Abstract: The present invention relates to polyethylene glycol-modified form of kinin or derivative thereof and pharmaceutical use thereof. In one aspect, by PEG modification technology, the half-life of the kinin is greatly prolonged, meanwhile, the biological activity of the kinin is exerted, and the problem that pure kinin has extremely short half-life and therefore has no druggability is solved. PEG modifiers used include, but are not limited to, SPA, SCM and SS modifiers, and can be linear or branched PEG modifiers. In another aspect, the kinin variant has obvious advantages, such as the half-life is further prolonged while the affinity activity with receptor is maintained, and the in vivo efficacy of the PEG-modified kinin variant is superior to that of PEG-modified wild-type kinin, so that the druggability of the kinin is further improved.

Abstract: An automated robotic pipettor and reagent cocktail mixture maker includes a pipette rack to hold pipette tips; reagent racks to hold reagent containers; a buffer rack to hold buffer containers; one or more rotatable test tube mixers to hold one or more mixture test tubes; and an automated robotic arm having an automated syringe pump with an end effector to receive a disposable pipette tip. The automated robotic arm moves pipette tips while the automated syringe pump draws measures of liquid from the various containers into the pipette tip and expels it therefrom into a mixture test tube. The rotatable test tube mixer rotates the mixing tube to mix reagents and buffers together. A cooling system cools the buffers, the reagents, and the reagent mix. But for small openings to receive the pipette tip, a hinged cover covers over the buffers, reagents, and reagent mix to deter cross contamination.

Abstract: A method and an apparatus for improving voice call quality in an EPSFB (Evolved Packet System Fallback) scenario are provided, which are applied to the communication field. This method provides an optimization solution for refreshing a resource reservation state to resolve a problem of dual-terminal no sound, call drop, or call drop after no sound during a call between a caller terminal and a called terminal due to signaling disorder in the EPSFB scenario, effectively improving a success rate for refreshing a call state in the current scenario and ensuring a normal voice for a terminal in an abnormal scenario.

Abstract: This application relates to the field of communication technologies, and, to a call control method and device. The call control method includes: A first electronic device receives a first call from a second electronic device, and displays a first waiting-for-answering screen. A second call from a third electronic device is received before the first electronic device answers the first call. The first electronic device answers the first call in response to a first operation in the first waiting-for-answering screen. The first electronic device displays a second waiting-for-answering screen after the first call is answered. The first electronic device answers the second call in response to a second operation in the second waiting-for-answering screen. According to these technical solutions, after receiving a new call request during an ongoing call setup, directly rejecting the new call request can be avoided, thereby preventing missed calls in call conflict scenarios.

Abstract: Provided is a method for realizing the controlled release and sustained release of the activity of bioactive molecules and use for drugs. Provided is a PEG modifier of a specific structure. The PEG modifier can be widely applied to the controlled release and sustained release of the activity of various bioactive molecules. A conjugate is formed by reacting the PEG modifier of the specific type and structure with IL-2. In a certain in vitro condition or in vivo physiological condition, PEG gradually falls off from the conjugate and the activity of IL-2 is gradually released, so that a certain effective plasma concentration where bioactive molecules are relatively stable can be maintained, and thus the in vivo or in vitro sustained release and controlled release of the activity of the drug are realized.

Abstract: Provided is use of kinin or derivative thereof, in particular long-acting kinin or derivative thereof, in treating vascular cognitive impairment (VCI), post-stroke cognitive impairment (PSCI), or cerebral small vessel disease (CSVD). VCI and PSCI are generally associated with cognitive function impairment and psychoactive behavioral symptom. Drugs for treating cognitive impairment in VCI and PSCI include cholinesterase inhibitors, non-competitive N-methyl-D-asparagine receptor antagonists, and drugs for treating psychoactive behavioral symptom include antidepressants. Patients with chronic CSVD may have symptoms such as cognitive disorder, movement disorder, emotional disorder, defecation disorder and other symptoms. Cholinesterase inhibitors and non-competitive N-methyl-D-asparagine receptor antagonists can be used for cognitive disorder, and antidepressants are generally used for depression.

Abstract: Provided are low glycosylated kallikrein I with no or a small amount of glycosylation at the NFS sequence and polyethylene glycol modified product and pharmaceutical applications. KLK1 with lower glycosylation at NFS is more active than KLK1 with higher glycosylation at NFS. A recombinant KLK1 mutant without N-glycosylation at the NFS sequence is also provided, containing only two N-glycosylation sites at NMS and NHT. Glycosylation of the recombinant KLK1 mutant is relatively more consistent, the molecular weight of the product is relatively more homogeneous, the yield is higher, the purification process is simpler, and the biological activity is higher, and the quality is more controllable.

