Abstract: Radiolabeled liposomes can be used in the treatment of cancer. These local therapies can be used to treat cancers including, but not limited to, lung cancer, breast cancer, colorectal cancer, prostate cancer, skin cancer, stomach cancer, bladder cancer, liver cancer, leukemia, lymphoma, ovarian cancer, pancreatic cancer, hepatocellular carcinoma, melanoma, sarcoma, head and neck cancer, glioma, glioblastoma, medulloblastoma, ependymoma, diffuse intrinsic pontine glioma, leptomeningeal metastases, and pediatric high-grade glioma.

Abstract: A method for acoustic tomography within a patient may include generating a focused ultrasonic signal using a transducer is provided; the ultrasonic signal forming a path within the patient. The method includes directing the ultrasonic signal on a spot within the patient; scanning the spot in a predetermined pattern about a volume within the patient; receiving an ultrasonic echo in the transducer; converting the ultrasonic echo into a voltage; selecting a frequency band from the voltage; amplifying the voltage in the selected frequency band with a processing circuit; and generating an image of the volume within the patient structure utilizing the amplified voltage. A method for recanalization of a blood vessel including the above acoustic tomography steps is also provided.

Abstract: The present disclosure provides a method of fabricating an ultrasound transducer. A substrate having a first side and a second side opposite the first side is provided. A bottom electrode is formed over the first side of the substrate. A piezoelectric element is formed over the bottom electrode. The piezoelectric element has a chamfered sidewall. A top electrode is formed over the piezoelectric element. A step metal element is formed over a portion of the top electrode proximate to the chamfered sidewall of the piezoelectric element.

Abstract: A method for acoustic tomography within a patient may include generating a focused ultrasonic signal using a transducer is provided; the ultrasonic signal forming a path within the patient. The method includes directing the ultrasonic signal on a spot within the patient; scanning the spot in a predetermined pattern about a volume within the patient; receiving an ultrasonic echo in the transducer; converting the ultrasonic echo into a voltage; selecting a frequency band from the voltage; amplifying the voltage in the selected frequency band with a processing circuit; and generating an image of the volume within the patient structure utilizing the amplified voltage. A method for recanalization of a blood vessel including the above acoustic tomography steps is also provided.

Abstract: A method for acoustic tomography within a patient may include generating a focused ultrasonic signal using a transducer is provided; the ultrasonic signal forming a path within the patient. The method includes directing the ultrasonic signal on a spot within the patient; scanning the spot in a predetermined pattern about a volume within the patient; receiving an ultrasonic echo in the transducer; converting the ultrasonic echo into a voltage; selecting a frequency band from the voltage; amplifying the voltage in the selected frequency band with a processing circuit; and generating an image of the volume within the patient structure utilizing the amplified voltage. A method for recanalization of a blood vessel including the above acoustic tomography steps is also provided.

Abstract: The present disclosure provides a method of fabricating an ultrasound transducer. A substrate having a first side and a second side opposite the first side is provided. A bottom electrode is formed over the first side of the substrate. A piezoelectric element is formed over the bottom electrode. The piezoelectric element has a chamfered sidewall. A top electrode is formed over the piezoelectric element. A step metal element is formed over a portion of the top electrode proximate to the chamfered sidewall of the piezoelectric element.

Abstract: The present disclosure provides a method of fabricating an ultrasound transducer. A substrate having a first side and a second side opposite the first side is provided. A bottom electrode is formed over the first side of the substrate. A piezoelectric element is formed over the bottom electrode. The piezoelectric element has a chamfered sidewall. A top electrode is formed over the piezoelectric element. A step metal element is formed over a portion of the top electrode proximate to the chamfered sidewall of the piezoelectric element.

Abstract: The present disclosure provides a method of fabricating an ultrasound transducer. A substrate having a first side and a second side opposite the first side is provided. A bottom electrode is formed over the first side of the substrate. A piezoelectric element is formed over the bottom electrode. The piezoelectric element has a chamfered sidewall. A top electrode is formed over the piezoelectric element. A step metal element is formed over a portion of the top electrode proximate to the chamfered sidewall of the piezoelectric element.

Abstract: A method of fabricating an ultrasound transducer includes providing a substrate having a first side and a second side opposite the first side. A bottom electrode is formed over the first side of the substrate. A piezoelectric element is formed over the bottom electrode. The piezoelectric element has a chamfered sidewall. A top electrode is formed over the piezoelectric element. A step metal element is formed over a portion of the top electrode proximate to the chamfered sidewall of the piezoelectric element.

Abstract: The present disclosure provides a transducer assembly. The transducer assembly includes a flex circuit. The transducer assembly also includes a first substrate that includes a piezoelectric micro-machined ultrasonic transducer (PMUT). The transducer assembly further includes a second substrate that includes an Integrated Circuit (IC) device. At least one of the first substrate and the second substrate is bonded to the flex circuit through wire bonding or through flip-chip.

