Patents by Inventor Chester A. Metcalf

Chester A. Metcalf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic heteroaryl compounds
    Publication number: 20070191376
    Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
    Type: Application
    Filed: December 22, 2006
    Publication date: August 16, 2007
    Inventors: Dong Zou, Wei-Sheng Huang, R. Thomas, Jan Romero, Jiwei Qi, Yihan Wang, Xiaotian Zhu, William Shakespeare, Rajeswari Sundaramoorthi, Chester Metcalf,, David Dalgarno, Tomi Sawyer
  • Phosphorus-containing compounds & uses thereof
    Publication number: 20070190106
    Abstract: This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA- in which: A is absent or is —O—, —S— or —NR2—; Q is absent or (if A is —O—, —S— or —NR2—) Q may be —V—, —OV—, —SV—, or —NR2V—, where V is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, such that J is linked to the cyclohexyl ring directly, through A or through VA, OVA, SVA or NR2VA; K is O or S; each occurrence of Y is independently —O—, —S—, —NR2—, or a bond linking a R5 moiety to P; each occurrence of R2 and R5 is independently an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, or H; and each occurrence of R6 is independently —PK(YR5)(YR5), —SO2(YR5) or —C(O)(YR5); so long as any R2, or R5 moiety linked directly to P is not H; wherein two R2, R5 and/or R6 moieties may be chemically linked to one another to form a ring; each occurrence of G is independently —O—, —S—, —NR2— or (M)x; each occurrence of M is independently a substituted or unsubstituted methylene moiety, and any M-M? moie
    Type: Application
    Filed: January 5, 2007
    Publication date: August 16, 2007
    Inventors: David Berstein, Leonard Rozamus, Yihan Wang, Chester Metcalf
  • Phosphorus-containing compounds and uses thereof
    Patent number: 7186826
    Abstract: This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA— in which: A is absent or is —O—, —S— or —NR2—; Q is absent or (if A is —O—, —S— or —NR2—) Q may be —V—, —OV—, —SV—, or —NR2V—, where V is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, such that J is linked to the cyclohexyl ring directly, through A or through VA, OVA, SVA or NR2VA; K is O or S; each occurrence of Y is independently —O—, —S—, —NR2—, or a bond linking a R5 moiety to P; each occurrence of R2 and R5 is independently an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, or H; and each occurrence of R6 is independently —PK(YR5)(YR5), —SO2(YR5) or —C(O)(YR5); so long as any R2, or R5 moiety linked directly to P is not H; wherein two R2, R5 and/or R6 moieties may be chemically linked to one another to form a ring; each occurrence of G is independently —O—, —S—, —NR2— or (M)x; each occurrence of M is independently a substituted or unsubstituted methylene moiety, and any M–M? moiety
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: March 6, 2007
    Assignee: ARIAD Gene Therapeutics, Inc.
    Inventors: Chester A. Metcalf, III, Leonard W. Rozamus, Yihan Wang, David L. Berstein
  • Phosphorus-containing macrocycles
    Publication number: 20060264405
    Abstract: This invention concerns a new family of phosphorus-containing macrocycles containing various phosphonate- and phosphonate-containing moieties.
    Type: Application
    Filed: May 5, 2006
    Publication date: November 23, 2006
    Inventors: Chester Metcalf, Leonard Rozamus, Yihan Wang, R. Thomas, Dong Zou, David Berstein
  • Phosphorus-containing compounds & uses thereof
    Publication number: 20060264456
    Abstract: This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA- in which: A is absent or is —O—, —S— or —NR2—; Q is absent or (if A is —O—, —S— or —NR2—) Q may be —V—, —OV—, —SV—, or —NR2V—, where V is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, such that J is linked to the cyclohexyl ring directly, through A or through VA, OVA, SVA or NR2VA; K is O or S; each occurrence of Y is independently —O—, —S—, —NR2—, or a bond linking a R5 moiety to P; each occurrence of R2 and R5 is independently an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, or H; and each occurrence of R6 is independently —PK(YR5)(YR5), —SO2(YR5) or —(O)(YR5); so long as any R2, or R5 moiety linked directly to P is not H; wherein two R2, R5 and/or R6 moieties may be chemically linked to one another to form a ring; each occurrence of G is independently —O—, —S—, —NR2— or (M)x; each occurrence of M is independently a substituted or unsubstituted methylene moiety, and any M-M? moie
    Type: Application
    Filed: July 27, 2006
    Publication date: November 23, 2006
    Inventors: Chester Metcalf, Leonard Rozamus, Yihan Wang, David Berstein
  • Quinazolines and uses thereof
    Patent number: 7132427
    Abstract: This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: November 7, 2006
    Assignee: Ariad Pharmaceuticals, Inc.
