressure rubber pipe arranged on the water injection pump is in communication with a drill, a dedicated sealing drill rod for hydraulic fracturing is arranged on the drill, a front segment of the drill rod may be connected with a directional borehole sealer through threads and a sealing ring is provided at the threaded connection. The main steps include drilling, slotting, borehole sealing and fracturing. Firstly, a drill-cut integrated tool is installed at a front end of the drill rod. After drilling is completed, hydraulic slotting, permeability improvement and pressure relief are performed without changing a drill bit. After slotting is completed, the drill bit is retreated, and the directional borehole sealer is installed and pushed to a predetermined position for efficiency sealing.