Abstract: The present disclosure, at least in part, provides methods for regulating Blood-Central Nervous System (blood-CNS) barrier permeability (e.g., increasing or decreasing Blood-CNS barrier permeability) by regulating signaling between pericyte derived vitronectin and integrin expressed on CNS endothelial cells (e.g., integrin ?5). In some aspects, the present disclosure also provides a Blood-Central Nervous System (blood-CNS) barrier model comprising CNS endothelial cells and vitronectin or a plurality of cells secreting vitronectin, and methods for producing the same.

Abstract: A connecting device for connecting to a focusing lens or an aiming lens includes a frame detachably connected to an external device and including an installing member for fixing with a lens, and a fastening member for connecting the frame with the external device. The fastening member includes at least one group of wedge-shaped pair members engaged with each other and an adjusting device for driving two components with the at least one group of wedge-shaped pair members to slide relatively to the external device so that the frame can be tightly fixed with the external device. The frame can be tightly and reliably fixed with a guiding slider via the wedge-shaped pair member when they are locked to each other, and the adjusting device is provided for conveniently adjusting or locking the frame and the guiding slider so that the installation or disassembly of the frame can be conveniently obtained.

Abstract: A connecting device for connecting to a focusing lens or an aiming lens includes a frame detachably connected to an external device and including an installing member for fixing with a lens, and a fastening member for connecting the frame with the external device. The fastening member includes at least one group of wedge-shaped pair members engaged with each other and an adjusting device for driving two components with the at least one group of wedge-shaped pair members to slide relatively to the external device so that the frame can be tightly fixed with the external device. The frame can be tightly and reliably fixed with a guiding slider via the wedge-shaped pair member when they are locked to each other, and the adjusting device is provided for conveniently adjusting or locking the frame and the guiding slider so that the installation or disassembly of the frame can be conveniently obtained.

Abstract: Described herein are methods and compositions relating to modulating the permeability of the blood-brain barrier, e.g. increasing or decreasing the permeability of the blood-brain barrier for therapeutic purposes.