Patents by Inventor Cheol-Kyong Kim

Cheol-Kyong Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the preparation of 2?-deoxy-2?,2?-difluorocytidine
    Patent number: 7799907
    Abstract: Provided is an improved method for stereoselectively preparing 2?-deoxy-2?,2?-difluorocytidine of formula (I), which includes reacting a 1-halo ribofuranose compound with a nucleobase of formula (IV) in a solvent to obtain a nucleo side of formula (II) with removal of a silyl halide ((alkyl)3SiX (X=halide)); and deprotecting the nucleoside of formula (II) to obtain 2?-deoxy-2?,2?-difluorocytidine of formula (I). 2?-Deoxy-2?,2?-difluorocytidine of formula (I) is effective for treating various cancers such as non-small cell lung (NSCLC), pancreatic, bladder, breast or ovarian cancers.
    Type: Grant
    Filed: December 29, 2005
    Date of Patent: September 21, 2010
    Assignee: Hanmi Pharm. Co., Ltd
    Inventors: Jaeheon Lee, Gha Seung Park, Moonsub Lee, Hyo-Jeong Bang, Jae Chul Lee, Cheol Kyong Kim, Chang-Ju Choi, Han Kyong Kim, Hoe Chul Lee, Young-Kil Chang, Gwan Sun Lee
  • Method for the preparation of D-erythro-2,2-difluoro-2-deoxy-1-oxoribose derivative
    Patent number: 7638642
    Abstract: 3R-carboxylate enantiomer derivative of formula (III) can be prepared easily and selectively by the method of the present invention, and a highly pure D-erythro-2,2-difluoro-2-deoxy-1-oxoribose derivative can be prepared efficiently from the compound of formula (III) as an intermediate.
    Type: Grant
    Filed: June 23, 2005
    Date of Patent: December 29, 2009
    Assignee: Hanmi Pharm, Co., Ltd
    Inventors: Jaeheon Lee, Gha-Seung Park, Moonsub Lee, Cheol-Kyong Kim, Jae-Chul Lee, Young-Kil Chang, Gwan-Sun Lee
  • Method for the Preparation of D-Erythro-2,2-Difluoro-2-Deoxy-1-Oxoribose Derivative
    Publication number: 20080058509
    Abstract: 3R-carboxylate enantiomer derivative of formula (III) can be prepared easily and selectively by the method of the present invention, and a highly pure D-erythro-2,2-difluoro-2-deoxy-1-oxoribose derivative can be prepared efficiently from the compound of formula (III) as an intermediate.
    Type: Application
    Filed: June 23, 2005
    Publication date: March 6, 2008
    Applicant: HANMI PHARM, CO., LTD.
    Inventors: Jaeheon Lee, Gha-Seung Park, Moonsub Lee, Cheol-Kyong Kim, Jae-Chul Lee, Young-Kil Chang, Gwan-Sun Lee