Patents by Inventor Chengjun Huang
Chengjun Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210139493Abstract: The present invention relates to a preparation method for velpatasvir and a derivative thereof. Specifically, in the present invention, velpatasvir and the derivative thereof is prepared by means of an intermediate compound represented by the following formula (definitions of the groups are described in the specifications). By means of the method, byproducts are fewer, costs are low, and the method is applicable to industrial production of velpatasvir.Type: ApplicationFiled: February 27, 2018Publication date: May 13, 2021Inventors: Shaojun FU, Chengjun HUANG, Yi REN, Wei LI
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Patent number: 10330580Abstract: A microfluidic magnetic selector comprises a microfluidic channel comprising at least one bifurcation, forming a selection portion of the selector and splitting the microfluidic channel into a main channel and at least one selection channel; at least one magnetic flux concentrator for concentrating a magnetic flux at the level of the bifurcation, and means for generating a magnetic field within the magnetic flux concentrator, and a controller for controlling magnetic pulses through the magnetic flux concentrator.Type: GrantFiled: June 10, 2016Date of Patent: June 25, 2019Assignee: IMEC VZWInventors: Richard Min, Liesbet Lagae, Chengxun Liu, Chengjun Huang
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Patent number: 10294219Abstract: The present invention relates to a novel Ledipasvir (LDV) crystal form and a preparation method thereof. Specifically, disclosed is an LDV solvate. The solvate is a solvate formed by LDV and a solvent A and/or a solvent B, wherein the solvent A is acetonitrile or acetone; and the solvent B is methyl tertiary butyl ether (MTBE). Also disclosed are a preparation method and an application of the solvate. The solvate has a high purity, a good crystallization property, and better optical stability. The preparation method is simple and the process is stable. The solvate can significantly improve quality control and industrial applications of LDV-containing drugs.Type: GrantFiled: June 24, 2016Date of Patent: May 21, 2019Assignee: SHANGHAI FOREFRONT PHARMACEUTICAL CO., LTD.Inventors: Wei Li, Yi Ren, Chengjun Huang, Yanyan Zhu, Shaojun Fu, Gang Fu, Zhewen Wei
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Patent number: 10119898Abstract: A particle screening device is provided. The particle screening device comprises: a substrate including a first side and a second side opposite to the first side; a micropore array formed on the substrate, wherein each micropore penetrates through the substrate from the first side to the second side and has a size configured to at least permit particles smaller than target particles flow through; and electrodes formed on at least one side of the first and second sides of the substrate and around at least some micropores, wherein the electrodes are configured to generate an electric field at corresponding micropores.Type: GrantFiled: June 24, 2015Date of Patent: November 6, 2018Assignee: Pixel Biotech (Shanghai) Co., Ltd.Inventors: Chengjun Huang, Jun Luo, Chao Zhao
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Publication number: 20180194752Abstract: The present invention relates to a novel Ledipasvir (LDV) crystal form and a preparation method thereof. Specifically, disclosed is an LDV solvate. The solvate is a solvate formed by LDV and a solvent A and/or a solvent B, wherein the solvent A is acetonitrile or acetone; and the solvent B is methyl tertiary butyl ether (MTBE). Also disclosed are a preparation method and an application of the solvate. The solvate has a high purity, a good crystallization property, and better optical stability. The preparation method is simple and the process is stable. The solvate can significantly improve quality control and industrial applications of LDV-containing drugs.Type: ApplicationFiled: June 24, 2016Publication date: July 12, 2018Inventors: Wei LI, Yi REN, Chengjun HUANG, Yanyan ZHU, Shaojun FU, Gang FU, Zhewen WEI
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Publication number: 20180079744Abstract: Methods of preparing Ledipasvir and derivatives thereof, and intermediate compounds used in the preparation of Ledipasvir are provided. Specifically, a method for preparing the compounds of formula 1 and a series of preparation methods of preparing Ledipasvir are provided. The methods described herein are simple and efficient, and have better application prospects.Type: ApplicationFiled: March 2, 2016Publication date: March 22, 2018Inventors: Chengjun HUANG, Gang FU, Shaojun FU, Zhewen WEI, Wei LI, Xixuan ZHANG
