Patents by Inventor Cheol-Sang Hwang

Cheol-Sang Hwang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of purifying native ubiquitin
    Patent number: 11459555
    Abstract: The present invention relates to a method of purifying native ubiquitin without acid or heat treatment. The method presented here is designed to overcome limitations of acid or heat based ubiquitin purification in two different points of view. First, it decreases a chance of mixing other proteins resistant to acids or heat. Second, it includes no harsh condition, which might denature the ubiquitin. As a result, the purification of native ubiquitin becomes possible. The ubiquitin obtained herein is expected to be used for various purposes in technical fields.
    Type: Grant
    Filed: December 21, 2020
    Date of Patent: October 4, 2022
    Assignee: POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION
    Inventors: Cheol-Sang Hwang, The Kha Nguyen, Da-Som Kim
  • METHOD OF PURIFYING HIGH-PURITY UBIQUITIN
    Publication number: 20210198651
    Abstract: The present invention relates to a method of purifying high-purity ubiquitin without acid or heat treatment. The method presented here is designed to overcome limitations of acid or heat based ubiquitin purification in two different points of view. First, it decreases a chance of mixing other proteins resistant to acids or heat. Second, it includes no harsh condition, which might denature the ubiquitin. As a result, the purification of native ubiquitin becomes possible. The ubiquitin obtained herein is expected to be used for various purposes in technical fields.
    Type: Application
    Filed: December 21, 2020
    Publication date: July 1, 2021
    Inventors: Cheol-Sang Hwang, The Kha Nguyen, Da-Som Kim
  • Discovery and applications of the proteolytic function of N-terminal acetylation of cellular proteins
    Patent number: 8999896
    Abstract: Screening assays that allow for the identification of agents that modulate the activity of N-terminal acetylation of a polypeptide and the Doa10 branch of the N-end rule pathway are provided. Also provided are methods of using an agent that modulates the activity of N-terminal acetylation of a polypeptide and the Doa10 branch of the N-end rule pathway to increase or decrease protein degradation in a cell, and to modulate physiologic and pathologic associated with N-terminal acetylation of a polypeptide and the Doa10 branch of the N-end rule pathway.
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: April 7, 2015
    Assignee: California Institute of Technology
    Inventors: Cheol-Sang Hwang, Anna Shemorry, Alexander Varshavsky
  • Discovery And Applications Of The Proteolytic Function of N-Terminal Acetylation Of Cellular Proteins
    Publication number: 20110230370
    Abstract: Screening assays that allow for the identification of agents that modulate the activity of N-terminal acetylation of a polypeptide and the Doa10 branch of the N-end rule pathway are provided. Also provided are methods of using an agent that modulates the activity of N-terminal acetylation of a polypeptide and the Doa10 branch of the N-end rule pathway to increase or decrease protein degradation in a cell, and to modulate physiologic and pathologic associated with N-terminal acetylation of a polypeptide and the Doa10 branch of the N-end rule pathway.
    Type: Application
    Filed: January 14, 2011
    Publication date: September 22, 2011
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Cheol-Sang Hwang, Anna Shemorry, Alexander Varshavsky