Patents by Inventor Cheryl A. Grice

Cheryl A. Grice has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MAGL INHIBITORS
    Publication number: 20240018120
    Abstract: Provided herein are substituted 1,1,1,3,3,3-hexafluoropropan-2-yl 6-azaspiro[2.5]octane-6-carboxylate compounds and pharmaceutical compositions comprising said compounds. The compounds and compositions provided herein are useful as inhibitors of MAGL. Furthermore, the compounds and compositions as provided herein are useful for the treatment of diseases and disorders benefiting from the inhibition of MAGL.
    Type: Application
    Filed: November 12, 2021
    Publication date: January 18, 2024
    Inventors: John J.M. WIENER, Cheryl A. GRICE, Daniel J. BUZARD, Justin S. CISAR, Olivia Delene WEBER, Amy ALLAN, Nicholas RAFFAELE, Jeanne V. MOODY, Michael B. SHAGHAFI
  • CRYSTALLINE FORMS OF A MAGL INHIBITOR
    Publication number: 20230357190
    Abstract: Described herein is new crystalline forms of the MAGL inhibitor 1,1,1,3,3,3-Hexafluoropropan-2-yl (S)-1-(pyridazin-3-ylcarbamoyl)-6-azaspiro[2.5]octane-6-carboxylate.
    Type: Application
    Filed: May 3, 2023
    Publication date: November 9, 2023
    Inventors: Thomas VETTER, John J.M. WIENER, Cheryl A. GRICE, Daniel J. BUZARD, Justin S. CISAR, Olivia Delene WEBER, Amy ALLAN, Nicholas RAFFAELE, Jeanne V. MOODY, Michael B. SHAGHAFI
  • CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20230312499
    Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.
    Type: Application
    Filed: November 8, 2022
    Publication date: October 5, 2023
    Inventors: Justin S. CISAR, Cheryl A. GRICE, Todd K. JONES, Micah J. NIPHAKIS, Jae Won CHANG, Kenneth M. LUM, Benjamin F. CRAVATT
  • SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS
    Publication number: 20230286941
    Abstract: This disclosure is drawn to pyridine derivatives, compositions thereof, and associated methods, useful for inhibition of SARM1 activity and/or for treating or preventing neurological disorders.
    Type: Application
    Filed: March 3, 2023
    Publication date: September 14, 2023
    Inventors: Rao KOLLURI, Christopher Michael TEGLEY, Liusheng ZHU, Sean Pomeroy BROWN, Charles Howard REYNOLDS, Andrew Stewart TASKER, Cheryl A. GRICE
  • CRYSTALLINE FORMS OF A MAGL INHIBITOR
    Publication number: 20230265095
    Abstract: Described herein are new crystalline forms of the MAGL inhibitor 1-(1-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)b enzyl)-1,8-diazaspiro[4.5]decane-8-carbonyl)-1H-pyrazole-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: November 1, 2022
    Publication date: August 24, 2023
    Inventors: Thomas VETTER, Martin JUHL, HEIDI LOPEZ DE DIEGO, Cheryl A. GRICE, John J.M. WIENER, Daniel J. BUZARD, Amy ALLAN, Susana DEL RIO GANCEDO, Samuel George ANDREW, Antonio CINCOTTI, Adam Ross PATTERSON, Richard James EDWARDS
  • PYRAZOLE MAGL INHIBITORS
    Publication number: 20230219897
    Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of monoacylglycerol lipase (MAGL). Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Application
    Filed: March 16, 2023
    Publication date: July 13, 2023
    Inventors: Cheryl A. GRICE, John J.M. WIENER, Olivia D. WEBER, Katharine K. DUNCAN
  • MAGL inhibitors
    Patent number: 11691975
    Abstract: Provided herein are spirocyclic and fused bicyclic carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: June 9, 2021
    Date of Patent: July 4, 2023
    Assignee: H. LUNDBECKA/S
    Inventors: Cheryl A. Grice, Daniel J. Buzard, Michael B. Shaghafi
  • Pyrazole MAGL inhibitors
    Patent number: 11655217
    Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising the same. The compounds and compositions are useful as modulators of monoacylglycerol lipase (MAGL). Furthermore, the compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: May 23, 2023
    Assignee: H. LUNDBECK A/S
    Inventors: Cheryl A. Grice, John J. M. Wiener, Olivia D. Weber, Katharine K. Duncan
  • Substituted pyridine derivatives as SARM1 inhibitors
    Patent number: 11629136
    Abstract: This disclosure is drawn to pyridine derivatives, compositions thereof, and associated methods, useful for inhibition of SARM1 activity and/or for treating or preventing neurological disorders.
    Type: Grant
    Filed: July 27, 2022
    Date of Patent: April 18, 2023
    Assignee: NURA BIO, INC.
    Inventors: Rao Kolluri, Christopher Michael Tegley, Liusheng Zhu, Sean Pomeroy Brown, Charles Howard Reynolds, Andrew Stewart Tasker, Cheryl A. Grice
  • SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS
    Publication number: 20230105696
    Abstract: This disclosure is drawn to pyridine derivatives, compositions thereof, and associated methods, useful for inhibition of SARM1 activity and/or for treating or preventing neurological disorders.