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Publication number: 20180045667Abstract: A sensing device is disclosed. The sensing device comprises: a first electrode layer, a second electrode layer, which are separated by a dielectric layer; and through holes penetrating through the first electrode layer, the second electrode layer and the dielectric layer.Type: ApplicationFiled: August 3, 2015Publication date: February 15, 2018Inventors: Chengjun Huang, Jun Luo, Chao Zhao
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Patent number: 9833781Abstract: An example micro-fluidic device includes a micro-fluidic channel having an inner surface and a plurality of pillars positioned along the inner surface. The device further includes a plurality of power supplies connected to the pillars. Another example micro-fluidic device includes a micro-fluidic channel having an inner surface and a plurality of pillars positioned along the inner surface. The device further includes a power supply. The pillars are grouped into at least two groups of pillars, each group of pillars including at least two pillars, and all pillars of at least one group of pillars are connected to the power supply. In another example, a sensing system for detecting bioparticles includes a micro-fluidic device, wherein a surface of each pillar comprises functionalized plasmonic nanoparticles or functionalized SERS nanoparticles, a radiation source for radiating the micro-fluidic device, and a detector for detecting SERS signals or surface plasmon resonance.Type: GrantFiled: May 17, 2014Date of Patent: December 5, 2017Assignee: IMECInventors: Chengjun Huang, Chengxun Liu, Liesbet Lagae, Paolo Fiorini, Benjamin Jones
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Publication number: 20170205330Abstract: A particle screening device is provided. The particle screening device comprises: a substrate including a first side and a second side opposite to the first side; a micropore array formed on the substrate, wherein each micropore penetrates through the substrate from the first side to the second side and has a size configured to at least permit particles smaller than target particles flow through; and electrodes formed on at least one side of the first and second sides of the substrate and around at least some micropores, wherein the electrodes are configured to generate an electric field at corresponding micropores.Type: ApplicationFiled: June 24, 2015Publication date: July 20, 2017Applicant: Ocular Fluidics, Inc.Inventors: Chengjun Huang, Jun Luo, Chao Zhao
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Patent number: 9683253Abstract: The present invention provides a method to analyze or identify a cell. The method comprises: providing a cell, stimulating the cell with a stimulant thereby modifying a cell membrane impedance of the cell, monitoring the cell membrane impedance of the cell and identifying the cell based on the monitored cell membrane impedance. A corresponding device is also provided.Type: GrantFiled: March 19, 2014Date of Patent: June 20, 2017Assignee: IMECInventors: Chengxun Liu, Willem Van Roy, Liesbet Lagae, Chengjun Huang
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Patent number: 9678014Abstract: In a first aspect, a micro-fluidic device is presented, comprising: a micro-fluidic channel having an inner surface; a sensing region inside the micro-fluidic channel configured for adsorbing at least one analyte, the sensing region comprising a plurality of pillars positioned along the length of the inner surface of the micro-fluidic channel wherein the plurality of pillars are configured for creating an electromagnetic field localization thereby making the sensing region suitable for sensing plasmonic or surface enhanced Raman signals when irradiated; characterized in that: the plurality of pillars are further configured for creating a capillary action in the micro-fluidic channel when a fluid sample is present in the micro-fluidic channel.Type: GrantFiled: November 26, 2014Date of Patent: June 13, 2017Assignee: IMEC VZWInventors: Chengjun Huang, Liesbet Lagae
