Patents by Inventor Chengzhang Shang

Chengzhang Shang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-EGFR/MET ANTIBODIES AND USES THEREOF
    Publication number: 20250122292
    Abstract: This disclosure relates to antigen-binding protein constructs (e.g., bispecific antibodies, antigen-binding fragments thereof, or ADCs), wherein the antigen-binding protein constructs specifically bind to two different antigens (e.g., EGFR and MET).
    Type: Application
    Filed: December 20, 2024
    Publication date: April 17, 2025
    Inventors: Yanfei HAN, Chengzhang SHANG, Baihong LIU, Yi YANG, Yuelei SHEN
  • ANTI-HER2/TROP2 ANTIBODIES AND USES THEREOF
    Publication number: 20250059297
    Abstract: Provided are anti-HER2 antibodies or antigen binding fragments thereof, anti-TROP2 antibodies or antigen binding fragments thereof, antigen-binding protein constructs (e.g., bispecific antibodies or antigen-binding fragments thereof) that specifically bind to two different antigens (e.g., HER2 and TROP2), and antibody drug conjugates.
    Type: Application
    Filed: January 19, 2023
    Publication date: February 20, 2025
    Inventors: Chengzhang Shang, Liu Yang, Yanfei Han, Yuelei Shen
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC TFR1
    Publication number: 20240268361
    Abstract: Provided are genetically modified non-human animals that express a human or chimeric (e.g., humanized) TFR1, and methods of use thereof.
    Type: Application
    Filed: July 15, 2022
    Publication date: August 15, 2024
    Inventors: Chang Liu, Chengzhang Shang, Xiaofei Zhou
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC IL1RAP
    Publication number: 20240224961
    Abstract: Provided are genetically modified animal expressing human or chimeric (e.g., humanized) IL1RAP, and methods of use thereof.
    Type: Application
    Filed: May 27, 2022
    Publication date: July 11, 2024
    Inventors: Xiaofei Zhou, Chengzhang Shang, Chonghui Liu
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD3 GENES
    Publication number: 20240130340
    Abstract: Provided are genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD3E (T-cell surface glycoprotein CD3 epsilon chain), CD3D (T-cell surface glycoprotein CD3 delta chain), and/or CD3G (T-cell surface coprotein CD3 gamma chain), and methods of use thereof.
    Type: Application
    Filed: February 18, 2022
    Publication date: April 25, 2024
    Inventors: Chengzhang Shang, Chong Li, Chang Liu
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC FCRN
    Publication number: 20240081301
    Abstract: Provided are genetically modified animal expressing human or chimeric (e.g., humanized) FcRn, and methods of use thereof.
    Type: Application
    Filed: January 29, 2022
    Publication date: March 14, 2024
    Inventors: Chengzhang Shang, Chong Li, Chang Liu, Dirui Li
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC GLP1R
    Publication number: 20230363362
    Abstract: This disclosure relates to genetically modified animal expressing human or chimeric (e.g., humanized) GLP1R, and methods of use thereof.
    Type: Application
    Filed: September 17, 2021
    Publication date: November 16, 2023
    Inventors: Yuelei Shen, Jiawei Yao, Yanan Guo, Yang Bai, Chengzhang Shang
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CCR8
    Publication number: 20230320332
    Abstract: Provided are genetically modified non-human animals that express a human or chimeric (e.g., humanized) CCR8, and methods of use thereof.
    Type: Application
    Filed: September 10, 2021
    Publication date: October 12, 2023
    Inventors: Yuelei SHEN, Yang BAI, Chaoshe GUO, Meiling ZHANG, Rui HUANG, Chengzhang SHANG
  • Genetically modified mice expressing humanized CD47
    Patent number: 11723348
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD47, and methods of use thereof.
    Type: Grant
    Filed: November 2, 2020
    Date of Patent: August 15, 2023
    Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
    Inventors: Yuelei Shen, Yang Bai, Jian Ni, Rui Huang, Chengzhang Shang, Yanan Guo
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL EXPRESSING A B2M/FCRN FUSION PROTEIN
    Publication number: 20230227531
    Abstract: The present disclosure relates to genetically modified non-human animals that express a fusion protein including B2M and FcRn, and methods of use thereof. In some embodiments, the animals can have a B-NDG background. In some embodiments, the endogenous B2M gene is knocked out in the animals.
