Patents by Inventor Cherie Holcomb

Cherie Holcomb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Successive capture of nucleic acid by magnetic glass particles
    Patent number: 10174308
    Abstract: Provided herein are methods and components for successive capture of nucleic acids using magnetic glass particles.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: January 8, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Alan Casilla, Jennifer Griswold, Cherie Holcomb, Trevor Hryce, Karan Kampani, Sharon Legaspi
  • METHODS AND COMPOSITIONS FOR PURIFYING DOUBLE STRANDED NUCLEIC ACIDS
    Publication number: 20180073011
    Abstract: Provided herein are methods and compositions to effectively isolate short, double-stranded nucleic acids on magnetic glass particles.
    Type: Application
    Filed: September 12, 2017
    Publication date: March 15, 2018
    Inventors: Priya Bellare, Cherie Holcomb, Alan Casilla, Qiao Ruan, Trevor Hryce, Karan Kampani, Igor Kozlov
  • Non-invasive early detection of solid organ transplant rejection by quantitative analysis of mixtures by deep sequencing of HLA gene amplicons using next generation systems
    Patent number: 9752189
    Abstract: The invention is a method of detecting or assessing solid organ graft (transplant) rejection by detecting donor-specific HLA alleles in a blood sample of a graft (transplant) recipient. The invention further comprises a method of detecting the presence of maternal cells in a blood sample of an offspring.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: September 5, 2017
    Assignees: Roche Molecular Systems, Inc., The Scripps Research Institute
    Inventors: Henry Erlich, Bryan Hoglund, Cherie Holcomb, Priscilla Moonsamy, Nick Newton, Melinda Rastrou, Nancy Schoenbrunner, Alison Tsan, Daniel Salomon
  • SUCCESSIVE CAPTURE OF NUCLEIC ACID BY MAGNETIC GLASS PARTICLES
    Publication number: 20170191053
    Abstract: Provided herein are methods and components for successive capture of nucleic acids using magnetic glass particles.
    Type: Application
    Filed: January 4, 2017
    Publication date: July 6, 2017
    Inventors: Alan Casilla, Jennifer Griswold, Cherie Holcomb, Trevor Hryce, Karan Kampani, Sharon Legaspi
  • NON-INVASIVE EARLY DETECTION OF SOLID ORGAN TRANSPLANT REJECTION BY QUANTITATIVE ANALYSIS OF HLA GENE AMPLICONS
    Publication number: 20160017421
    Abstract: The invention is a method of detecting or assessing solid organ graft (transplant) rejection and acute dysfunction—no rejection condition by detecting donor-specific HLA alleles in a blood sample of a graft (transplant) recipient.
    Type: Application
    Filed: November 3, 2014
    Publication date: January 21, 2016
    Inventors: Henry Erlich, Bryan Hoglund, Cherie Holcomb, Priscilla Moonsamy, Nick Newton, Melinda Rastrou, Daniel Salomon, Nancy Shoenbrunner, Alison Tsan
  • METHOD OF DETERMINING THE FRACTION OF FETAL DNA IN MATERNAL BLOOD USING HLA MARKERS
    Publication number: 20150203914
    Abstract: The invention comprises a method of determining the fraction of fetal DNA in maternal blood or plasma using HLA locus wherein the maternal and fetal HLA alleles are detected and quantified by clonal or digital methods.
    Type: Application
    Filed: May 9, 2014
    Publication date: July 23, 2015
    Applicant: Roche Molecular Systems
    Inventors: Henry Erlich, Bryan Hoglund, Cherie Holcomb, Priscilla Moonsamy, Nick Newton, Melinda Rastrou, Nancy Schoenbrunner, Alison Tsan
  • NON-INVASIVE EARLY DETECTION OF SOLID ORGAN TRANSPLANT REJECTION BY QUANTITATIVE ANALYSIS OF MIXTURES BY DEEP SEQUENCING OF HLA GENE AMPLICONS USING NEXT GENERATION SYSTEMS
    Publication number: 20140336056
    Abstract: The invention is a method of detecting or assessing solid organ graft (transplant) rejection by detecting donor-specific HLA alleles in a blood sample of a graft (transplant) recipient. The invention further comprises a method of detecting the presence of maternal cells in a blood sample of an offspring.
