Abstract: Disclosed herein are diamino lipid (dal) compounds and pharmaceutical compositions including mRNA encoding an immunotherapeutic agent and methods of making and use thereof. Also disclosed herein are diamino lipid (DAL) nanoparticles. These nanoparticles can encapsulate a nucleic acid, such as an mRNA, for example. This mRNA can encode a cytokine, such as IL-12, IL-27 and GM-CSF. Also disclosed are methods of treating a subject in need thereof, such as a subject with cancer.

Abstract: A battery module includes multiple cells and a bracket. The multiple cells are stacked along a first direction. Each cell includes a first terminal and a second terminal. The bracket includes multiple groups of through-holes. Each group of through-holes includes a first terminal through-hole and a second terminal through-hole. The first terminal and the second terminal of a same cell pass through the first terminal through-hole and the second terminal through-hole in a same group of through-holes. The multiple groups of through-holes include a first group of through-holes, a second group of through-holes, and third groups of through-holes. Along the first direction, a distance D1 between the first terminal through-hole in the first group of through-holes and the second terminal through-hole in a third group of through-holes adjacent to the first group of through-holes is greater than a distance D3 between two adjacent third groups of through-holes.

Abstract: It is described an orbital incubator shaker, which comprises an incubator housing (1) defining an incubation chamber (2), and an orbital shaker (3) configured to shake a shaking table (4). The orbital shaker (3) comprises a drive motor comprising a stator and a rotor (9), and an eccentric bearing mounted to the rotor (9). The orbital shaker (3) is fixed within the incubation chamber (2) or in a mobile version without fixing just being placed inside the incubation chamber (2). The orbital shaker (3) further comprises a bearing (16) configured to support the rotor (9) on a support structure. The rotor (9), the bearing (16) and the support structure are configured to seal the stator from the incubation chamber (2).

Abstract: A flexible circuit board of a hearing aid and the hearing aid are provided. The flexible circuit board has an annular portion bent into an annular shape, wherein the annular portion is used for surrounding a peripheral side of a battery, and an outer side surface of the annular portion has pads; the flexible circuit board has a device portion located on a front side of the annular portion, wherein the device portion is used for installing electronic devices and is used for electrically connecting a receiver; the flexible circuit board has a chip portion connected to a bottom end of the annular portion, wherein the chip portion is used for binding a chip. The flexible circuit board strings together the receiver, the chip and the battery into a compact structure.

Abstract: A completely-in-canal hearing aid, including a housing, a receiver, a chip, a battery, a flexible circuit board and a microphone, wherein the housing includes a front section and a rear section; the receiver and the chip are located in the front section; the battery is located in the rear section; the rear section has two opposite surfaces and two opposite side surfaces; the front section has a first central axis parallel to the length of the front section; the rear section has a second central axis located between the two opposite surfaces and between the two opposite side surfaces; the first central axis and the second central axis are different straight lines. The completely-in-canal hearing aid is fine and compact in structure, reasonable and ingenious in design, diversified in function and comfortable to wear.

Abstract: A hearing aid electrical contact structure and a hearing aid are provided. The hearing aid electrical contact structure includes: a housing, wherein the housing includes a front section and a rear section connected to each other; the rear section is used for accommodating a battery and at least a part of a flexible circuit board; an outer side surface of the rear section has at least two side holes; a conductive contact sheet is assembled in each of the at least two side holes, and the conductive contact sheet is electrically connected to a pad of the flexible circuit board; an outer surface of the conductive contact sheet realizes a transition with the outer side surface of the rear section. The hearing aid electrical contact structure has a smooth surface without any groove structure or convex structure.

Abstract: A completely-in-canal hearing aid, including a housing, a receiver, a chip, a battery, a flexible circuit board and a microphone, wherein the housing includes a front section and a rear section; the receiver and the chip are located in the front section; the battery is located in the rear section; the rear section has two opposite surfaces and two opposite side surfaces; the front section has a first central axis parallel to the length of the front section; the rear section has a second central axis located between the two opposite surfaces and between the two opposite side surfaces; the first central axis and the second central axis are different straight lines. The completely-in-canal hearing aid is fine and compact in structure, reasonable and ingenious in design, diversified in function and comfortable to wear.

