Abstract: Provided is a composition for promoting hair growth, which comprises a mixture comprising an extract of Polygonum multiflorum Thunb and silver nanoparticles; and Copper Tripeptide-1, wherein the weight/volume ratio of the Copper Tripeptide-1 to the composition for promoting hair growth is from 0.1 mg/mL to 0.2 mg/mL; wherein the mixture comprising the extract of Polygonum multiflorum Thunb and silver nanoparticles comprises the silver nanoparticles, extract of Polygonum multiflorum Thunb, a stabilizer, and a diluent. The present invention further provides a pharmaceutical composition for promoting hair growth comprising the composition and a pharmaceutically acceptable excipient, and a method for promoting hair growth by administering the pharmaceutical composition to a subject. The composition for promoting hair growth of the present invention can increase hair growth and stimulate the growth of new hair follicles.

Abstract: Provided is an isolated nucleic acid molecule comprising a NKp30 transmembrane domain, and a chimeric antigen receptor comprising the same. The isolated nucleic acid molecule comprising a NKp30 transmembrane domain comprises nucleic acid sequences encoding (a) an extracellular antigen binding domain, comprising a heavy chain variable region; (b) a hinge domain; (c) a NKp30 transmembrane domain; and (d) a NKp30 cytoplasmic domain. By introducing nucleic acid sequences of the NKp30 transmembrane domain and the NKp30 cytoplasmic domain in combination with the extracellular antigen binding domain into a T cell, the resulting CAR-T cell is a multi-chain CAR-T cell with a NKp30 receptor complex. Consequently, the resulting CAR-T cell forms stable immune synapses with cancer cells and exhibits excellent cytotoxicity against cancer cells.

Abstract: A water-based adhesive applied to wood and bamboo includes a main agent composed of water-soluble polymer, synthetic rubber latex and natural latex and a curing agent selected from isocyanate or quaternary ammonium salt polymer. Wherein, the weight ratio of the main agent to the curing agent is between 200:1 and 1:1; the water-soluble polymer is polyvinyl alcohol and is about 2-30 weight percent of the total solids of the main agent; the synthetic rubber latex is about 2-60 weight percent of the total solids of the main agent; and the natural latex is about 5-90 weight percent of the total solids of the main agent. The present invention provides a formaldehyde-free adhesive and introduces natural and renewable raw materials to reduce dependence on petrochemical products and improve the sustainability of related industries.

Abstract: Provided is an isolated nucleic acid molecule encoding a chimeric antigen receptor (CAR), in which the CAR includes a single chain antibody or single chain antibody fragment, a costimulatory domain, a primary intracellular signaling domain. The single chain antibody or single chain antibody fragment includes a murine anti-CD19 binding domain, wherein the murine anti-CD19 binding domain includes a heavy chain variable (VH) region comprising a heavy chain complementarity determining region (CDR H1), a CDR H2, and a CDR H3; and a light chain variable (VL) region comprising a light chain complementarity determining region 1 (CDR L1), a CDR L2, and a CDR L3. The costimulatory domain includes 4-1BB, and the primary intracellular signaling domain includes a native intracellular signaling domain of CD3 zeta.

Abstract: Provided is the use of the peptide for the manufacture of a medicament for treating pain, wherein the medicament comprises an effective amount of the peptide and a pharmaceutically acceptable carrier.

Abstract: Provided is a lentivirus packaging system, which comprises: a transfer plasmid comprising a nucleotide sequence of TAR-reserved-chimeric 5? long terminal repeat (LTR); at least one packaging plasmid comprising a nucleotide sequence encoding TAR RNA binding protein, a nucleotide sequence of rev gene, a nucleotide sequence of gag gene, and a nucleotide sequence of pol gene; and an envelope plasmid. Due to the expression of gene of TAR RNA binding protein by the packaging plasmids, the produced lentivirus has higher virus titer and can improve the transduction rate and the gene delivery efficiency during cell transduction. The present invention further provides a method of improving lentivirus production in a host cell, which comprises using the lentivirus packaging system to transfect the host cell. The present invention further provides a cell transduced by the lentivirus and a method of using the cell for treating cancer.