    Type: Application
    Filed: May 8, 2014
    Publication date: November 13, 2014
    Applicants: Roche Molecular Systems, The Scripps Research Institute
    Inventors: Henry Erlich, Bryan Hoglund, Cherie Holcomb, Priscilla Moonsamy, Nick Newton, Melinda Rastrou, Nancy Schoenbrunner, Alison Tsan, Daniel Salomon
  • Methods and Compositions for Very High Resolution Genotyping of HLA
    Publication number: 20140141436
    Abstract: The invention is a method of determining HLA genotype for HLA-A, HLA-B, HLA-C, DQB1, DRB1, DRB3, DRB4, DRB5, DPA1 and DPB1. Reagents and kits are also disclosed.
    Type: Application
    Filed: August 21, 2013
    Publication date: May 22, 2014
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Henry Erlich, Bryan Hoglund, Cherie Holcomb, Priscilla Moonsamy
  • Multiplex quantitative nucleic acid amplification and melting assay
    Patent number: 8039215
    Abstract: The invention is a single-tube multiplex assay, capable of simultaneously amplifying, detecting and quantifying multiple nucleic acid targets, using multiple hybridization probes, labeled with the same fluorescent reporter label, but each having a distinct melting temperature. The assay can be further multiplexed with the use of multiple sets of hybridization probes, each set labeled with a separate fluorescent reporter label.
    Type: Grant
    Filed: March 10, 2009
    Date of Patent: October 18, 2011
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Russell Higuchi, Cherie Holcomb
  • SENP1 as a marker for cancer
    Patent number: 7939251
    Abstract: The present invention provides methods of detecting cancer cells by detecting the quantity of SENP1 and/or telomerase in a sample.
    Type: Grant
    Filed: May 2, 2005
    Date of Patent: May 10, 2011
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Cherie Holcomb, Russell Higuchi
  • System and method for detection of HLA Variants
    Publication number: 20100261189
    Abstract: A method for detecting one or more HLA sequence types is described that comprises the steps of: amplifying a plurality of first amplicons from a double stranded nucleic acid sample, wherein the first amplicons are amplified with a plurality of pairs of nucleic acid primers that define exons 2 and 3 of both strands of HLA loci from the group consisting of HLA-A, HLA-B, and HLA-C; amplifying the first amplicons to produce a plurality of populations of second amplicons, wherein each population of second amplicons is clonally amplified from one of the first amplicons; sequencing the plurality of populations of second amplicons to generate a nucleic acid sequence composition for each of the plurality of second amplicons; and detecting variation in the sequence composition from one or more of the second amplicons for one or more of the HLA loci.
    Type: Application
    Filed: April 12, 2010
    Publication date: October 14, 2010
    Inventors: Gordon Bentley, Henry A. Erlich, Russell Gene Higuchi, Cherie Holcomb
  • Multiplex Quantitative Nucleic Acid Amplification and Melting Assay
    Publication number: 20100233686
    Abstract: The invention is a single-tube multiplex assay, capable of simultaneously amplifying, detecting and quantifying multiple nucleic acid targets, using multiple hybridization probes, labeled with the same fluorescent reporter label, but each having a distinct melting temperature. The assay can be further multiplexed with the use of multiple sets of hybridization probes, each set labeled with a separate fluorescent reporter label.
    Type: Application
    Filed: March 10, 2009
    Publication date: September 16, 2010
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: RUSSELL HIGUCHI, CHERIE HOLCOMB
  • SENP1 as a marker for cancer
    Patent number: 7776539
    Abstract: The present invention provides methods of detecting cancer cells by detecting the quantity of SENP1 and/or telomerase in a sample.
    Type: Grant
    Filed: May 6, 2008
    Date of Patent: August 17, 2010
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Cherie Holcomb, Russell Higuchi
  • SENP1 as a marker for cancer
    Publication number: 20090162846
    Abstract: The present invention provides methods of detecting cancer cells by detecting the quantity of SENP1 and/or telomerase in a sample.
    Type: Application
    Filed: May 6, 2008
    Publication date: June 25, 2009
    Applicant: Roche Molecular Systems, Inc
    Inventors: Cherie Holcomb, Russell Higuchi, Nancy J. Schoenbrunner
  • SENP1 as a marker for cancer
    Publication number: 20060014171
    Abstract: The present invention provides methods of detecting cancer cells by detecting the quantity of SENP1 and/or telomerase in a sample.
    Type: Application
    Filed: May 2, 2005
    Publication date: January 19, 2006
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Cherie Holcomb, Russell Higuchi, Nancy Schoenbrunner