Abstract: Herein disclosed is a method of encapsulating a spheroid in a gel, the method comprising: providing a frame comprising a base and an island protruding from the base; depositing one or more suspensions on the island, wherein the one or more suspensions comprise different cells; arranging the frame to have the one or more suspensions hang from the island in a direction which gravity acts to render growth of the spheroid; depositing a gel on the spheroid with the spheroid resting on the island to have the gel encapsulate the spheroid; and arranging the frame against a substrate with the base distally positioned from the substrate (i) to have the gel confined between the island and the substrate and (ii) to have the gel encapsulate the spheroid.

Abstract: The present invention refers to a composition comprising a viral protein or fragment thereof, wherein the viral protein or fragment thereof is enclosed within a self-assembling protein nanocapsule, preferably ferritin, and wherein the viral protein, or fragment thereof is selected from a virus of the Togaviridae family. The viral protein or fragment thereof may also further be selected from a virus of the alphavirus subfamily.

Abstract: The present invention refers to a composition comprising a viral protein or fragment thereof, wherein the viral protein or fragment thereof is enclosed within a self-assembling protein nanocapsule, preferably ferritin, and wherein the viral protein, or fragment thereof is selected from a virus of the Togaviridae family. The viral protein or fragment thereof may also further be selected from a virus of the alphavirus subfamily.