Publication number: 20250044304
Abstract: The present application relates to an antibody, kit, detection method, and sample analyzer for detecting thyroid stimulating hormone. Specifically, the present application relates to a monoclonal antibody or antigen-binding antibody fragment thereof that specifically binds to thyroid stimulating hormone (TSH), wherein the antibody can recognize TSH variant R55G and does not cross-react with an ?-subunit shared by human luteinizing hormone (LH), follicle stimulating hormone (FSH), human chorionic gonadotropin (hCG), and free glycoprotein hormones, and is particularly suitable for developing TSH detection kit with a functional sensitivity of ?0.0015 ?IU/ml. The present application also relates to a thyroid stimulating hormone detection kit, detection method, and sample analyzer.
Type:
Application
Filed:
July 25, 2024
Publication date:
February 6, 2025
Applicants:
SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD., HyTest Ltd.
Inventors:
Karina R. Seferian, Evgenia O. Kuzichkina, Erzhena G. Altaeva, Fedor N. Rozov, Stanislav V. Kozlovsky, Yury N. Lezhnin, Kristina M. Gaynova, Liudmila V. Ageeva, Natalia A. Gruzdeva, Natalia N. Tamm, Elizaveta D. Kulieva, Anna A. Trufanova, Sergei A. Kotlov, Chengxiong ZHAN, Qixue SONG, Tao TANG, Yufeng YAN, Ke LI
Publication number: 20250034236
Abstract: This application provides an antibody or antigen-binding fragment thereof that binds to thyroglobulin, including: a heavy chain variable region having: CDR-H1 having an amino acid sequence selected from SEQ ID NOs: 1, 7, 13, 19, 25, 31, and variants thereof, CDR-1-12 having an amino acid sequence selected from SEQ ID NOs: 2, 8, 14, 20, 26, 32, and variants thereof, and CDR-H3 having an amino acid sequence selected from SEQ ID NOs: 3, 9, 15, 21, 27, 33, and variants thereof; and a light chain variable region having: CDR-L1 having an amino acid sequence selected from SEQ ID NOs: 4, 10, 16, 22, 28, 34, and variants thereof, CDR-L2 having an amino acid sequence selected from SEQ ID NOs: 5, 11, 17, 23, 29, 35, and variants thereof, and CDR-L3 having an amino acid sequence selected from SEQ ID NOs: 6, 12, 18, 24, 30, 36, and variants thereof.
Type:
Application
Filed:
July 25, 2024
Publication date:
January 30, 2025
Applicants:
SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD., HyTest Ltd.
Inventors:
Alexander G. Semenov, Evgeniya E. Feygina, Elizaveta E. Sokolova, Chengxiong ZHAN, Xiaotong LI, Tao TANG, Puguang CHEN, Ke LI