Patents by Inventor Cheryl Stacy
Cheryl Stacy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8541655Abstract: Compositions and methods for controlling plant pests are disclosed. In particular, transgenic maize plants comprising nucleic acid molecules encoding modified Cry3A toxins having increased toxicity to western corn rootworm are provided. Such modified Cry3A toxins, into which a non-naturally occurring protease recognition site is inserted, are expressed at levels in transgenic plants to inhibit insect feeding damage and cause insect mortality.Type: GrantFiled: June 18, 2012Date of Patent: September 24, 2013Assignee: Syngenta Participations AGInventors: Eric Chen, Cheryl Stacy
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Patent number: 8309516Abstract: Compositions and methods for controlling plant pests are disclosed. In particular, novel engineered hybrid insecticidal proteins (eHIPs) having toxicity to at least corn rootworm are provided. By fusing unique combinations of complete or partial variable regions and conserved blocks of at least two different Bacillus thuringiensis (Bt) Cry proteins or a modified Cry proteins an eHIP having activity against corn rootworm is designed. Nucleic acid molecules encoding the novel eHIPs are also provided. Methods of making the eHIPs and methods of using the eHIPs and nucleic acids encoding the eHIPs of the invention, for example in transgenic plants to confer protection from insect damage are also disclosed.Type: GrantFiled: March 26, 2008Date of Patent: November 13, 2012Assignee: Syngenta Participations AGInventors: Hope Hart, Jeng S. Chen, Cheryl Stacy, Frederick Walters
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Publication number: 20120260372Abstract: Compositions and methods for controlling plant pests are disclosed. In particular, transgenic maize plants comprising nucleic acid molecules encoding modified Cry3A toxins having increased toxicity to western corn rootworm are provided. Such modified Cry3A toxins, into which a non-naturally occurring protease recognition site is inserted, are expressed at levels in transgenic plants to inhibit insect feeding damage and cause insect mortality.Type: ApplicationFiled: June 18, 2012Publication date: October 11, 2012Applicant: SYNGENTA PARTICIPATIONS AGInventors: Eric CHEN, Cheryl Stacy
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Patent number: 8216806Abstract: Methods for making a modified Cry3A toxin are disclosed. Such methods include the insertion of a protease recognition site that is recognized by a gut protease of a target insect, such as corn rootworm, into at least one position of a Cry3A toxin so that a modified Cry3A toxin is thus designed. The coding sequence of the modified Cry3A toxin may be transformed into a host cell and the host cell grown under conditions that allow the host cell to produce the modified Cry3A toxin. The host cell may be a plant cell and the plant may be comprised in a transgenic plant. Thus, the transgenic plant may be used to produce the modified Cry3A toxin.Type: GrantFiled: July 25, 2011Date of Patent: July 10, 2012Assignee: Syngenta Participations AGInventors: Eric Chen, Cheryl Stacy
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Publication number: 20110289627Abstract: Methods for making a modified Cry3A toxin are disclosed. Such methods include the insertion of a protease recognition site that is recognized by a gut protease of a target insect, such as corn rootworm, into at least one position of a Cry3A toxin so that a modified Cry3A toxin is thus designed. The coding sequence of the modified Cry3A toxin may be transformed into a host cell and the host cell grown under conditions that allow the host cell to produce the modified Cry3A toxin. The host cell may be a plant cell and the plant may be comprised in a transgenic plant. Thus, the transgenic plant may be used to produce the modified Cry3A toxin.Type: ApplicationFiled: July 25, 2011Publication date: November 24, 2011Inventors: Eric Chen, Cheryl Stacy
