Abstract: A device is provided for radially strengthening a polylactic acid tube, which includes a tubular mold, a rotating blade and a distal blade, wherein a rotating shaft of the rotating blade is arranged at an axial position of the tubular mold, a first end of the distal blade is movably connected to the rotating blade, and a second end of the distal blade is controlled by a control rod so as to open and close the distal blade. A strengthening method is provided, in which the device for radially strengthening a polylactic acid tube is used.

Abstract: The present disclosure belongs to the field of medical preparations, and particularly relates to a drug coating for an expandable balloon catheter and a preparation method therefor. The present disclosure selects two amphiphilic auxiliary materials of phospholipid and PEG, an outer layer of the phospholipid prevents a coating from being washed away by blood in a delivery process of a balloon, is dissolved with a cell membrane to realize a residence of a drug at a target position, and improves biocompatibility, and the hydrophilic excipient PEG enables a drug coating surface and a balloon surface to form an easy-to-strip state, such that the drug coating surface is separated from the balloon surface, and a balance of adhesion and stripping is realized.

Abstract: The present application provides a novel drug balloon catheter capable of controlling drug release, comprising a balloon, a catheter, and a drug coating, and wherein a surface of the balloon is coated with the drug coating, and the drug coating is divided into a first drug coating, a second drug coating, and a third drug coating; and release rates of a drug in the first drug coating, the second drug coating, and the third drug coating are different. By controlling a drug release period, a problem of a toxic reaction caused by a downstream blood vessel is solved, while the drug release period is prolonged, thereby effectively treating a blood vessel tear caused by over-dilation and improving a long-term effectiveness of a drug treatment.

Abstract: The present disclosure belongs to the technical field of medicines, and specifically, relates to a core-shell micelle microsphere, and a preparation method therefor and use thereof. The core-shell micelle microsphere of the present disclosure has an outer layer shell composed of an amphiphilic lipid, an inner layer shell formed by a hydrophilic chain polymer, and a drug molecule inner core wrapped by a copolymer with a net structure. A drug may be effectively transported through the two-layer shell structure, such that a loss of the drug in a transportation process is reduced, and a utilization rate of the drug is improved. A slow release of the drug is realized by using a wrapped drug molecule as the inner core.

Abstract: The present invention relates to the field of medical instruments, more particularly to a pulse balloon and use thereof. The pulse balloon comprises a balloon body and an inner tube, wherein the balloon body comprises an insulating layer and a balloon wall. The insulating layer is arranged on the balloon body, when the balloon body operates, the balloon body is filled with an electrolyte so that an electrode releases high-pulse piezoelectricity to generate pulses, the electrolyte spreads to drive the vibration of the balloon, so that most of electrical energy is converted into mechanical energy to break down a calcified area of a blood vessel, and the residual high voltage is blocked by the insulating layer.

Abstract: A device is provided for radially strengthening a polylactic acid tube, which includes a tubular mold, a rotating blade and a distal blade, wherein a rotating shaft of the rotating blade is arranged at an axial position of the tubular mold, a first end of the distal blade is movably connected to the rotating blade, and a second end of the distal blade is controlled by a control rod so as to open and close the distal blade. A strengthening method is provided, in which the device for radially strengthening a polylactic acid tube is used.

Abstract: The present invention provides a preparation method for a drug-coated balloon controllable in drug metabolism. A drug receptor protein inhibitor is mixed with drugs, water and ethanol to obtain a medicinal liquid, the medicinal liquid is sprayed onto the surface of a balloon back and forth by means of an ultrasonic spraying device, and drying is performed so as to prepare the drug-coated balloon. The drug receptor protein inhibitor can also be replaced with other agents such as a drug metabolism isoenzyme inhibitor, a drug metabolism isoenzyme inducer, or a mixture of the drug receptor protein inhibitor and the drug metabolism isoenzyme inhibitor for preparing the medicinal liquid, and a drug metabolic cycle of the drug-coated balloon can be further adjusted and controlled by adjusting the ratio of the addition quantity of the drug receptor protein inhibitor or the other agents to the drugs.