    Type: Application
    Filed: July 27, 2022
    Publication date: April 6, 2023
    Inventors: Rao KOLLURI, Christopher Michael TEGLEY, Liusheng ZHU, Sean Pomeroy BROWN, Charles Howard REYNOLDS, Andrew Stewart TASKER, Cheryl A. GRICE
  • Carbamate compounds and methods of making and using same
    Patent number: 11530189
    Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.
    Type: Grant
    Filed: March 8, 2021
    Date of Patent: December 20, 2022
    Assignees: H. LUNDBECKA/S, THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Justin S. Cisar, Cheryl A. Grice, Todd K. Jones, Micah J. Niphakis, Jae Won Chang, Kenneth M. Lum, Benjamin F. Cravatt
  • MAGL inhibitors
    Patent number: 11434222
    Abstract: Provided herein are substituted 1,1,1,3,3,3-hexafluoropropan-2-yl 6-azaspiro[2.5]octane-6-carboxylate compounds and pharmaceutical compositions comprising said compounds. The compounds and compositions provided herein are useful as inhibitors of MAGL. Furthermore, the compounds and compositions as provided herein are useful for the treatment of diseases and disorders benefiting from the inhibition of MAGL.
    Type: Grant
    Filed: November 11, 2021
    Date of Patent: September 6, 2022
    Assignee: H. LUNDBECK A/S
    Inventors: John J. M. Wiener, Cheryl A. Grice, Daniel J. Buzard, Justin S. Cisar, Olivia Delene Weber, Amy Allan, Nicholas Raffaele, Jeanne Moody, Michael B. Shaghafi
  • CRYSTALLINE FORMS OF A MAGL INHIBITOR
    Publication number: 20220235037
    Abstract: Described herein is the MAGL inhibitor 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)piperazine-1-carboxylate, including crystalline forms and pharmaceutically acceptable salts and solvates thereof.
    Type: Application
    Filed: September 8, 2021
    Publication date: July 28, 2022
    Inventors: Cheryl A. GRICE, Todd K. JONES, Kurt G. GRIMM, Jacqueline Lorayne BLANKMAN, Channing Rodney BEALS
  • ABHD12 INHIBITORS AND METHODS OF MAKING AND USING SAME
    Publication number: 20220213074
    Abstract: Provided herein are compounds and compositions useful as modulators of ABHD12. Furthermore, the subject compounds and compositions are useful as immunotherapies in treating, for instance, cancer or infectious diseases.
    Type: Application
    Filed: May 13, 2020
    Publication date: July 7, 2022
    Inventors: Cheryl A. GRICE, Jeanne V. MOODY, Daniel J. BUZARD, Justin S. CISAR
  • MAGL INHIBITORS
    Publication number: 20220153721
    Abstract: Provided herein are substituted 1,1,1,3,3,3-hexafluoropropan-2-yl 6-azaspiro[2.5]octane-6-carboxylate compounds and pharmaceutical compositions comprising said compounds. The compounds and compositions provided herein are useful as inhibitors of MAGL. Furthermore, the compounds and compositions as provided herein are useful for the treatment of diseases and disorders benefiting from the inhibition of MAGL.
    Type: Application
    Filed: November 11, 2021
    Publication date: May 19, 2022
    Inventors: John J.M. WIENER, Cheryl A. GRICE, Daniel J. BUZARD, Justin S. CISAR, Olivia Delene WEBER, Amy ALLAN, Nicholas RAFFAELE, Jeanne MOODY, Michael B. SHAGHAFI
  • MAGL inhibitors
    Patent number: 11332453
    Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: May 17, 2022
    Assignee: H. LUNDBECK A/S
    Inventors: Cheryl A. Grice, Daniel J. Buzard, Michael B. Shaghafi
  • MAGL INHIBITORS
    Publication number: 20220135563
    Abstract: Provided herein are spirocyclic and fused bicyclic carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Application
    Filed: June 9, 2021
    Publication date: May 5, 2022
    Inventors: Cheryl A. GRICE, Daniel J. BUZARD, Michael B. SHAGHAFI
  • Pharmaceutical formulations
    Patent number: 11273159
    Abstract: Provided herein are pharmaceutical formulations comprising a monoacylglycerol lipase (MAGL) inhibitor, or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: March 15, 2022
    Assignee: H. LUNDBECK A/S
    Inventors: Cheryl A. Grice, Nicole S. White, Joel P. Zingerman, Hibreniguss Terefe, Isaac Ghebre-Sellassie
  • METHODS OF TREATING DISEASE WITH MAGL INHIBITORS
    Publication number: 20220031676
    Abstract: Provided herein are methods for the treatment of disease with monoacylglycerol lipase (MAGL) inhibitors.
    Type: Application
    Filed: November 26, 2019
    Publication date: February 3, 2022
    Inventors: Channing Rodney BEALS, Dallas JONES, Jason Robert CLAPPER, Gary Paul O'NEILL, Iain Peter FRASER, Jacqueline Lorayne BLANKMAN, John J.M. WIENER, Cheryl A. GRICE
  • MAGL inhibitors
    Patent number: 11214557
    Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: January 4, 2022
    Assignee: H. LUNDBECK A/S
    Inventors: Cheryl A. Grice, Daniel J. Buzard, Michael B. Shaghafi