Patents by Inventor Cheryl R. Blanchard
Cheryl R. Blanchard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8999000Abstract: A cartilage resurfacing implant is provided for replacing cartilage of an articulating portion of a bone at a skeletal joint having opposed joint surfaces. The cartilage resurfacing implant includes a body having a bearing surface and a bone interface. The bearing surface is able to support articulation with an opposing joint surface.Type: GrantFiled: December 3, 2010Date of Patent: April 7, 2015Assignee: Zimmer Technology, Inc.Inventors: Robert A. Hodorek, Antony J. Lozier, Cheryl R. Blanchard
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Patent number: 8480757Abstract: Implants comprising cartilage and trabecular metal, and methods of making the implants are disclosed. Further disclosed are therapeutic uses of the implants, which include methods of treatment or repair of an chondral or osteochondral defect, such as a chondral or osteochondral injury, lesion or disease. An implant comprises cartilage or chondrocytes and a subchondral base comprising trabecular metal. An implant can comprise a geometric shape such as a cylinder or an anatomical shape such as a condyle, and can be used in conjunction with a positioning structure.Type: GrantFiled: August 28, 2006Date of Patent: July 9, 2013Assignee: Zimmer, Inc.Inventors: Gary Gage, H. Davis Adkisson, IV, Cheryl R. Blanchard
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Publication number: 20110224791Abstract: A cartilage resurfacing implant is provided for replacing cartilage of an articulating portion of a bone at a skeletal joint having opposed joint surfaces. The cartilage resurfacing implant includes a body having a bearing surface and a bone interface. The bearing surface is able to support articulation with an opposing joint surface.Type: ApplicationFiled: December 3, 2010Publication date: September 15, 2011Applicant: Zimmer Technology, Inc.Inventors: Robert A. Hodorek, Antony J. Lozier, Cheryl R. Blanchard
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Publication number: 20090143867Abstract: Implants comprising cartilage and trabecular metal, and methods of making the implants are disclosed. Further disclosed are therapeutic uses of the implants, which include methods of treatment or repair of an chondral or osteochondral defect, such as a chondral or osteochondral injury, lesion or disease. An implant comprises cartilage or chondrocytes and a subchondral base comprising trabecular metal. An implant can comprise a geometric shape such as a cylinder or an anatomical shape such as a condyle, and can be used in conjunction with a positioning structure.Type: ApplicationFiled: August 28, 2006Publication date: June 4, 2009Applicant: ISTO Technologies, Inc.Inventors: Gary Gage, H. Davis Adkisson, IV, Cheryl R. Blanchard
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Patent number: 6849092Abstract: A keratin hydrogel-filled implantable prosthetic device. One device is a breast implant for augmenting or reconstructing a human breast including an envelope containing a keratin hydrogel. One keratin hydrogel is formed from a solid precursor which forms a keratin hydrogel upon addition of water. One source of keratin is human hair. In one method, an envelope suitable for implantation and a solid keratin hydrogel precursor are provided. The solid can be in fibrous or powder form. The solid precursor can be inserted into the envelope interior. A small incision near the breast can be made and the envelope inserted into the incision. After insertion, water can be injected into the envelope interior, preferably through the incision and through a self-sealing port in the envelope. In one method, the implant is provided as a kit, with the envelope and keratin hydrogel provided. The hydrogel can be injected into the envelope either before or after insertion into the breast area.Type: GrantFiled: March 8, 2001Date of Patent: February 1, 2005Assignee: Keraplast Technologies, Ltd.Inventors: Mark E. Van Dyke, Cheryl R. Blanchard, Scott F. Timmons, Arlene J. Siller-Jackson, Robert A. Smith
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Publication number: 20040134248Abstract: A hydratable oxidized keratin composition comprising one or more metal ion species capable of absorbing water to form a hydrogel. The keratin material is useful as a soil amendment providing organic and inorganic nutrients. The keratin material is also useful as a nutrient source in the bioremediation of toxic contaminants soils and liquids.Type: ApplicationFiled: November 17, 2003Publication date: July 15, 2004Applicants: Southwest Research Institute, Keraplast Technologies, Ltd.Inventors: Robert Allen Smith, Scott F. Timmons, Mark E. Van Dyke, Cheryl R. Blanchard, Arlene J. Siller-Jackson
