Patents by Inventor Chengru Zhu

Chengru Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Live attenuated bacterial vaccine to reduce or inhibit carriage and shedding of enterohemorrhagic in cattle
    Patent number: 8858930
    Abstract: The invention provides live, attenuated enterohemorrhagic Escherichia coli (EHEC) bacteria in which the Shiga toxin coding sequences are deleted to abolish Shiga toxin production and one or more of the nucleotide sequences for the bacterial adhesin protein intimin, the locus of enterocyte effacement encoded regulator, and the translocated intimin receptor are mutated to inactivate the activity of the encoded protein(s). This live, attenuated E. coli bacteria is used in a vaccine for reducing or inhibiting carriage and shedding of EHEC in cattle.
    Type: Grant
    Filed: October 26, 2005
    Date of Patent: October 14, 2014
    Assignees: The United States of America as Represented by the Department of Veteran Affairs
    Inventors: Chengru Zhu, Edgar Boedeker
  • Live Attenuated Bacterial Vaccine to Reduce or Inhibit Carriage and Shedding of Enterohemorrhagic Escherichia Coli in Cattle
    Publication number: 20080286310
    Abstract: The invention provides live, attenuated enterohemorrhagic Escherichia coli (EHEC) bacteria in which the Shiga toxin coding sequences are deleted to abolish Shiga toxin production and one or more of the nucleotide sequences for the bacterial adhesin protein intimin, the locus of enterocyte effacement encoded regulator, and the translocated intimin receptor are mutated to inactivate the activity of the encoded protein(s). This live, attenuated E. coli bacteria is used in a vaccine for reducing or inhibiting carriage and shedding of EHEC in cattle.
    Type: Application
    Filed: October 26, 2005
    Publication date: November 20, 2008
    Applicant: UNIVERSITY OF MARYLAND BALTIMORE
    Inventors: Chengru Zhu, Edgar Boedeker