Patents by Inventor Cheryl A. Janson

Cheryl A. Janson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treating cancer by administering conjugates comprising human IL-18 and substitution mutants thereof
    Patent number: 7736639
    Abstract: Methods of treating cancer in patients in need thereof with human interleukin-18 (IL-18) polypeptides and substitution mutants thereof that are conjugated to water-soluble polymers at specific sites on the human IL-18 protein are disclosed.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: June 15, 2010
    Assignee: GlaxoSmithKline LLC
    Inventors: Narendra Bam, Jacob Bongers, Robert B. Kirkpatrick, Cheryl A. Janson, Zdenka Jonak, Xianyang Qiu, Ping Yeh, Kyung Johanson
  • METHOD OF TREATING CANCER BY ADMINISTERING CONJUGATES COMPRISING HUMAN IL-18 AND SUBSTITUTION MUTANTS THEREOF
    Publication number: 20080206189
    Abstract: Human interleukin-18 (IL-18) polypeptides and substitution mutants thereof were conjugated to water-soluble polymers at specific sites on the human IL-18 protein. These conjugated human IL-18 and substitution mutants thereof retain biological activity. These conjugated cytokines demonstrate enhanced and unexpected biological properties when compared to the corresponding unconjugated cytokines.
    Type: Application
    Filed: December 21, 2007
    Publication date: August 28, 2008
    Inventors: Narendra BAM, Jacob Bongers, Robert B. Kirkpatrick, Cheryl A. Janson, Zdenka Jonak, Xianyang Qiu, Ping Yeh, Kyung Johanson
  • S8 rRNA-binding protein from the small ribosomal subunit of
    Patent number: 7361734
    Abstract: A Staphylococcus aureus S8 native crystalline structure and a Staphylococcus aureus S8 mode of binding with rRNA were identified.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: April 22, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Nestor O. Concha, Richard R. Gontarek, Cheryl A. Janson
  • Conjugates comprising human IL-18 and substitution mutants thereof
    Patent number: 7311902
    Abstract: Human interleukin-18 (IL-18) polypeptides and substitution mutants thereof were conjugated to water-soluble polymers at specific sites on the human IL-18 protein. These conjugated human IL-18 and substitution mutants thereof retain biological activity. These conjugated cytokines demonstrate enhanced and unexpected biological properties when compared to the corresponding unconjugated cytokines.
    Type: Grant
    Filed: April 14, 2004
    Date of Patent: December 25, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: Narendra Bam, Jacob Bongers, Robert B. Kirkpatrick, Cheryl A. Janson, Zdenka Jonak, Xianyang Qiu, Ping Yeh, Kyung Johanson
  • Human IL-18 crystal structure
    Patent number: 7253260
    Abstract: A novel human IL-18 native crystalline structure is identified.
    Type: Grant
    Filed: April 16, 2003
    Date of Patent: August 7, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: Cheryl A. Janson, Nestor O. Concha
  • Undecaprenyl pyrophosphate synthase (upps)enzyme and methods of use
    Publication number: 20070020743
    Abstract: A novel Streptococcus pneumoniae UPPS native crystalline structure and a novel Streptococcus pneumoniae UPPS complex with the substrates FPP and IPP are identified.
    Type: Application
    Filed: December 2, 2002
    Publication date: January 25, 2007
    Inventors: Nestor Concha, Cheryl Janson
  • Murine IL-18 crystal structure
    Publication number: 20060177871
    Abstract: A novel murine IL-18 native crystalline structure is identified.
    Type: Application
    Filed: August 13, 2003
    Publication date: August 10, 2006
    Inventors: Cheryl Janson, Xiayang Qiu, Ward Smith
  • S8 rrna-binding protein from the small ribosomal subunit of staphylococcus aureus
    Publication number: 20050038611
    Abstract: A Staphylococcus aureus S8 native crystalline structure and a Staphylococcus aureus S8 mode of binding with rRNA were identified.
    Type: Application
    Filed: October 15, 2002
    Publication date: February 17, 2005
    Inventors: Nestor Concha, Richard Gontarek, Cheryl Janson
  • Conjugates comprising human IL-18 and substitution mutants thereof
    Publication number: 20050008615
    Abstract: Human interleukin-18 (IL-18) polypeptides and substitution mutants thereof were conjugated to water-soluble polymers at specific sites on the human IL-18 protein. These conjugated human IL-18 and substitution mutants thereof retain biological activity. These conjugated cytokines demonstrate enhanced and unexpected biological properties when compared to the corresponding unconjugated cytokines.
    Type: Application
    Filed: April 14, 2004
    Publication date: January 13, 2005
    Inventors: Narendra Bam, Jacob Bongers, Robert Kirkpatrick, Cheryl Janson, Zdenka Jonak, Xianyang Qiu, Ping Yeh, Kyung Johanson
  • Human IL-18 crystal structure
    Publication number: 20030232032
    Abstract: A novel human IL-18 native crystalline structure is identified.
    Type: Application
    Filed: April 16, 2003
    Publication date: December 18, 2003
    Inventors: Cheryl A. Janson, Nestor O. Concha
  • Methods using the staphylococcus aureus glycyl tRNA synthetase crystalline structure
    Patent number: 6197495
    Abstract: A novel Staphylococcus glycyl tRNA synthetase crystalline structure is identified. Also disclosed are methods of identifying inhibitors of these synthetases and/or active sites, and inhibitors identified by these methods.
    Type: Grant
    Filed: May 10, 1998
    Date of Patent: March 6, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Xiayang Qiu, Neal Frederick Osborne, Christine Mary Richardson, Cheryl A. Janson
  • Methods using the Staphylococcus aureus glycyl tRNA synthetase crystalline structure
    Patent number: 6037117
    Abstract: A novel Staphylococcus glycyl tRNA synthetase crystalline structure is identified. Also disclosed are methods of identifying inhibitors of these synthetases and/or active sites, and inhibitors identified by these methods.
    Type: Grant
    Filed: January 31, 1997
    Date of Patent: March 14, 2000
    Assignees: Smithkline Beecham Corporation, Smithkline Beecham plc
    Inventors: Xiayang Qiu, Neal Frederick Osborne, Christine Mary Richardson, Cheryl A. Janson