Abstract: A flexible circuit board of a hearing aid and the hearing aid are provided. The flexible circuit board has an annular portion bent into an annular shape, wherein the annular portion is used for surrounding a peripheral side of a battery, and an outer side surface of the annular portion has pads; the flexible circuit board has a device portion located on a front side of the annular portion, wherein the device portion is used for installing electronic devices and is used for electrically connecting a receiver; the flexible circuit board has a chip portion connected to a bottom end of the annular portion, wherein the chip portion is used for binding a chip. The flexible circuit board strings together the receiver, the chip and the battery into a compact structure.

Abstract: A hearing aid electrical contact structure and a hearing aid are provided. The hearing aid electrical contact structure includes: a housing, wherein the housing includes a front section and a rear section connected to each other; the rear section is used for accommodating a battery and at least a part of a flexible circuit board; an outer side surface of the rear section has at least two side holes; a conductive contact sheet is assembled in each of the at least two side holes, and the conductive contact sheet is electrically connected to a pad of the flexible circuit board; an outer surface of the conductive contact sheet realizes a transition with the outer side surface of the rear section. The hearing aid electrical contact structure has a smooth surface without any groove structure or convex structure.

Abstract: A hearing aid microphone structure and a hearing aid are provided. The hearing aid microphone structure includes a microphone, a sound-guiding foam and a dust-proof net. The microphone is arranged on a front surface of a first end plate in a housing, wherein the first end plate is a part of a flexible circuit board, and the first end plate has a sound transmission hole. The sound-guiding foam arranged on a rear surface of the first end plate, wherein the sound-guiding foam has a sound-guiding hole, and the sound-guiding hole is communicated with the sound transmission hole. The dust-proof net arranged on the sound-guiding foam, wherein the dust-proof net has a peripheral portion and a net portion, and the net portion is blocked in front of the sound-guiding hole.

Abstract: The present disclosure relates to compositions and methods for regulating the immune system and for treating cancers and other immune disorders.

Abstract: It is described an orbital incubator shaker, which comprises an incubator housing (1) defining an incubation chamber (2), and an orbital shaker (3) configured to shake a shaking table (4). The orbital shaker (3) comprises a drive motor comprising a stator and a rotor (9), and an eccentric bearing mounted to the rotor (9). The orbital shaker (3) is fixed within the incubation chamber (2) or in a mobile version without fixing just being placed inside the incubation chamber (2). The orbital shaker (3) further comprises a bearing (16) configured to support the rotor (9) on a support structure. The rotor (9), the bearing (16) and the support structure are configured to seal the stator from the incubation chamber (2).

Abstract: The present disclosure discloses an incubator, comprising: a housing defining an incubation chamber, and the incubation chamber is a sealable structure; a shaker located inside the incubation chamber; one or more vent panels, which are each provided with a plurality of vent openings, wherein the incubation chamber is divided into a first area and a second area by the vent panels and the housing, and the shaker is located inside the first area; and a blowing device, for guiding gas flow; wherein, gas in the incubation chamber is driven to circulate between the first area and the second area through cooperation of the vent panels, an inner wall of the housing and the blowing device.

Abstract: The present disclosure provides a hearing aid charger case. The hearing aid charger case comprises a housing, a lining and a charger module. The housing comprises a lid body and a lower housing; the lid body and the lower housing body are pivoted to each other through a hinge; a back surface of the lower housing body is disposed with a USB interface that connects a power supply. The lining and the charger module are arranged in the lower housing body, and the lining is located above the charger module and is fixedly connected to the charger module, and the inside of the lining are provided with two charging bays. The bottom of each charging bay is disposed with two charging pins at intervals. The hearing aid charger case can charge and store two hearing aids at the same time, which is greatly convenient for the users.