Abstract: A high aspect ratio in-plane metal microneedle array, a manufacturing method and a clamping and inserting auxiliary device thereof is disclosed. A large-size metal sheet is cut into small metal sheets. A clamping tooling composed of two upper and lower metal cover plates is processed. Inner sides of the upper and the lower cover plates of the tooling are provided with grooves in which the metal sheets are placed and fastened by bolts. Wire cutting is conducted on the tooling and the metal sheets as a whole to obtain a plane metal microneedle array with a plurality of microneedle bodies. In addition, an assembling and clamping device and an inserting auxiliary device of the high aspect ratio in-plane metal microneedle array is provided. The assembled inserting auxiliary device is placed on skin, and the microneedle array is inserted into the skin through the auxiliary device.

Abstract: Provided are bivalent compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the bivalent compounds, and methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof, and methods for identifying such bivalent compounds.

Abstract: A rapid sintering system and rapid sintering method, the rapid sintering system comprising: a furnace body (110) comprising a hearth (111) and a furnace mouth (112) that communicate with each other; a lifting device (120) arranged below the furnace mouth (112), comprising a support (122) and a sample stage (121), the sample stage (121) being disposed on the support (122); a temperature acquisition device (130), disposed on the sample stage (121); a control device (140), disposed outside of the hearth (111), electrically connected to the lifting device (120) and the temperature acquisition device (130) and used to control lifting of the lifting device (120) according to a temperature acquired by the temperature acquisition device (130) and a preset sintering condition; and a spacer (150), disposed at a first end of the lifting device (120), a first spacing being present between the spacer (150) and the sample stage (121), and the furnace mouth (112) is blocked by the spacer (150) when the rapid sintering syste

Abstract: Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.

Abstract: A pre-sintered porcelain block for dental restoration; the pre-sintered porcelain block does not contain crystal phases and has a Vickers hardness of 0.5-2 GPa. Due to a hardness which is significantly lower than that of the porcelain block containing a lithium metasilicate crystal phase, the pre-sintered porcelain block may be processed by using dry machining and can simultaneously be processed by using wet machining when being mechanically processed into a dental restoration shape.

Abstract: Disclosed is a pre-sintered ceramic block for a dental restoration, which has a low pre-sintering temperature, contains a silica main crystal phase, but does not contain or contains a small amount of lithium metasilicate crystal phase. The pre-sintered ceramic block has a low hardness, with a Vickers hardness of 0.5-3 GPa, which is significantly lower than that of a ceramic block containing a lithium metasilicate crystal phase, and same is suitable for dry machining and also wet machining when being machined into a dental restoration. (FIG.

Abstract: Disclosed is a sintering furnace comprising a furnace body and a lifting device, wherein the furnace body comprises a furnace chamber (10) and a furnace mouth (20), the furnace chamber (10) is connected with the furnace mouth (20), wherein the sintering furnace further comprises a sealing member (30) provided at the lifting device; when the sintering furnace is in a loading or unloading condition, the sealing member (30) blocks the furnace mouth (20). When the sintering furnace is in an unloading condition, the sealing member (30) can block the furnace mouth (20), the furnace chamber (10) does not contact with the outside directly, thus the temperature in the furnace chamber (10) will not drop sharply, and the service life of the sintering furnace will be increased.

Abstract: A rapid sintering system and rapid sintering method, the rapid sintering system comprising: a furnace body (110) comprising a hearth (111) and a furnace mouth (112) that communicate with each other; a lifting device (120) arranged below the furnace mouth (112), comprising a support (122) and a sample stage (121), the sample stage (121) being disposed on the support (122); a temperature acquisition device (130), disposed on the sample stage (121); a control device (140), disposed outside of the hearth (111), electrically connected to the lifting device (120) and the temperature acquisition device (130) and used to control lifting of the lifting device (120) according to a temperature acquired by the temperature acquisition device (130) and a preset sintering condition; and a spacer (150), disposed at a first end of the lifting device (120), a first spacing being present between the spacer (150) and the sample stage (121), and the furnace mouth (112) is blocked by the spacer (150) when the rapid sintering syste

Abstract: Disclosed is a sintering furnace comprising a furnace body and a lifting device, wherein the furnace body comprises a furnace chamber (10) and a furnace mouth (20), the furnace chamber (10) is connected with the furnace mouth (20), wherein the sintering furnace further comprises a sealing member (30) provided at the lifting device; when the sintering furnace is in a loading or unloading condition, the sealing member (30) blocks the furnace mouth (20). When the sintering furnace is in an unloading condition, the sealing member (30) can block the furnace mouth (20), the furnace chamber (10) does not contact with the outside directly, thus the temperature in the furnace chamber (10) will not drop sharply, and the service life of the sintering furnace will be increased.

Abstract: A test bed for electric wheel comprehensive performance is characterized in that the test bed comprises a foundation, a portal frame set on the foundation and including a cross beam and two columns supporting both ends of the cross beam individually, a main pin arm movably connected to the portal frame, and a main rotation shaft revolvably and perpendicularly mounted on the top of the main pin arm, wherein the electric wheel is mounted on the main pin arm and is located inside of the portal frame and right below the main rotation shaft. The test bed further comprises at least one of a road simulation mechanism, an inertia simulation mechanism, a driving power mechanism, a perpendicular loading mechanism, and a steering mechanism which take the simulation test on the electric wheel.

Abstract: A test bed for electric wheel comprehensive performance is characterized in that the test bed comprises a foundation, a portal frame set on the foundation and including a cross beam and two columns supporting both ends of the cross beam individually, a main pin arm movably connected to the portal frame, and a main rotation shaft revolvably and perpendicularly mounted on the top of the main pin arm, wherein the electric wheel is mounted on the main pin arm and is located inside of the portal frame and right below the main rotation shaft. The test bed further comprises at least one of a road simulation mechanism, an inertia simulation mechanism, a driving power mechanism, a perpendicular loading mechanism, and a steering mechanism which take the simulation test on the electric wheel.