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Publication number: 20110288272Abstract: Methods for making a modified Cry3A toxin are disclosed. Such methods include the insertion of a protease recognition site that is recognized by a gut protease of a target insect, such as corn rootworm, into at least one position of a Cry3A toxin so that a modified Cry3A toxin is thus designed. The coding sequence of the modified Cry3A toxin may be transformed into a host cell and the host cell grown under conditions that allow the host cell to produce the modified Cry3A toxin. The host cell may be a plant cell and the plant may be comprised in a transgenic plant. Thus, the transgenic plant may be used to produce the modified Cry3A toxin.Type: ApplicationFiled: July 25, 2011Publication date: November 24, 2011Inventors: Eric Chen, Cheryl Stacy
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Publication number: 20100017914Abstract: Compositions and methods for controlling plant pests are disclosed. In particular, novel engineered hybrid insecticidal proteins (eHIPs) having toxicity to at least corn rootworm are provided. By fusing unique combinations of complete or partial variable regions and conserved blocks of at least two different Bacillus thuringiensis (Bt) Cry proteins or a modified Cry proteins an eHIP having activity against corn rootworm is designed. Nucleic acid molecules encoding the novel eHIPs are also provided. Methods of making the eHIPs and methods of using the eHIPs and nucleic acids encoding the eHIPs of the invention, for example in transgenic plants to confer protection from insect damage are also disclosed.Type: ApplicationFiled: March 26, 2008Publication date: January 21, 2010Applicant: SYNGENTA PARTICIPATIONS AGInventors: Hope Hart, Jeng S. Chen, Cheryl Stacy, Frederick Walters
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Publication number: 20090265809Abstract: Methods for making a modified Cry3A toxin are disclosed. Such methods include the insertion of a protease recognition site that is recognized by a gut protease of a target insect, such as corn rootworm, into at least one position of a Cry3A toxin so that a modified Cry3A toxin is thus designed. The coding sequence of the modified Cry3A toxin may be transformed into a host cell and the host cell grown under conditions that allow the host cell to produce the modified Cry3A toxin. The host cell may be a plant cell and the plant may be comprised in a transgenic plant. Thus, the transgenic plant may be used to produce the modified Cry3A toxin.Type: ApplicationFiled: June 22, 2009Publication date: October 22, 2009Applicant: SYNGENTA PARTICIPATIONS AGInventors: Eric Chen, Cheryl Stacy
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Patent number: 7569363Abstract: Methods for making a modified Cry3A toxin are disclosed. Such methods include the insertion of a protease recognition site that is recognized by a gut protease of a target insect, such as corn rootworm, into at least one position of a Cry3A toxin so that a modified Cry3A toxin is thus designed. The coding sequence of the modified Cry3A toxin may be transformed into a host cell and the host cell grown under conditions that allow the host cell to produce the modified Cry3A toxin. The host cell may be a plant cell and the plant may be comprised in a transgenic plant. Thus, the transgenic plant may be used to produce the modified Cry3A toxin.Type: GrantFiled: August 6, 2007Date of Patent: August 4, 2009Assignee: Syngenta Participations AGInventors: Eric Chen, Cheryl Stacy
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Publication number: 20080182796Abstract: Compositions and methods for controlling plant pests are disclosed. In particular, novel nucleic acid sequences encoding modified Cry3A toxins having increased toxicity to corn rootworm are provided. By inserting a protease recognition site that is recognized by a gut protease of a target insect in at least one position of a Cry3A toxin a modified Cry3A toxin having significantly greater toxicity, particularly to western and northern corn rootworm is designed.Type: ApplicationFiled: April 30, 2007Publication date: July 31, 2008Inventors: Jeng S. Chen, Cheryl Stacy, Frederick Walters
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Publication number: 20080044907Abstract: Methods for making a modified Cry3A toxin are disclosed. Such methods include the insertion of a protease recognition site that is recognized by a gut protease of a target insect, such as corn rootworm, into at least one position of a Cry3A toxin so that a modified Cry3A toxin is thus designed. The coding sequence of the modified Cry3A toxin may be transformed into a host cell and the host cell grown under conditions that allow the host cell to produce the modified Cry3A toxin. The host cell may be a plant cell and the plant may be comprised in a transgenic plant. Thus, the transgenic plant may be used to produce the modified Cry3A toxin.Type: ApplicationFiled: August 6, 2007Publication date: February 21, 2008Applicant: SYNGENTA PARTICIPATIONS AGInventors: Eric Chen, Cheryl Stacy
