Patents by Inventor Chengzhe Wu

Chengzhe Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Macrocyclic spiroethers as Mcl-1 inhibitors
    Patent number: 11498928
    Abstract: Provided are compounds represented by Formula (I-A) and the pharmaceutically acceptable salts and solvates thereof, wherein R8, R9a, R9b, R9c, R9d, X, Y, Z, Z1, W, and (aa) are as defined as set forth in the specification. Provided are also compounds of Formula (I-A) for use to treat a condition or disorder responsive to Mcl-1 inhibition such as cancer.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: November 15, 2022
    Assignees: ASCENTAGE PHARMA (SUZHOU) CO., LTD., THE REGENTS OF THE UNIVERSITY OF MICHIGAN, ASCENTAGE PHARMA GROUP CORP LIMITED
    Inventors: Jianyong Chen, Yunlong Zhou, Guozhi Tang, Chengzhe Wu, Leilei Zhao, Lingling Jiao, Binghua Sheng, Shaomeng Wang, Chao-Yie Yang, Hao Chen, Wenliang Hu, Yu Jing
  • MACROCYCLIC SPIROETHERS AS MCL-1 INHIBITORS
    Publication number: 20210340158
    Abstract: Provided are compounds represented by Formula (I-A) and the pharmaceutically acceptable salts and solvates thereof, wherein R8, R9a, R9b, R9c, R9d, X, Y, Z, Z1, W, and (aa) are as defined as set forth in the specification. Provided are also compounds of Formula (I-A) for use to treat a condition or disorder responsive to Mcl-1 inhibition such as cancer.
    Type: Application
    Filed: January 17, 2020
    Publication date: November 4, 2021
    Inventors: Jianyong Chen, Yunlong Zhou, Guozhi Tang, Chengzhe Wu, Leilei Zhao, Lingling Jiao, Binghua Sheng, Shaomeng Wang, Chao-Yie Yang, Hao Chen, Wenliang Hu, Yu Jing