Patents by Inventor Chengsen ZHANG

Chengsen ZHANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cartridges, systems and methods for mass spectrometry
    Patent number: 11998907
    Abstract: The present disclosure provides “all-in-one” cartridges which contain necessary reagents and materials to isolate/preconcentrate targeted proteins from blood plasma and ionize them for mass spectrometry detection. In another configuration, the cartridges include proteolytic enzymes to digest the proteins into smaller peptides in addition to preconcentration and ionization for mass spectrometry detection.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: June 4, 2024
    Assignee: The Trustees of Indiana University
    Inventors: Nicholas Edward Manicke, Chengsen Zhang
  • Cartridges, systems, and methods for mass spectrometry
    Patent number: 11581175
    Abstract: Mass spectrometry cartridge including a base in mechanical communication with a spray substrate holder, an absorbent pad between the base and the spray substrate holder, a translatable sample well holder interposed between the spray substrate holder and a top cover, the top cover configured to house a conductive element, wherein when the translatable sample well holder is in a first position, the translatable well holder is vertically above the absorbent pad, when the translatable sample well holder is in a second position, the translatable well holder is vertically above a spray substrate are disclosed. Methods of analyzing a sample are also disclosed.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: February 14, 2023
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Nicholas Manicke, Chengsen Zhang
  • CARTRIDGES, SYSTEMS AND METHODS FOR MASS SPECTROMETRY
    Publication number: 20210387175
    Abstract: The present disclosure provides “all-in-one” cartridges which contain necessary reagents and materials to isolate/preconcentrate targeted proteins from blood plasma and ionize them for mass spectrometry detection. In another configuration, the cartridges include proteolytic enzymes to digest the proteins into smaller peptides in addition to preconcentration and ionization for mass spectrometry detection.
    Type: Application
    Filed: April 11, 2019
    Publication date: December 16, 2021
    Applicant: The Trustees of Indiana University
    Inventors: Nicholas Edward Manicke, Chengsen Zhang
  • CARTRIDGES, SYSTEMS, AND METHODS FOR MASS SPECTROMETRY
    Publication number: 20210296106
    Abstract: Mass spectrometry cartridge including a base in mechanical communication with a spray substrate holder, an absorbent pad between the base and the spray substrate holder, a translatable sample well holder interposed between the spray substrate holder and a top cover, the top cover configured to house a conductive element, wherein when the translatable sample well holder is in a first position, the translatable well holder is vertically above the absorbent pad, when the translatable sample well holder is in a second position, the translatable well holder is vertically above a spray substrate are disclosed. Methods of analyzing a sample are also disclosed.
    Type: Application
    Filed: September 19, 2017
    Publication date: September 23, 2021
    Applicant: Indiana University Research and Technology Corporation
    Inventors: Nicholas Manicke, Chengsen Zhang
  • Device and method for analysis of biofluids by ion generation using wetted porous material
    Patent number: 10483096
    Abstract: The present disclosure provides a mass spectrometry cartridge and methods of use thereof.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: November 19, 2019
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Nicholas Manicke, Chengsen Zhang
  • DEVICE AND METHOD FOR ANALYSIS OF BIOFLUIDS BY ION GENERATION USING WETTED POROUS MATERIAL
    Publication number: 20180033600
    Abstract: The present disclosure provides a mass spectrometry cartridge and methods of use thereof.
    Type: Application
    Filed: February 10, 2016
    Publication date: February 1, 2018
    Applicant: Indiana University Research and Technology Corporation
    Inventors: Nicholas MANICKE, Chengsen ZHANG