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Publication number: 20040082717Abstract: Materials comprising proteinaceous prepolymers comprising at least one first reactive group reacted with one or more reactive groups on synthetic prepolymers, and methods of making and using same.Type: ApplicationFiled: June 24, 2003Publication date: April 29, 2004Applicants: Southwest Research Institute, Keraplast Technologies, Ltd.Inventors: Mark E. Van Dyke, Cheryl R. Blanchard, Robert A. Smith
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Publication number: 20040076599Abstract: A hydratable, highly absorbent keratin solid fiber or powder capable of absorbing a large weight excess of water may be produced by partially oxidizing hair keratin disulfide bonds to sulfonic acid residues and reacting the sulfonic acid residues with a cation. The neutralized suspension can be filtered, washed, and dried, leaving keratin solid which can be shredded into fibers and further ground into powder. Addition of water to the solid produces a hydrogel. The powder or hydrogel may be useful as an absorbent material, as a therapeutic for skin, or as an excipient. The keratin materials can be incorporated into nonwoven films. The hydrogel can be used as a biocompatible viscoelastic filler for implant applications. Another use for the absorbent keratin and keratin hydrogel is as an excipient in pharmaceutical and cosmetic applications.Type: ApplicationFiled: April 8, 2003Publication date: April 22, 2004Applicants: Southwest Research Institute, Keraplast Technologies, Ltd.Inventors: Arlene J. Siller-Jackson, Mark E. Van Dyke, Scott F. Timmons, Cheryl R. Blanchard, Robert A. Smith
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Patent number: 6649740Abstract: A hydratable oxidized keratin composition comprising one or more metal ion species capable of absorbing water to form a hydrogel. The keratin material is useful as a soil amendment providing organic and inorganic nutrients. The keratin material is also useful as a nutrient source in the bioremediation of toxic contaminants soils and liquids.Type: GrantFiled: March 1, 2000Date of Patent: November 18, 2003Assignee: Keraplast Technologies, Ltd.Inventors: Robert Allen Smith, Scott F. Timmons, Mark E. Van Dyke, Cheryl R. Blanchard, Arlene J. Siller-Jackson
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Patent number: 6544548Abstract: A hydratable, highly absorbent keratin solid fiber or powder capable of absorbing a large weight excess of water may be produced by partially oxidizing hair keratin disulfide bonds to sulfonic acid residues and reacting the sulfonic acid residues with a cation. The neutralized suspension can be filtered, washed, and dried, leaving keratin solid which can be shredded into fibers and further ground into powder. Addition of water to the solid produces a hydrogel. The powder or hydrogel may be useful as an absorbent material, as a therapeutic for skin, or as an excipient. The keratin materials can be incorporated into nonwoven films. The hydrogel can be used as a biocompatible viscoelastic filler for implant applications. Another use for the absorbent keratin and keratin hydrogel is as an excipient in pharmaceutical and cosmetic applications.Type: GrantFiled: August 14, 2000Date of Patent: April 8, 2003Assignee: Keraplast Technologies, Ltd.Inventors: Arlene J. Siller-Jackson, Mark E. Van Dyke, Scott F. Timmons, Cheryl R. Blanchard, Robert A. Smith
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Publication number: 20030035820Abstract: Methods for producing thin keratin films, sheets, and bulk materials, and products formed using these methods. One method includes providing hair, reducing the hair such that the disulfide linkages are broken and free cysteine thiol groups formed, separating out a more soluble keratin fraction in solution, forming a thin layer from the more soluble fraction, and air drying the keratin fraction in the presence of oxygen, thereby forming new disulfide bonds imparting strength to the resulting thin keratin film. One method includes reducing hair by heating the hair under nitrogen in an ammonium hydroxide and ammonium thioglycolate solution followed by centrifuging and collecting the supernatant containing the more soluble keratin fraction. The more soluble keratin in this method is precipitated using HCI, removed, and resuspended in ammonium hydroxide. The keratin solution thus formed is poured onto a flat surface and allowed to air dry into a thin keratin film.Type: ApplicationFiled: August 13, 2002Publication date: February 20, 2003Applicant: Southwest Research Institute and Keraplast Technologies, Ltd.Inventors: Scott F. Timmons, Cheryl R. Blanchard, Robert A. Smith