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Patent number: 7276583Abstract: Compositions and methods for controlling plant pests are disclosed. In particular, novel nucleic acid sequences encoding modified Cry3A toxins having increased toxicity to corn rootworm are provided. By inserting a protease recognition site, such as cathepsin G, that is recognized by a gut protease of a target insect in at least one position of a Cry3A toxin a modified Cry3A toxin having significantly greater toxicity, particularly to western and northern corn rootworm is designed.Type: GrantFiled: December 5, 2005Date of Patent: October 2, 2007Assignee: Syngenta Participations AGInventors: Eric Chen, Cheryl Stacy
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Patent number: 7230167Abstract: Compositions and methods for controlling plant pests are disclosed. In particular, novel nucleic acid sequences encoding modified Cry3A toxins having increased toxicity to corn rootworm are provided. By inserting a protease recognition site such as cathepsin G, that is recognized by a gut protease of a target insect in at least one position of a Cry3A toxin a modified Cry3A toxin having significantly greater toxicity, particularly to western and northern corn rootworm is designed.Type: GrantFiled: February 9, 2002Date of Patent: June 12, 2007Assignee: Syngenta Participations AGInventors: Eric Chen, Cheryl Stacy
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Publication number: 20060085870Abstract: Compositions and methods for controlling plant pests are disclosed. In particular, novel nucleic acid sequences encoding modified Cry3A toxins having increased toxicity to corn rootworm are provided. By inserting a protease recognition site, such as cathepsin G, that is recognized by a gut protease of a target insect in at least one position of a Cry3A toxin a modified Cry3A toxin having significantly greater toxicity, particularly to western and northern corn rootworm is designed.Type: ApplicationFiled: December 5, 2005Publication date: April 20, 2006Applicant: Syngenta Participations AGInventors: Eric Chen, Cheryl Stacy
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Patent number: 7030295Abstract: Compositions and methods for controlling plant pests are disclosed. In particular, novel nucleic acid sequences encoding modified Cry3A toxins having increased toxicity to corn rootworm are provided. By inserting a protease recognition site, such as cathepsin G, that is recognized by a gut protease of a target insect in at least one position of a Cry3A toxin a modified Cry3A toxin having significantly greater toxicity, particularly to western and northern corn rootworm is designed.Type: GrantFiled: August 27, 2002Date of Patent: April 18, 2006Assignee: Syngenta Participations AGInventors: Eric Chen, Cheryl Stacy
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Publication number: 20040199939Abstract: Compositions and methods for controlling plant pests are disclosed. In particular, novel nucleic acid sequences encoding modified Cry3A toxins having increased toxicity to corn rootworm are provided. By inserting a protease recognition site such as cathepsin G, that is recognized by a gut protease of a target insect in at least one position of a Cry3A toxin a modified Cry3A toxin having significantly greater toxicity, particularly to western and northern corn rootworm is designed.Type: ApplicationFiled: February 25, 2004Publication date: October 7, 2004Inventors: Eric Chen, Cheryl Stacy
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Publication number: 20030120054Abstract: Compositions and methods for controlling plant pests are disclosed. In particular, novel nucleic acid sequences encoding modified Cry3A toxins having increased toxicity to corn rootworm are provided. By inserting a protease recognition site, such as cathepsin G, that is recognized by a gut protease of a target insect in at least one position of a Cry3A toxin a modified Cry3A toxin having significantly greater toxicity, particularly to western and northern corn rootworm is designed.Type: ApplicationFiled: August 27, 2002Publication date: June 26, 2003Inventors: Eric Chen, Cheryl Stacy