Abstract: A cordycepin-based derived compound with an anti-tumor effect, and a structure of the compound is as shown in formula I; a cordycepin derivative and a pharmaceutical composition thereof provided by the invention have a good anti-tumor proliferation effect; compared with a parent drug, the cordycepin derivative has better affinity to cell membranes, so that a half-life period of in-vivo metabolism of the drug is longer, and in-vivo remaining time of the drug is longer; compared with other nucleoside anti-tumor drugs, the cordycepin derivative and the pharmaceutical composition thereof provided by the invention have wider types and action ranges of tumors, have excellent inhibition effects on a gastric cancer, a pancreatic cancer, a liver cancer, a small cell lung cancer, a colorectal cancer, melanoma, an ovarian cancer and the like, and have lower side effects and better curative effects.

Abstract: Aspects of the disclosure provide methods of modeling wrong-way driving of road users. For instance, log data including an observed trajectory of a first road user may be accessed. A first set of candidate lane segments for wrong-way driving may be identified from map information. A second set of candidate lane segments for not wrong-way driving may be identified from the map information. For each candidate lane segment in the first set and in the second set, a distance cost between the candidate lane segment and the observed trajectory may be determined. A candidate lane segment may be selected from at least one of the first set or the second set based on the determined distance costs. The selected candidate lane segment may be used to train a model to provide a likelihood of a second road user being engaged in wrong-way driving in a lane.

Abstract: Disclosed is a force applying device for orthodontic treatment being elastically expandable and configured to generate a restoring force as an orthodontic force for an orthodontic treatment when compressed. The force applying device comprises a first element and a second element capable of moving relative to each other along a first axis. The force applying device for orthodontic treatment is compressed when the first and second elements move towards each other along the first axis. A first arm extends laterally from a first end of the first element away from the second element. A first connecting part of a first connector is fitted over the first arm. A second connecting part of the first connector is to be fitted over a button fixed on a first jaw to connect the first element to the first jaw. Both the first and the second connecting parts are toroidal in shape.