Abstract: A high aspect ratio in-plane metal microneedle array, a manufacturing method and a clamping and inserting auxiliary device thereof is disclosed. A large-size metal sheet is cut into small metal sheets. A clamping tooling composed of two upper and lower metal cover plates is processed. Inner sides of the upper and the lower cover plates of the tooling are provided with grooves in which the metal sheets are placed and fastened by bolts. Wire cutting is conducted on the tooling and the metal sheets as a whole to obtain a plane metal microneedle array with a plurality of microneedle bodies. In addition, an assembling and clamping device and an inserting auxiliary device of the high aspect ratio in-plane metal microneedle array is provided. The assembled inserting auxiliary device is placed on skin, and the microneedle array is inserted into the skin through the auxiliary device.

Abstract: A display panel includes: a liquid crystal cell; an optical layer configured to transmit part of light incident onto the optical layer whose polarization direction is parallel to a transmission axis of the optical layer, and reflect a remaining part of the light incident onto the optical layer; a first polarization structure configured to transmit part of light incident onto the first polarization structure whose polarization direction is parallel to a transmission axis of the first polarization structure, and absorb a remaining part of the light incident onto the first polarization structure; and a second polarization structure configured to transmit part of light incident onto the second polarization structure whose polarization direction is parallel to a transmission axis of the second polarization structure, and absorb a remaining part of the light incident onto the second polarization structure.

Abstract: Provided are bivalent compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the bivalent compounds, and methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof, and methods for identifying such bivalent compounds.

Abstract: Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.

Abstract: This disclosure relates to heterobifunctional compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the heterobifunctional compounds, and to methods of use the heterobifunctional compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such heterobifunctional compounds.

Abstract: This disclosure relates to GSPT1 degrader compounds (e.g. small molecule compounds), compositions comprising one or more of the compounds, and to methods of use the compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such compounds.

Abstract: This disclosure relates to bivalent compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the bivalent compounds, and to methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such bivalent compounds.

Abstract: Disclosed are compounds that are chemical inhibitors of SOX11. The compounds disclosed are useful in treatment of various cancers.

Abstract: Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.

Abstract: A data processing method related to the field of artificial intelligence includes adding an architecture parameter to each feature interaction item in a first model, to obtain a second model, where the first model is a factorization machine (FM)-based model, and the architecture parameter represents importance of a corresponding feature interaction item; performing optimization on architecture parameters in the second model to obtain the optimized architecture parameters; and obtaining, based on the optimized architecture parameters and the first model or the second model, a third model through feature interaction item deletion.

Abstract: The present disclosure provides a detection system, comprising a client for unloading malicious HTTP traffic and a server for receiving and detecting the malicious HTTP traffic, wherein the server comprises an active label corrector for correcting noisy labels of the malicious HTTP traffic and a multi-field feature extractor for automatically discovering underlying features of the malicious HTTP traffic.

Abstract: Heterobifunctional small molecules including anaplastic lymphoma kinase (ALK) ligand conjugated to a degradation/disruption tag through a linker, which selectively degrade/disrupt ALK, ALK fusion proteins, and/or ALK mutant proteins, and compositions and methods of using such degraders/disruptors to treat ALK-mediated cancer are provided.

Abstract: The present disclosure provides a detection system, comprising a client for unloading malicious HTTP traffic and a server for receiving and detecting the malicious HTTP traffic, wherein the server comprises an active label corrector for correcting noisy labels of the malicious HTTP traffic and a multi-field feature extractor for automatically discovering underlying features of the malicious HTTP traffic.

Abstract: A de-duplication-based remote replication method and an apparatus are provided in a system including a primary end device and a disaster recovery end device, and both the primary end device and the disaster recovery end device store a first snapshot; the primary end device obtains a second snapshot of the primary end device, and sends the first data block, the fingerprint of the first data block, and metadata of the added data blocks to the disaster recovery end device when a fingerprint of a first data block in the added data blocks is different from the fingerprints of the data blocks in the first snapshot.

Abstract: The present disclosure provides compounds that may be useful for inhibiting Wnt pathway comprising compounds of the formula: (Ia) or (Ib) wherein the variables are as defined herein. In some aspects, the compounds may be used to inhibit the Wnt pathway and used to treat cancer, myocardial infarction, osteopetrosis, or used in the maturation of a precursor cell to a mature cell. Also provided herein in are pharmaceutical compositions of the compounds described herein.

Abstract: A method and a system for acquiring a rotor position of a rotary transformer are provided. The system includes: a rotary transformer decoder, a low pass filter and a microprocessor, which includes a synchronous demodulation module and a calculation module. The rotary transformer decoder outputs an excitation signal and acquires first position information of the motor rotor. The calculation module performs calculation to acquire second position information of the motor rotor. The rotary transformer decoder and software decoding are integrated to acquire two rotor positions, and the two rotor positions are compared. In a case that a preset determining condition is met, one of the rotor positions is used for motor control, and the other is used as redundant data for backup, thereby improving the reliability of the acquired rotor position.

Abstract: The present disclosure directs to solutions for performing deduplication by a storage device. In the solutions, according to a duplicate data locality principle, non-duplicate data blocks whose logical addresses are contiguous are stored in contiguous physical addresses in a sequence of the logical addresses, and fingerprints of the non-duplicate data blocks whose logical addresses are contiguous are also stored in contiguous physical addresses in the sequence of the logical addresses, and in addition, a mapping from a logical address, which is of one data block in the non-duplicate data blocks whose logical addresses are contiguous, to an aggregation address is established.

Abstract: Embodiments of the present disclosure disclose a solution for data backup and recovery in a storage system. When a source device in the storage system backs up, to a backup-end device, a data block that is written after a snapshot Sn, the source device performs a logical operation such as an exclusive-NOR or exclusive-OR operation on the written data block and an original data block, which is recorded in the snapshot Sn, of the written data block, and then compresses a data block obtained after the logical operation, which improves a compression ratio of a data block, thereby reducing an amount of data that is sent to the backup-end device, and saving transmission bandwidth. The solution may be further applied to a scenario of data recovery in a storage system.

Abstract: Embodiments of the present invention provide a method for searching for a data stream dividing point based on a server. In the embodiments of the present invention, a data stream dividing point is searched for by determining whether at least a part of data in a window of M windows meets a preset condition, and when the at least a part of data in the window does not meet the preset condition, a length of N*U is skipped, so as to obtain a next potential dividing point, thereby improving efficiency of searching for a data stream dividing point.

Abstract: A method and a system for acquiring a rotor position of a rotary transformer are provided. The system includes: a rotary transformer decoder, a low pass filter and a microprocessor, which includes a synchronous demodulation module and a calculation module. The rotary transformer decoder outputs an excitation signal and acquires first position information of the motor rotor. The calculation module performs calculation to acquire second position information of the motor rotor. The rotary transformer decoder and software decoding are integrated to acquire two rotor positions, and the two rotor positions are compared. In a case that a preset determining condition is met, one of the rotor positions is used for motor control, and the other is used as redundant data for backup, thereby improving the reliability of the acquired rotor position.