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Patent number: 6461628Abstract: A hydratable, highly absorbent keratin solid fiber or powder capable of absorbing a large weight excess of water may be produced by partially oxidizing hair keratin disulfide bonds to sulfonic acid residues and reacting the sulfonic acid residues with a cation. The neutralized suspension can be filtered, washed, and dried, leaving keratin solid which can be shredded into fibers and further ground into powder. Addition of water to the solid produces a hydrogel. The powder or hydrogel may be useful as an absorbent material, as a therapeutic for skin, or as an excipient. The keratin materials can be incorporated into nonwoven films. The hydrogel may be used as biocompatible viscoelastic filler for implant applications. Both the hydrogel and nonwoven materials are also suitable for use as tissue engineering scaffolds.Type: GrantFiled: June 5, 2000Date of Patent: October 8, 2002Assignee: Keraplast Technologies, Ltd.Inventors: Cheryl R. Blanchard, Mark E. Van Dyke, Scott F. Timmons, Arlene J. Siller-Jackson, Robert A. Smith
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Patent number: 6432435Abstract: Methods for producing thin keratin films, sheets, and bulk materials, and products formed using these methods. One method includes providing hair, reducing the hair such that the disulfide linkages are broken and free cysteine thiol groups formed, separating out a more soluble keratin fraction in solution, forming a thin layer from the more soluble fraction, and air drying the keratin fraction in the presence of oxygen, thereby forming new disulfide bonds imparting strength to the resulting thin keratin film. One method includes reducing hair by heating the hair under nitrogen in an ammonium hydroxide and ammonium thioglycolate solution followed by centrifuging and collecting the supernatant containing the more soluble keratin fraction. The more soluble keratin in this method is precipitated using HCI, removed, and resuspended in ammonium hydroxide. The keratin solution thus formed is poured onto a flat surface and allowed to air dry into a thin keratin film.Type: GrantFiled: October 10, 2000Date of Patent: August 13, 2002Assignee: Keraplast Technologies, Ltd.Inventors: Scott F. Timmons, Cheryl R. Blanchard, Robert A. Smith
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Patent number: 6379690Abstract: A keratin hydrogel which can be used as a wound dressing and cell scaffolding. The keratin hydrogel is formed from clean, washed hair by partially oxidizing a significant percentage of disulfide linkages to form cysteic acid groups, while some disulfide linkages remain intact. The partially oxidized hair is treated with a reducing agent, thereby reducing most of the remaining disulfide linkages to cysteine-thioglycollate disulfide and cysteine groups. A soluble fraction of hair is collected and oxidized, such that the reduced sulfur groups are allowed to reform disulfide linkages, thereby binding the keratin together. The cysteic acid groups remain, providing hydrophilic sites within the hydrogel. A higher degree of partial oxidation results in a greater abundance of hydrophilic cysteic acid groups in the hydrogel.Type: GrantFiled: December 12, 2000Date of Patent: April 30, 2002Assignee: Keraplast Technologies, Ltd.Inventors: Cheryl R. Blanchard, Scott F. Timmons, Robert A. Smith
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Patent number: 6371984Abstract: A keratin hydrogel-filled implantable prosthetic device. One device is a breast implant for augmenting or reconstructing a human breast including an envelope containing a keratin hydrogel. One keratin hydrogel is formed from a solid precursor which forms a keratin hydrogel upon addition of water. One source of keratin is human hair. In one method, an envelope suitable for implantation and a solid keratin hydrogel precursor are provided. The solid can be in fibrous or powder form. The solid precursor can be inserted into the envelope interior. A small incision near the breast can be made and the envelope inserted into the incision. After insertion, water can be injected into the envelope interior, preferably through the incision and through a self-sealing port in the envelope. In one method, the implant is provided as a kit, with the envelope and keratin hydrogel provided. The hydrogel can be injected into the envelope either before or after insertion into the breast area.Type: GrantFiled: September 13, 1999Date of Patent: April 16, 2002Assignee: Keraplast Technologies, Ltd.Inventors: Mark E. Van Dyke, Cheryl R. Blanchard, Scott F. Timmons, Arlene J. Siller-Jackson, Robert A. Smith