Abstract: The present invention provides a method for producing CAR T-cells enriched with stem cell-like memory T-cells (Tscm), comprised of: (1) providing PBMCs; (2) isolating of T cells from PBMCs using magnetic beads coated with T-cell specific antibodies; (3) positively selecting T cells by culturing them in the form of T cell-magnetic bead complexes; (4) adding CAR-expressing lentivirus to the activated human T cell-magnetic bead complexes, for transduction of human T cells into CAR-T cells on the human T cell-magnetic bead complexes to obtain human CAR-T cell-magnetic bead complexes; (5) obtaining human CAR-T cells by dissociating the human CAR-T cells from the human CAR-T cell-magnetic bead complexes; and (6) further culturing CAR-T cells to obtain CAR-T cells enriched with Tscm. The present invention expands T cells in a short period of time to obtain CAR-T cells enriched with Tscm, which is suitable for CAR-T immunotherapy.

Abstract: Provided is a spinning solution, comprising a cannabidiol powder and an alginate solution. Besides, the present invention further provides an alginate fiber comprising cannabidiol, and the preparation method and the use thereof. The cannabidiol powder in the spinning solution can be evenly dispersed in the alginate solution, so that the spinning solution of the present invention can be applied to wet spinning to form the alginate fiber comprising cannabidiol. The alginate fiber comprising cannabidiol has anti-oxidative, anti-bacterial, antiinflammatory, and anti-allergic abilities.

Abstract: Provided is a lentivirus packaging system, which comprises: a transfer plasmid comprising a nucleotide sequence of TAR-reserved-chimeric 5? long terminal repeat (LTR); at least one packaging plasmid comprising a nucleotide sequence encoding TAR RNA binding protein, a nucleotide sequence of rev gene, a nucleotide sequence of gag gene, and a nucleotide sequence of pol gene; and an envelope plasmid. Due to the expression of gene of TAR RNA binding protein by the packaging plasmids, the produced lentivirus has higher virus titer and can improve the transduction rate and the gene delivery efficiency during cell transduction. The present invention further provides a method of improving lentivirus production in a host cell, which comprises using the lentivirus packaging system to transfect the host cell. The present invention further provides a cell transduced by the lentivirus and a method of using the cell for treating cancer.

Abstract: The present invention relates to a peptide and use thereof in manufacturing a medicament for treating an inflammatory disease, wherein the peptide comprises an amino acid sequence of SEQ ID NO: 1 and the medicament comprises an effective amount of the peptide and a pharmaceutically acceptable carrier. Also provided is the use of the peptide for the manufacture of a medicament for treating pain, wherein the medicament comprises an effective amount of the peptide and a pharmaceutically acceptable carrier.

Abstract: Hepatitis C virus (HCV) infection is a leading cause for liver cirrhosis and hepatocellular carcinoma worldwide2. Current therapeutic regimens are usually poorly tolerated and only effective in a proportion of infected individuals. We discovered a peptide with sequence of DEAQETAVSSHEQD (SEQ ID NO: 1), a fragment of rabbit ?1-antiproteinase F, and its derivatives DEAQETAVSSHEQ (SEQ ID NO: 2) and QETAVSSHEQD (SEQ ID NO: 3), significantly inhibit serum-borne HCV replication in hADSC and human hepatocytes.

Abstract: A non-polyvinylchloride (non-PVC) surface covering is provided. The non-PVC surface covering includes a bottom material layer. A middle layer is disposed on the bottom material layer, wherein the middle layer includes a middle material layer. A transparent abrasion-resistant layer is disposed on the middle layer, wherein the transparent abrasion-resistant layer includes a polyolefin of 40˜94.95 wt %, a polyolefin elastomer (POE) or a polyolefin plastomer (POP) of 5˜50 wt %, and a processing agent of 0.05˜10 wt %.

