Patents by Inventor Cherng-ju Kim
Cherng-ju Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10071060Abstract: A tablet for the controlled release of a drug. The tablet is in the form of an asymmetrically coated tablet so that immediate release or time-delayed release times can be precisely controlled and the extended release slab may provide zero-order or first-order extended release and pulsatile release depending on the excipients used in the tablet formulations. The core of the tablet is coated with an asymmetrical coating, that is, a coating with regions having different properties. The coatings may include drugs in varying concentrations. Further, different regions of the coating may have different rates of dissolution. The core of the tablet may be provided with a constant cross-sectional area along a longitudinal length of the tablet, a coating having a first region with a more rapid rate of dissolution than a second region. The dissolution of the first region exposes only the cross-sectional area to the dissolution medium.Type: GrantFiled: May 30, 2006Date of Patent: September 11, 2018Assignee: BioVentures, LLCInventor: Cherng-ju Kim
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Patent number: 8034382Abstract: The disclosure provides a method to form sustained release drug-containing microparticles with a biodegradable polymer. The method involves forming a polymer-drug-organic solvent phase, and dispersing the polymer-drug-organic solvent phase in an aqueous suspension of an inorganic gel, which may be hydroxyapatite. The hydroxyapatite appears to coat the polymer-drug-solvent droplets to prevent them coalescing. The solvent then evaporates with stirring of the dispersion, at which time the droplets solidify to drug-containing microparticles. The inorganic gel allows suitably small microparticles to form without use of an organic emulsifier.Type: GrantFiled: July 31, 2008Date of Patent: October 11, 2011Assignee: The Board of Trustees of the University of ArkansasInventor: Cherng-Ju Kim
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Patent number: 7713549Abstract: A tablet for the controlled release of a pharmaceutically active ingredient. The tablet is in the form of coated DST's and MLDST's so that immediate release or time-delayed release can be achieved. Further, such extended release DST's and MLDST's may provide zero order or first order extended release kinetics depending on the excipients and types of pharmaceutically active ingredients in the tablet formulation. The time delay coating is made of high molecular weight water soluble polymers so that dose dumping can be minimized even when the hydrated surface of the DST and MLDST peels off. A second coating of low molecular weight water soluble polymer with a pharmaceutically active ingredient dispersed therein provides for pulsatile release.Type: GrantFiled: June 30, 2006Date of Patent: May 11, 2010Assignee: Board of Trustees of the University of ArkansasInventor: Cherng-ju Kim
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Publication number: 20100105637Abstract: The invention involves sustained-release pharmaceutical compositions containing a water-soluble ionic small molecule pharmaceutical agent complexed with an oppositely charged surfactant, particularly a natural bile surfactant. The complexes are sustained-release ionic complexes. The complexes release the ionic pharmaceutical agents into aqueous solution slowly and with zero-order kinetics. Thus, they can be formulated into sustained-release pharmaceutical compositions.Type: ApplicationFiled: October 22, 2009Publication date: April 29, 2010Inventor: Cherng-ju Kim
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Publication number: 20100028454Abstract: The disclosure provides a method to form sustained release drug-containing microparticles with a biodegradable polymer. The method involves forming a polymer-drug-organic solvent phase, and dispersing the polymer-drug-organic solvent phase in an aqueous suspension of an inorganic gel, which may be hydroxyapatite. The hydroxyapatite appears to coat the polymer-drug-solvent droplets to prevent them coalescing. The solvent then evaporates with stirring of the dispersion, at which time the droplets solidify to drug-containing microparticles. The inorganic gel allows suitably small microparticles to form without use of an organic emulsifier.Type: ApplicationFiled: July 31, 2008Publication date: February 4, 2010Applicant: The Board of Trustees of the University of ArkansasInventor: Cherng-Ju Kim