    Type: Application
    Filed: June 18, 2021
    Publication date: July 20, 2023
    Inventors: Yuelei Shen, Jiawei Yao, Yanan Guo, Yang Bai, Chengzhang Shang
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD94 AND/OR NKG2A
    Publication number: 20230172171
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD94 and/or NKG2A, and methods of use thereof.
    Type: Application
    Filed: May 21, 2021
    Publication date: June 8, 2023
    Inventors: Yuelei Shen, Yang Bai, Chaoshe Guo, Meiling Zhang, Rui Huang, Chengzhang Shang
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC MHC PROTEIN COMPLEX
    Publication number: 20230072216
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) major histocompatibility complex (MHC) protein complex, and methods of use thereof.
    Type: Application
    Filed: January 8, 2021
    Publication date: March 9, 2023
    Inventors: Yuelei Shen, Chaoshe Guo, Meiling Zhang, Rui Huang, Yanan Guo, Yang Bai, Jiawei Yao, Chengzhang Shang
  • GENETICALLY MODIFIED IMMUNODEFICIENT NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPa/CD47
    Publication number: 20230058049
    Abstract: This disclosure relates to genetically modified immunodeficient animals which express a human or chimeric (e.g., humanized) SIRP? and/or human or chimeric (e.g., humanized) CD47, and methods of use thereof.
    Type: Application
    Filed: December 31, 2020
    Publication date: February 23, 2023
    Inventors: Yuelei Shen, Yang Bai, Jiawei Yao, Chaoshe Guo, Meiling Zhang, Rui Huang, Yanan Guo, Chengzhang Shang
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC IL2RA
    Publication number: 20220312749
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL2RA, and methods of use thereof.
    Type: Application
    Filed: August 7, 2020
    Publication date: October 6, 2022
    Inventors: Yuelei Shen, Yang Bai, Chengzhang Shang, Rui Huang, Meiling Zhang, Jiawei Yao, Chaoshe Guo, Yanan Guo
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC IL33
    Publication number: 20220272953
    Abstract: Provided are genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL33, and methods of use thereof.
    Type: Application
    Filed: July 29, 2020
    Publication date: September 1, 2022
    Inventors: Yuelei Shen, Yanan Guo, Yang Bai, Chengzhang Shang, Rui Huang, Meiling Zhang, Jiawei Yao, Chaoshe Guo
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD73
    Publication number: 20220211019
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD73, and methods of use thereof.
    Type: Application
    Filed: November 20, 2019
    Publication date: July 7, 2022
    Inventors: Yuelei Shen, Yanan Guo, Yang Bai, Rui Huang, Chengzhang Shang, Meiling Zhang, Jiawei Yao, Chaoshe Guo
  • Genetically modified non-human animal with human or chimeric CD28
    Patent number: 11350614
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD28, and methods of use thereof.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: June 7, 2022
    Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
    Inventors: Yuelei Shen, Yang Bai, Yanan Guo, Meiling Zhang, Rui Huang, Chengzhang Shang, Jiawei Yao
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC GENES
    Publication number: 20220015343
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL6R and/or IL6, and methods of use thereof.
    Type: Application
    Filed: December 17, 2019
    Publication date: January 20, 2022
    Inventors: Yuelei Shen, Meiling Zhang, Jiawei Yao, Chaoshe Guo, Yanan Guo, Yang Bai, Rui Huang, Lei Zhao, Chengzhang Shang
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC GENES
    Publication number: 20220000086
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL4R and/or IL4, and methods of use thereof.
    Type: Application
    Filed: September 23, 2021
    Publication date: January 6, 2022
    Inventors: Yuelei Shen, Yanan Guo, Yang Bai, Rui Huang, Xiaofei Zhou, Chengzhang Shang, Meiling Zhang, Jiawei Yao, Chaoshe Guo
  • GENETICALLY MODIFIED ANIMAL WITH CANINE OR CHIMERIC PD-1
    Publication number: 20210400933
    Abstract: The present disclosure relates to genetically modified animals that express a canine or chimeric (e.g., caninized) programmed cell death protein 1 (PD-1), and methods of use thereof.
    Type: Application
    Filed: November 19, 2019
    Publication date: December 30, 2021
    Inventors: Yuelei Shen, Yang Bai, Rui Huang, Xiaofei Zhou, Chengzhang Shang, Meiling Zhang, Jiawei Yao, Chaoshe Guo, Yanan Guo