Abstract: The invention includes methods for modulating a reaction dependent on a blue light-dependent protein interaction between a CRY protein and a CRY-signaling protein. The method comprises combining a CRY protein and a CRY-signaling protein with a BIC protein, wherein the BIC protein modulates the blue light-dependent interaction between the CRY protein and the CRY-signaling protein. Embodiments of the invention include compositions of matter comprising a CRY gene or protein, a CRY-signaling gene or protein, and a BIC gene or protein (optionally linked to a heterologous nucleic acid or amino acid sequence), wherein the BIC protein modulates a blue light-dependent interaction between the CRY protein and the CRY-signaling protein.

Abstract: The present invention relates to the discovery that the two ACE domains can have very different effects on cytokine expression. In one embodiment, the present invention provides a method of regulating and/or treating a condition in a subject by administering a therapeutically effective dosage of site specific ACE inhibitor. In another embodiment, the condition is inflammation and/or immune response.

Abstract: The invention features a substantially pure preparation of a nucleic acid encoding a HY4 or a HY4-related gene. The invention further features transgenic plants encoding a HY4 gene having a shorter stem than substantially homozygous wild type nontransgenic plants; and, transgenic plants comprising complementary HY4 sequences having a longer stem than substantially homozygous wild type nontransgenic plants.