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Publication number: 20160370279Abstract: A microfluidic magnetic selector comprises a microfluidic channel comprising at least one bifurcation, forming a selection portion of the selector and splitting the microfluidic channel into a main channel and at least one selection channel; at least one magnetic flux concentrator for concentrating a magnetic flux at the level of the bifurcation, and means for generating a magnetic field within the magnetic flux concentrator, and a controller for controlling magnetic pulses through the magnetic flux concentrator.Type: ApplicationFiled: June 10, 2016Publication date: December 22, 2016Inventors: Richard Min, Liesbet Lagae, Chengxun Liu, Chengjun Huang
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Patent number: 9522934Abstract: Provided are acetaic abiraterone trifluoroacetate, a preparation method and an application of same. The acetaic abiraterone trifluoroacetate is obtained through a salt-forming reaction between acetaic Abiraterone and trifluoroacetic acid. The acetaic abiraterone trifluoroacetate undergoes self-purification through recrystallization, and dissociation and recrystallization are performed on the purified abiraterone acetate trifluoroacetate, so that the obtained acetaic abiraterone has a high purity, a high yield and stable quality, and is capable of meeting the requirement for mass production of acetaic abiraterone.Type: GrantFiled: February 20, 2013Date of Patent: December 20, 2016Assignees: Shanghai Cdymax Pharmaceuticals Co., Ltd., Jiangsu Cdymax Pharmaceuticals Co., Ltd., Shanghai Acebright Pharmaceuticals Group Co., Ltd.Inventors: Xiaoxia An, Chengjun Huang, Fengwang Mao
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Publication number: 20150153283Abstract: In a first aspect, a micro-fluidic device is presented, comprising: a micro-fluidic channel having an inner surface; a sensing region inside the micro-fluidic channel configured for adsorbing at least one analyte, the sensing region comprising a plurality of pillars positioned along the length of the inner surface of the micro-fluidic channel wherein the plurality of pillars are configured for creating an electromagnetic field localization thereby making the sensing region suitable for sensing plasmonic or surface enhanced Raman signals when irradiated; characterized in that: the plurality of pillars are further configured for creating a capillary action in the micro-fluidic channel when a fluid sample is present in the micro-fluidic channel.Type: ApplicationFiled: November 26, 2014Publication date: June 4, 2015Applicant: IMEC VZWInventors: Chengjun Huang, Liesbet Lagae
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Publication number: 20150133652Abstract: Provided are acetaic abiraterone trifluoroacetate, a preparation method and an application of same. The acetaic abiraterone trifluoroacetate is obtained through a salt-forming reaction between acetaic Abiraterone and trifluoroacetic acid. The acetaic abiraterone trifluoroacetate undergoes self-purification through recrystallization, and dissociation and recrystallization are performed on the purified abiraterone acetate trifluoroacetate, so that the obtained acetaic abiraterone has a high purity, a high yield and stable quality, and is capable of meeting the requirement for mass production of acetaic abiraterone.Type: ApplicationFiled: February 20, 2013Publication date: May 14, 2015Inventors: Xiaoxia An, Chengjun Huang, Fengwang Mao
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Publication number: 20140339090Abstract: An example micro-fluidic device includes a micro-fluidic channel having an inner surface and a plurality of pillars positioned along the inner surface. The device further includes a plurality of power supplies connected to the pillars. Another example micro-fluidic device includes a micro-fluidic channel having an inner surface and a plurality of pillars positioned along the inner surface. The device further includes a power supply. The pillars are grouped into at least two groups of pillars, each group of pillars including at least two pillars, and all pillars of at least one group of pillars are connected to the power supply. In another example, a sensing system for detecting bioparticles includes a micro-fluidic device, wherein a surface of each pillar comprises functionalized plasmonic nanoparticles or functionalized SERS nanoparticles, a radiation source for radiating the micro-fluidic device, and a detector for detecting SERS signals or surface plasmon resonance.Type: ApplicationFiled: May 17, 2014Publication date: November 20, 2014Applicant: IMECInventors: Chengjun Huang, Chengxun Liu, Liesbet Lagae, Paolo Fiorini, Benjamin Jones