Abstract: A method for acoustic tomography within a patient may include generating a focused ultrasonic signal using a transducer is provided; the ultrasonic signal forming a path within the patient. The method includes directing the ultrasonic signal on a spot within the patient; scanning the spot in a predetermined pattern about a volume within the patient; receiving an ultrasonic echo in the transducer; converting the ultrasonic echo into a voltage; selecting a frequency band from the voltage; amplifying the voltage in the selected frequency band with a processing circuit; and generating an image of the volume within the patient structure utilizing the amplified voltage. A method for recanalization of a blood vessel including the above acoustic tomography steps is also provided.

Abstract: The present disclosure provides a method of fabricating an ultrasound transducer. A substrate having a first side and a second side opposite the first side is provided. A bottom electrode is formed over the first side of the substrate. A piezoelectric element is formed over the bottom electrode. The piezoelectric element has a chamfered sidewall. A top electrode is formed over the piezoelectric element. A step metal element is formed over a portion of the top electrode proximate to the chamfered sidewall of the piezoelectric element.

Abstract: The present disclosure provides a method of fabricating an ultrasound transducer. A substrate having a first side and a second side opposite the first side is provided. A bottom electrode is formed over the first side of the substrate. A piezoelectric element is formed over the bottom electrode. The piezoelectric element has a chamfered sidewall. A top electrode is formed over the piezoelectric element. A step metal element is formed over a portion of the top electrode proximate to the chamfered sidewall of the piezoelectric element.

Abstract: The present disclosure provides a method of singulating a plurality of miniature ultrasound transducers from a wafer. The method includes receiving a wafer on which a plurality of miniature ultrasound transducers is formed. The miniature ultrasound transducers each include a transducer membrane containing a piezoelectric material. The method includes etching, from a front side of the wafer, a plurality of trenches into the wafer. Each trench at least partially encircles a respective one of the miniature ultrasound transducers in a top view. Each trench includes an approximately rounded segment. The method includes thinning the wafer from a back side opposite the front side. The thinning the wafer is performed such that the trenches are open to the back side. The method includes performing a dicing process to the wafer to separate the miniature ultrasound transducers from one another. The dicing process is performed without making crossing cuts in the wafer.

Abstract: The present disclosure provides a method of singulating a plurality of miniature ultrasound transducers from a wafer. The method includes receiving a wafer on which a plurality of miniature ultrasound transducers is formed. The miniature ultrasound transducers each include a transducer membrane containing a piezoelectric material. The method includes etching, from a front side of the wafer, a plurality of trenches into the wafer. Each trench at least partially encircles a respective one of the miniature ultrasound transducers in a top view. Each trench includes an approximately rounded segment. The method includes thinning the wafer from a back side opposite the front side. The thinning the wafer is performed such that the trenches are open to the back side. The method includes performing a dicing process to the wafer to separate the miniature ultrasound transducers from one another. The dicing process is performed without making crossing cuts in the wafer.

Abstract: A balloon catheter having a balloon with a reduced slippage lubricious coating, and a method of performing a medical procedure such as a balloon dilatation procedure in a patient's blood vessel. The second coating (i.e., the balloon coating) is lubricious to facilitate movement of the catheter in the patient's body lumen, yet has sufficiently low lubricity such that the slippage of the inflated balloon from a desired site within the blood vessel is reduced compared to a balloon coated with the first lubricious coating.

Abstract: A balloon catheter having a balloon with a reduced slippage lubricious coating, and a method of performing a medical procedure such as a balloon dilatation procedure in a patient's blood vessel. The second coating (i.e., the balloon coating) is lubricious to facilitate movement of the catheter in the patient's body lumen, yet has sufficiently low lubricity such that the slippage of the inflated balloon from a desired site within the blood vessel is reduced compared to a balloon coated with the first lubricious coating.

Abstract: A balloon catheter having a balloon with a reduced slippage lubricious coating, and a method of performing a medical procedure such as a balloon dilatation procedure in a patient's blood vessel. The second coating (i.e., the balloon coating) is lubricious to facilitate movement of the catheter in the patient's body lumen, yet has sufficiently low lubricity such that the slippage of the inflated balloon from a desired site within the blood vessel is reduced compared to a balloon coated with the first lubricious coating.

Abstract: A balloon catheter having a balloon with a reduced slippage lubricious coating, and a method of performing a medical procedure such as a balloon dilatation procedure in a patient's blood vessel. The second coating (i.e., the balloon coating) is lubricious to facilitate movement of the catheter in the patient's body lumen, yet has sufficiently low lubricity such that the slippage of the inflated balloon from a desired site within the blood vessel is reduced compared to a balloon coated with the first lubricious coating.

Abstract: A balloon catheter having a balloon with a reduced slippage lubricious coating, and a method of performing a medical procedure such as a balloon dilatation procedure in a patient's blood vessel. The second coating (i.e., the balloon coating) is lubricious to facilitate movement of the catheter in the patient's body lumen, yet has sufficiently low lubricity such that the slippage of the inflated balloon from a desired site within the blood vessel is reduced compared to a balloon coated with the first lubricious coating.