Patents by Inventor Chenleng Cai

Chenleng Cai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for treating diseases associated with T-box and N-Myc
    Patent number: 7981615
    Abstract: The invention herein provides a mode of treating a disease associated with the regulation of T-Box and N-Myc gene, which includes cancers and heart disease in human and other subjects by identifying and administering a compound which modulates T-Box or N-Myc function. The invention also provides polynucleotides, polypeptides, vectors, cells, tissues and organisms useful in the identification and treatment of metabolic syndrome. A number of desirable cell proliferation and senescence regulating aspects are achieved by various embodiments of the present invention.
    Type: Grant
    Filed: November 2, 2009
    Date of Patent: July 19, 2011
    Assignee: The Regents of the University of California
    Inventors: Sylvia Evans, Ju Chen, Chenleng Cai, Wenlai Zhou, Michael G. Rosenfeld
  • Use of islet 1 as a marker for isolating or generating stem cells
    Patent number: 7745113
    Abstract: The present invention provides in vitro methods of expansion and propagation of undifferentiated progenitor cells and more specifically undifferentiated progenitor cells containing Islet1, a marker apparently unique to proliferating cardiac stem cells. Methods are described for isolation of stem cell populations as well as for provoking expansion and propagation of undifferentiated progenitor cells without differentiation, to provide cardiac repair or improve cardiac function, for example.
    Type: Grant
    Filed: February 2, 2004
    Date of Patent: June 29, 2010
    Assignee: The Regents of the University of California
    Inventors: Sylvia M. Evans, Ju Chen, Chenleng Cai, Alessandra Moretti, Kenneth R. Chien, Karl-Ludwig Laugwitz
  • Compositions and Methods for Treating Diseases Associated with T-Box and N-Myc
    Publication number: 20100047810
    Abstract: The invention herein provides a mode of treating a disease associated with the regulation of T-Box and N-Myc gene, which includes cancers and heart disease in human and other subjects by identifying and administering a compound which modulates T-Box or N-Myc function. The invention also provides polynucleotides, polypeptides, vectors, cells, tissues and organisms useful in the identification and treatment of metabolic syndrome. A number of desirable cell proliferation and senescence regulating aspects are achieved by various embodiments of the present invention.
    Type: Application
    Filed: November 2, 2009
    Publication date: February 25, 2010
    Inventors: Sylvia Evans, Ju Chen, Chenleng Cai, Wenlai Zhou, Michael G. Rosenfeld
  • Compositions and methods for treating diseases associated with T-box and N-Myc
    Patent number: 7625874
    Abstract: The invention herein provides a mode of treating a disease associated with the regulation of T-Box and N-Myc gene which includes cancers and heart disease in human and other subjects by identifying and administering a compound which modulates T-Box or N-Myc function. The invention also provides polynucleotides, polypeptides, vectors, cells, tissues and organisms useful in the identification and treatment of metabolic syndrome. A number of desirable cell proliferation and senescence regulating aspects are achieved by various embodiments of the present invention.
    Type: Grant
    Filed: April 11, 2007
    Date of Patent: December 1, 2009
    Assignee: The Regents of the University of California
    Inventors: Sylvia Evans, Ju Chen, Chenleng Cai, Wenlai Zhou, Michael G Rosenfeld
  • Compositions and methods for treating diseases associated with T-Box and N-Myc
    Publication number: 20070238692
    Abstract: The invention herein provides a mode of treating a disease associated with the regulation of T-Box and N-Myc gene which includes cancers and heart disease in human and other subjects by identifying and administering a compound which modulates T-Box or N-Myc function. The invention also provides polynucleotides, polypeptides, vectors, cells, tissues and organisms useful in the identification and treatment of metabolic syndrome. A number of desirable cell proliferation and senescence regulating aspects are achieved by various embodiments of the present invention.
    Type: Application
    Filed: April 11, 2007
    Publication date: October 11, 2007
    Applicant: The Regents of the University of California
    Inventors: Sylvia Evans, Ju Chen, Chenleng Cai, Wenlai Zhou, Michael G. Rosenfeld
  • Use of islet 1 as a marker for isolating or generating stem cells
    Publication number: 20060246446
    Abstract: The present invention provides in vitro methods of expansion and propagation of undifferentiated progenitor cells and more specifically undifferentiated progenitor cells containing Islet1, a marker apparently unique to proliferating cardiac stem cells. Methods are described for isolation of stem cell populations as well as for provoking expansion and propagation of undifferentiated progenitor cells without differentiation, to provide cardiac repair or improve cardiac function, for example.
    Type: Application
    Filed: February 2, 2004
    Publication date: November 2, 2006
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Sylvia Evans, Ju Chen, Chenleng Cai, Alessandra Moretti, Kenneth Chien, Karl-Ludwig Laugwitz