Abstract: A method for manufacturing a retroreflective sheet, provided with a retroreflective layer having retroreflective elements on one surface, a back face layer provided to face the retroreflective elements, a coupling portion to couple a part of the retroreflective elements and a part of the back face layer, the method including a preparation step of preparing a resin composition that has a viscosity capable of adhering over a predetermined time after application of predetermined energy, and completes curing after the predetermined time passes, a coating step of applying the resin composition forming the coupling portion on the retroreflective layer or the back face layer, an energy application step of applying the predetermined energy to the resin composition, and a bonding step of bonding the retroreflective layer and the back face layer via the resin composition to which the predetermined energy is applied before the predetermined time passes.

Abstract: A retroreflective sheet includes: a retroreflective layer (20) including a plurality of retroreflective elements (24) on one surface; a back face layer (40) provided to face the surface of the retroreflective layer (20) on the side of the retroreflective elements (24) and including a bonding portion (42) bonded to the retroreflective elements (24); and a plurality of particles (30) disposed between the retroreflective elements (24) and the back face layer (40). The bonding portion (42) is continuously formed to surround a plurality of capsule portions (46) in plan view. Voids (32) are formed between the retroreflective elements (24) and the back face layer (40) in the plurality of capsule portions (46).

Abstract: A retro-reflective sheet includes: a retro-reflective layer (20) including a plurality of retro-reflective elements (24) on one surface; and a back face layer (30) provided to face the surface of the retro-reflective layer on the retro-reflective elements side. A part of the retro-reflective layer and a part of the back face layer are bonded to each other via a coupling portion (34) colored in a color other than white. Voids (36) are formed between another part of the retro-reflective layer and another part of the back face layer. The color of the coupling portion is different from colors of layers provided on a side opposite to the back face layer side from the voids.

Abstract: A method for manufacturing a retroreflective sheet, provided with a retroreflective layer having retroreflective elements on one surface, a back face layer provided to face the retroreflective elements, a coupling portion to couple a part of the retroreflective elements and a part of the back face layer, the method including a preparation step of preparing a resin composition that has a viscosity capable of adhering over a predetermined time after application of predetermined energy, and completes curing after the predetermined time passes, a coating step of applying the resin composition forming the coupling portion on the retroreflective layer or the back face layer, an energy application step of applying the predetermined energy to the resin composition, and a bonding step of bonding the retroreflective layer and the back face layer via the resin composition to which the predetermined energy is applied before the predetermined time passes.

Abstract: A retroreflective sheet includes: a retroreflective layer (20) including a plurality of retroreflective elements (24) on one surface; a back face layer (40) provided to face the surface of the retroreflective layer (20) on the side of the retroreflective elements (24) and including a bonding portion (42) bonded to the retroreflective elements (24); and a plurality of particles (30) disposed between the retroreflective elements (24) and the back face layer (40). The bonding portion (42) is continuously formed to surround a plurality of capsule portions (46) in plan view. Voids (32) are formed between the retroreflective elements (24) and the back face layer (40) in the plurality of capsule portions (46).

Abstract: Provided are a retroreflective sheet (100) including: a retroreflective layer (20) including a plurality of retroreflective elements (24) on one surface; a back face layer(40) provided to face the retroreflective elements (24) and having a surface on a retroreflective elements (24) side at least a part of which is made of resin; a plurality of particles (30) disposed between the retroreflective elements (24) and the back face layer (40) and having a surface at least a part of which is made of resin; and voids formed between the retroreflective elements (24) and the back face layer (40), and a method for manufacturing the retroreflective sheet (100).

Abstract: A retroreflective sheeting includes a retroreflective layer 20 having a plurality of retroreflective elements 24 on a first face; a back face layer 40 provided opposite to a face of the retroreflective layer 20 on a side of the retroreflective element 24, the back face layer 40 having an attachment portion 42 attached to the retroreflective elements 24; a plurality of particles 30 arranged between the retroreflective elements 24 and the back face layer 40; and a void 32 formed between the retroreflective elements 24 and the plurality of particles 30.

Abstract: Disclosed herein are example embodiments for providing high power, narrow linewidth, high-stability laser sources. Particular embodiments are adapted for use in spin exchange optical pumping (SEOP).

Abstract: Disclosed herein are example embodiments for providing high power, narrow linewidth, high-stability laser sources. Particular embodiments are adapted for use in spin exchange optical pumping (SEOP).