Abstract: A medical imaging system that uses a plurality of time windows in signal integration is provided. The medical imaging system includes a gamma-ray detector, a set of digital readout channels, and a window generator. The gamma-ray detector includes a crystal array and a photosensor array. The photosensor array generates electrical signals in response to receiving incident scintillation light emitted from the crystal array in response to a gamma-ray interaction occurring in the crystal array. The set of digital readout channels acquires the electrical signals and generates a set of digital signals indicating information relating to the gamma-ray interaction. Each channel of the set of digital readout channels includes a charge integrator and an analog-to-digital converter. The window generator generates a plurality of time windows and a single analog-to-digital conversion (ADC) start signal.