Abstract: This application relates to the technical field of natural language processing, and provides a distributed pipeline-parallel LLM fine-tuning method for heterogeneous GPUs. A plurality of LoRA models are fine-tuned simultaneously based on a multi-job fine-tuning system; each LoRA model is partitioned into a plurality of parts distributed on a corresponding number of GPUs, and the GPUs are sorted. A job configuration module generates a plurality of jobs according to a user request, and divides each job into a plurality of training batches; a dynamic job scheduler generates a scheduling scheme based on a training batch sequence of each job and a dynamic scheduling strategy; and the scheduling scheme is sent to a multi-job training module on each corresponding GPU according to a positive sequence of the GPUs, to train all the LoRA models.

Abstract: Disclosed are a biological material for delivering a specific cell-targeted metabolic system, a preparation method therefor, and an application thereof. The biological material delivers the specific metabolic system into a specific cell by membrane fusion on the basis of cell membrane coating, so that the systematic metabolic regulation effect on the specific cell is achieved, and a new thought is provided for the preparation and application of the biological material designed for systematic cell metabolism regulation strategies.

Abstract: Disclosed are a cell membrane-based biological material for cross-species cell component delivery and a preparation method thereof. The biological material is based on cell membrane coating, and a cross-species cell component is delivered into a specific cell in a membrane fusion mode, so that the cross-species component stably plays a specific function, thus providing a new thought and strategy for intracellular delivery of cross-species immunogenic biological materials.

Abstract: Disclosed are a nano-material for generating ATP and NADPH under red light excitation and a preparation method thereof. By I extracting and nanocrystallizing a plant-derived thylakoid, a nano-thylakoid is obtained, and ATP and NADPH are generated, which are respectively used to enhance biological energy metabolism and substance metabolism, maintain cellular homeostasis, and realize a variety of engineering designs, thus providing a new thought for the preparation and application of biological energy and substance metabolism regulation materials.

Abstract: Disclosed are an oxidation-responsive water-soluble cationic pillararene, and a preparation method and application thereof, the oxidation-responsive water-soluble cationic pillararene is a cyclic small-molecule nucleic acid vector, and is obtained by quaternization reaction of 4-methylborate and tertiary amine-modified pillararene. According to the invention, a delivery vector with a high positive charge density is obtained through small molecule synthesis, the delivery vector is capable of being tightly complexed with negatively charged nucleic acid substances to form a nano-composite, and after the nano-composite enters cells, vector positive charges fall off to release the nucleic acid substances in an oxidation environment, and nucleic acid is efficiently translated and expressed. The delivery vector has the characteristics of simplicity and convenience in synthesis, high delivery efficiency and good biological safety, and has a good application prospect.

Abstract: A nano composite material aiming at an acidic sealing zone in osteoclasts and a preparation method thereof are provided. The nano composite material aiming at the acidic sealing zone in the osteoclasts includes a nano material, bone-targeting molecules, and a compound able to react with the acidic sealing zone in the osteoclasts, wherein: after being modified by the bone-targeting molecules, the nano material is loaded with the compound able to react with the acidic sealing zone in the osteoclasts. Through accurate mature osteoclast targeting and chemically regulated biocascade effects, the osteoclasts are inhibited, which provides a new idea and a new tool for drug therapy of abnormal osteoclast activation.