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Publication number: 20080003287Abstract: A tablet for the controlled release of a pharmaceutically active ingredient. The tablet is in the form of coated DST's and MLDST's so that immediate release or time-delayed release can be achieved. Further, such extended release DST's and MLDST's may provide zero order or first order extended release kinetics depending on the excipients and types of pharmaceutically active ingredients in the tablet formulation. The time delay coating is made of high molecular weight water soluble polymers so that dose dumping can be minimized even when the hydrated surface of the DST and MLDST peels off. A second coating of low molecular weight water soluble polymer with a pharmaceutically active ingredient dispersed therein provides for pulsatile release.Type: ApplicationFiled: June 30, 2006Publication date: January 3, 2008Inventor: Cherng-ju Kim
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Publication number: 20070042041Abstract: The invention involves sustained-release pharmaceutical compositions containing a water-soluble ionic small molecule pharmaceutical agent complexed with an oppositely charged surfactant, particularly a natural bile surfactant. The complexes are sustained-release ionic complexes. The complexes release the ionic pharmaceutical agents into aqueous solution slowly and with zero-order kinetics. Thus, they can be formulated into sustained-release pharmaceutical compositions.Type: ApplicationFiled: August 17, 2005Publication date: February 22, 2007Applicant: Board of Trustees of the University of ArkansasInventor: Cherng-Ju Kim
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Publication number: 20070009599Abstract: A tablet for the controlled release of a drug. The tablet is in the form of an asymmetrically coated tablet so that immediate release or time-delayed release times can be precisely controlled and the extended release slab may provide zero-order or first-order extended release and pulsatile release depending on the excipients used in the tablet formulations. The core of the tablet is coated with an asymmetrical coating, that is, a coating with regions having different properties. The coatings may include drugs in varying concentrations. Further, different regions of the coating may have different rates of dissolution. The core of the tablet may be provided with a constant cross-sectional area along a longitudinal length of the tablet, a coating having a first region with a more rapid rate of dissolution than a second region. The dissolution of the first region exposes only the cross-sectional area to the dissolution medium.Type: ApplicationFiled: May 30, 2006Publication date: January 11, 2007Inventor: Cherng-ju Kim
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Publication number: 20050025829Abstract: A pharmaceutical composition in the form of a perforated tablet comprising one or more than one enteric polymer and a drug, where the enteric polymer is substantially hydrophobic and substantially soluble in a substantially aqueous environment above a pH of about 5. The pharmaceutical composition can additionally comprise one or more than one layer, and can additionally comprise one or more than one binder.Type: ApplicationFiled: July 29, 2003Publication date: February 3, 2005Inventor: Cherng-Ju Kim
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Patent number: 6110500Abstract: A tablet for the controlled release of an active pharmaceutical ingredient. The tablet comprises a core having a donut-like configuration with a cylindrical hole extending through the center of the core. The core of the body comprises at least one active pharmaceutical agent and at least one hydrophilic, water-soluble, polymeric carrier. The core is coated with a hydrophobic, water-insoluble material covering all of the core except that which is defined by the cylindrical hole. Also included is a method of preparing a tablet for the controlled release of an active ingredient. The method comprises the steps of blending an active pharmaceutical ingredient, a water-soluble hydrophilic, polymeric carrier, and optionally an excipient, to form a mix; compressing the mix; punching a tablet from the mix; coating the tablet in a water insoluble, hydrophobic coating, then drilling a hole through the coated tablet.Type: GrantFiled: March 25, 1998Date of Patent: August 29, 2000Assignee: Temple UniversityInventor: Cherng-ju Kim
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Patent number: 5945125Abstract: A controlled release tablet including a pharmaceutical agent and an excipient. The excipient includes at least about 60% of a water swellable polymer and a lubricant. The water swellable polymer is chosen such that the swelling rate of the polymer is equal to the dissolution rate of the swollen polymer. The excipient may also include such other ingredients as diluents, fillers, binders, solubilizers, emulsifiers, and other pharmacologically inactive compounds. The polymer is chosen with the pharmaceutical agent in mind such that the tablet will be fully dissolved at the same time that the last of the pharmaceutical agent is released.Type: GrantFiled: June 21, 1996Date of Patent: August 31, 1999Assignee: Temple UniversityInventor: Cherng-ju Kim