Patents by Inventor Cheol Hwa HONG

Cheol Hwa HONG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Artificial antigen-presenting cell prepared from HLA-null cell line by using multiplex CRISPR-CAS9 system and use thereof
    Patent number: 11859207
    Abstract: The present invention relates to an artificial antigen-presenting cell prepared from an HLA-null cell line by using a multiplex CRISPR-Cas9 system and the use thereof and, more particularly, to a novel artificial antigen-presenting cell which includes the ability to present antigens of HLA class I and a co-stimulatory molecule group transferred from an HLA-A, -B, -C null cell line generated using a multiplex CRISPR-Cas9 system and to stimulate T cells, an immunotherapeutic agent using the same, and the use thereof for treating tumors, pathogenic infections, and autoimmune diseases.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: January 2, 2024
    Assignee: The Catholic Uiversity of Korea Industry-Academic Cooperation Foundation
    Inventors: Tai Gyu Kim, Hyun Jung Sohn, Cheol Hwa Hong
  • ARTIFICIAL ANTIGEN-PRESENTING CELL PREPARED FROM HLA-NULL CELL LINE BY USING MULTIPLEX CRISPR-CAS9 SYSTEM AND USE THEREOF
    Publication number: 20190309260
    Abstract: The present invention relates to an artificial antigen-presenting cell prepared from an HLA-null cell line by using a multiplex CRISPR-Cas9 system and the use thereof and, more particularly, to a novel artificial antigen-presenting cell which includes the ability to present antigens of HLA class I and a co-stimulatory molecule group transferred from an HLA-A, -B, -C null cell line generated using a multiplex CRISPR-Cas9 system and to stimulate T cells, an immunotherapeutic agent using the same, and the use thereof for treating tumors, pathogenic infections, and autoimmune diseases.
    Type: Application
    Filed: December 1, 2017
    Publication date: October 10, 2019
    Inventors: Tai Gyu KIM, Hyun Jung SOHN, Cheol Hwa HONG