Abstract: Hepatitis C virus replication at extrahepatic sites has been suggested; however, complete viral replication has only been confirmed in hepatocytes. Here we show that human adipogenic DLK-1+ stem cells (hADSC) freshly isolated from HCV-infected individuals contained viral transcripts, replication intermediates and viral antigens in vivo, and viral transcripts increased in supernatants upon prolonged ex vivo culture. Furthermore, naive hADSC isolated from HCV (?) individuals support complete replication of clinical isolates in vitro, and the infection is donor-nonspecific for cells and cross-genotypic for viruses. Viral infection/replication is mediated through CD81, LDL-R, SR-B1, EGFR, Apolipoprotein E, occludin, claudin-1, NPC1L1 and diacylglycerol acetyltransferase-1, and can be inhibited by anti-viral drugs.

Abstract: The present invention provides a method for treating or ameliorating cerebrovascular diseases in a subject by using peptides isolated from extracts from rabbit skin inflamed by vaccinia virus. The present invention also provides a peptide comprising an amino acid sequence having at least 70% identity to SEQ ID NO: 1, or variants, mutants, derivatives, or fragments thereof.

Abstract: A non-polyvinylchloride (non-PVC) surface covering is provided. The non-PVC surface covering includes a bottom material layer. A middle layer is disposed on the bottom material layer, wherein the middle layer includes a middle material layer. A transparent abrasion-resistant layer is disposed on the middle layer, wherein the transparent abrasion-resistant layer includes a polyolefin of 40˜94.95 wt %, a polyolefin elastomer (POE) or a polyolefin plastomer (POP) of 5˜50 wt %, and a processing agent of 0.05˜10 wt %.

Abstract: The present invention provides a peptide with sequence of DEAQETAVSSHEQD, a fragment of rabbit-?1 antiproteinase F, and its derivatives DEAQETAVSSHEQ and QETACSSHEQD, which significantly inhibit serum-borne HCV replication in hADSC and human hepatocytes.

Abstract: The present invention provides a method for treating or ameliorating cerebrovascular diseases in a subject by using peptides isolated from extracts from rabbit skin inflamed by vaccinia virus. The present invention also provides a peptide comprising an amino acid sequence having at least 70% identity to SEQ ID NO: 1, or variants, mutants, derivatives, or fragments thereof.

Abstract: Hepatitis C virus replication at extrahepatic sites has been suggested; however, complete viral replication has only been confirmed in hepatocytes. Here we show that human adipogenic DLK-1+ stem cells (hADSC) freshly isolated from HCV-infected individuals contained viral transcripts, replication intermediates and viral antigens in vivo, and viral transcripts increased in supernatants upon prolonged ex vivo culture. Furthermore, naive hADSC isolated from HCV (?) individuals support complete replication of clinical isolates in vitro, and the infection is donor-nonspecific for cells and cross-genotypic for viruses. Viral infection/replication is mediated through CD81, LDL-R, SR-B1, EGFR, Apolipoprotein E, occludin, claudin-1, NPC1L1 and diacylglycerol acetyltransferase-1, and can be inhibited by anti-viral drugs.

Abstract: In a non-PVC tile, a bottom material layer, a printing layer and a transparent wear-resistant layer are disposed from bottom to top. The printing layer includes an inorganic filling material of 55˜90 percentage weight (wt %). The coefficient of thermal expansion of the bottom material layer and the transparent wear-resistant layer are larger than that of the printing layer. When the bottom material layer, the printing layer and the transparent wear-resistant layer are heated and then cooled, the bottom material layer and the transparent wear-resistant layer symmetrically contract with the printing layer being a center.

Abstract: In a non-PVC tile, a bottom material layer, a printing layer and a transparent wear-resistant layer are disposed from bottom to top. The printing layer includes an inorganic filling material of 55˜90 percentage weight (wt %). The coefficient of thermal expansion of the bottom material layer and the transparent wear-resistant layer are larger than that of the printing layer. When the bottom material layer, the printing layer and the transparent wear-resistant layer are heated and then cooled, the bottom material layer and the transparent wear-resistant layer symmetrically contract with the printing layer being a center.