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Publication number: 20010047082Abstract: A peptide derived from keratin, which can be used as a wound-healing agent. In one method for making the peptide, a keratin source such as human hair is washed, dried, and treated with an oxidizing agent such as peracetic acid for a time and temperature sufficient to swell the keratin and oxidize some of the disulfide bonds to form sulfonic acid groups. The oxidation is believed to form a series of water-soluble peptides. The oxidized hair can be filtered, and the filtrate collected and concentrated under vacuum distillation to a viscous syrup, which can be neutralized with base. The concentrate can be mixed with an excess of a water-miscible organic solvent such as methanol, and the precipitate collected and dried to form the wound-healing agent. The wound-healing agent is believed to include peptides having a molecular weight centered around 850 daltons and having at least one ionizeable group such as sulfonic acid.Type: ApplicationFiled: July 2, 2001Publication date: November 29, 2001Inventors: Mark E. Van Dyke, Cheryl R. Blanchard, Scott F. Timmons, Arlene J. Siller-Jackson, Robert A. Smith
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Patent number: 6316598Abstract: A hydratable, highly absorbent keratin solid fiber or powder capable of absorbing a large weight excess of water may be produced by partially oxidizing hair keratin disulfide bonds to sulfonic acid residues and reacting the sulfonic acid residues with a cation. The neutralized suspension can be filtered, washed, and dried, leaving keratin solid which can be shredded into fibers and further ground into powder. Addition of water to the solid produces a hydrogel. The powder or hydrogel may be useful as an absorbent material, as a therapeutic for skin, or as an excipient. Another use for the hydrogel is as a biocompatible viscoelastic filler for implant applications.Type: GrantFiled: September 13, 1999Date of Patent: November 13, 2001Assignee: Keraplast Technologies, Ltd.Inventors: Mark E. Van Dyke, Cheryl R. Blanchard, Scott F. Timmons, Arlene J. Siller-Jackson, Robert A. Smith
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Publication number: 20010032019Abstract: A keratin hydrogel-filled implantable prosthetic device. One device is a breast implant for augmenting or reconstructing a human breast including an envelope containing a keratin hydrogel. One keratin hydrogel is formed from a solid precursor which forms a keratin hydrogel upon addition of water. One source of keratin is human hair. In one method, an envelope suitable for implantation and a solid keratin hydrogel precursor are provided. The solid can be in fibrous or powder form. The solid precursor can be inserted into the envelope interior. A small incision near the breast can be made and the envelope inserted into the incision. After insertion, water can be injected into the envelope interior, preferably through the incision and through a self-sealing port in the envelope. In one method, the implant is provided as a kit, with the envelope and keratin hydrogel provided. The hydrogel can be injected into the envelope either before or after insertion into the breast area.Type: ApplicationFiled: March 8, 2001Publication date: October 18, 2001Applicant: Southwest Research Institute and Keraplast technolInventors: Mark E. Van Dyke, Cheryl R. Blanchard, Scott F. Timmons, Arlene J. Siller-Jackson, Robert A. Smith
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Patent number: 6274163Abstract: A keratinous wound healing material, preferably derived from the hair of the patient or a compatible donor. Keratin powder can be derived from hair using processing steps including cleaning, suspending in a liquid carrier, homogenizing and removing the liquid. The keratinous material may be applied to the wound in powder form. The keratin can also be applied in sheet form. The keratinous material can be bound with polymeric binder and formed into a sheet by pouring the polymer/binder solution into a mold and flashing off the solvent.Type: GrantFiled: April 8, 1998Date of Patent: August 14, 2001Assignee: Keraplast Technologies, Ltd.Inventors: Cheryl R. Blanchard, Robert A. Smith, Arlene J. Siller-Jackson
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Patent number: 6274155Abstract: A hydratable, highly absorbent keratin solid fiber or powder capable of absorbing a large weight excess of water may be produced by partially oxidizing hair keratin disulfide bonds to sulfonic acid residues and reacting the sulfonic acid residues with a cation. The neutralized suspension can be filtered, washed, and dried, leaving keratin solid which can be shredded into fibers and further ground into powder. Addition of water to the solid produces a hydrogel. The powder or hydrogel may be useful as an absorbent material, as a therapeutic for skin, or as an excipient. The keratin materials can be incorporated into nonwoven films. Another use for the hydrogel is as a biocompatible viscoelastic filler for implant applications.Type: GrantFiled: February 25, 2000Date of Patent: August 14, 2001Assignee: Keraplast Technologies, Ltd.Inventors: Mark E. Van Dyke, Scott F. Timmons, Cheryl R. Blanchard, Arlene J. Siller-Jackson, Robert A. Smith