Abstract: The present disclosure provides for spherical microbeads, methods of making, and methods of use. The spherical microbeads can be tailored to deliver one or more agents over a desired time frame (e.g., short burst or extended-release or combinations thereof). For example, spherical microbeads can be used for the extended-release of oxygen. The spherical microbeads are amendable for an injectable approach and/or ease of integration within cellular implants due in part to their spherical dimensions and size.

Abstract: The present disclosure provides for oxygen generating and free radical scavenging biomaterials, an article including the oxygen generating and free radical scavenging biomaterial, wound healing dressings or structures (e.g., bandage) that have the characteristic of generating oxygen and having redox modulating capabilities. In particular, the wound healing dressing can have the characteristics of being anti-inflammatory, antioxidant, and pro-healing for extended periods of time (e.g., at least 10 days, at least 30 days).

Abstract: A protective coating for covering a biological material, the protective coating having a plurality of interconnected layers covalently bonded to each other. The plurality of interconnected layers can include at least one hyperbranched polymeric material, and at least one dendrimer. A method of forming a protective coating for covering a biological material, the method can include depositing a plurality of interconnected layers, which are covalently bonded to each other. The plurality of interconnected layers can include at least one hyperbranched polymeric material, and at least one dendrimer.

Abstract: A biocompatible capsule comprising a biological material encapsulated by a covalently stabilized coating and a method of making the same are disclosed. The biological material can be a material selected from the group consisting of cells, such as islets of Langerhans, pharmaceuticals, and biological agents. The coating can be formed by reacting an alginate-[polyalkylene glycol (PAG)-X1]n, and a multi-functional PAG-X2, to form covalent bonds, wherein n is an integer greater than 0, a first one of X1 and X2 is N3, and a second one of X1 and X2 is selected from the group consisting of: wherein R1=CH3, CH2CH3, CH(CH3)2, R2=N(CH3)2, OCH3, OH, CH3, H, F, Cl, Br or NO2, and R3=OCH3, CH3, H, F, Cl or NO2.

Abstract: A protective coating for covering a biological material, the protective coating having a plurality of interconnected layers covalently bonded to each other. The plurality of interconnected layers can include at least one hyperbranched polymeric material, and at least one dendrimer. A method of forming a protective coating for covering a biological material, the method can include depositing a plurality of interconnected layers, which are covalently bonded to each other. The plurality of interconnected layers can include at least one hyperbranched polymeric material, and at least one dendrimer.

Abstract: A biocompatible capsule comprising a biological material encapsulated by a covalently stabilized coating and a method of making the same are disclosed. The biological material can be a material selected from the group consisting of cells, such as islets of Langerhans, pharmaceuticals, and biological agents. The coating can be formed by reacting an alginate-[polyalkylene glycol (PAG)-X1]n, and a multi-functional PAG-X2, to form covalent bonds, wherein n is an integer greater than 0, a first one of X1 and X2 is N3, and a second one of X1 and X2 is selected from the group consisting of: wherein R1=CH3, CH2CH3, CH(CH3)2, R2=N(CH3)2, OCH3, OH, CH3, H, F, Cl, Br or NO2, and R3=OCH3, CH3, H, F, Cl or NO2.