    Inventors: Yihan Wang, Chester A. Metcalf, III, William C. Shakespeare, Tomi K. Sawyer, Regine Bohacek, Rajeswari Sundaramoorthi
  • Purine derivatives
    Patent number: 7115589
    Abstract: This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use. In these compounds, RB is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety which comprises one or more phosphorus-containing moieties.
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: October 3, 2006
    Assignee: ARIAD Pharmaceuticals, Inc.
    Inventors: Manfred Weigele, Tomi K. Sawyer, Regine Bohacek, William C. Shakespeare, Rajeswari Sundaramoorthi, Yihan Wang, David C. Dalgarno, Chester A. Metcalf, III
  • Phosphorus-containing compounds and uses thereof
    Patent number: 7091213
    Abstract: This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA- in which: A is absent or is —O—, —S— or —NR2—; Q is absent or (if A is —O—, —S— or —NR2—) Q may be —V—, —OV—, —SV—, or —NR2V—, where V is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, such that J is linked to the cyclohexyl ring directly, through A or through VA, OVA, SVA or NR2VA; K is O or S; each occurrence of Y is independently —O—, —S—, —NR2—, or a bond linking a R5 moiety to P; each occurrence of R2 and R5 is independently an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, or H; and each occurrence of R6 is independently —PK(YR5)(YR5), —SO2(YR5) or —C(O)(YR5); so long as any R2, or R5 moiety linked directly to P is not H; wherein two R2, R5 and/or R6 moieties may be chemically linked to one another to form a ring; each occurrence of G is independently —O—, —S—, —NR2— or (M)x; each occurrence of M is independently a substituted or unsubstituted methylene moiety, and any M-M? moie
    Type: Grant
    Filed: June 4, 2004
    Date of Patent: August 15, 2006
    Assignee: ARIAD Gene Therapeutics, Inc.
    Inventors: Chester A. Metcalf, lll, Leonard W. Rozamus, Yihan Wang, David L. Berstein
  • Quinolinones and uses thereof
    Patent number: 7019139
    Abstract: The invention relates to compounds of the general formula (and pharmaceutically acceptable derivatives thereof): in which RA, RB, RC, RD, R5, R7, R9, R9a, AK, p, q, r and X are as defined herein, and to their preparation and use.
    Type: Grant
    Filed: November 17, 2003
    Date of Patent: March 28, 2006
    Assignee: ARIAD Pharmaceuticals, Inc.
    Inventors: Chester A. Metcalf, III, William C. Shakespeare, Tomi K. Sawyer, Yihan Wang, Regine Bohacek, Rajeswari Sundaramoorthi
  • Quinolines and uses thereof
    Patent number: 7009054
    Abstract: This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use.
    Type: Grant
    Filed: November 17, 2003
    Date of Patent: March 7, 2006
    Assignee: ARIAD Pharmaceuticals, Inc.
    Inventors: Yihan Wang, Chester A. Metcalf, III, William C. Shakespeare, Tomi K. Sawyer, Regine Bohacek, Rajeswari Sundaramoorthi
  • Indolinones and uses thereof
    Patent number: 6960572
    Abstract: This invention relates to compounds of the general formula: in which RA, RB, RC, RD, RE, p, q and X are as defined herein, and to their preparation and use.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: November 1, 2005
    Assignee: Ariad Pharmaceuticals, Inc.
    Inventors: William C. Shakespeare, Tomi K. Sawyer, Chester A. Metcalf, III, Yihan Wang, Regine Bohacek
  • Novel perines
    Publication number: 20050096298
    Abstract: Novel purines and uses of these compounds for the treatment of bone related disorders and cancer is disclosed.
    Type: Application
    Filed: November 22, 2004
    Publication date: May 5, 2005
    Inventors: Chester Metcalf, Manfred Weigele, Tomi Sawyer, Regine Bohacek, William Shakespeare, Rajeswari Sundaramoorthi, Yihan Wang, David Dalgarno
  • Phenylamino-pyrimidines and uses thereof
    Patent number: 6878697
    Abstract: This invention relates to compounds of the general formula: in which RA, RB, RC, RD, w, x, y, and z are as defined herein, and to their preparation and use.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: April 12, 2005
    Assignee: Ariad Pharmaceuticals, Inc.
    Inventors: Chester A. Metcalf, III, William C. Shakespeare, Tomi K. Sawyer, Yihan Wang, Regine Bohacek
  • Substituted purine derivatives
    Publication number: 20050065171
    Abstract: This invention relates to compounds of the general formula: in which Y, RA, RC and R6 are as defined herein, and to their preparation and use.
    Type: Application
    Filed: June 24, 2004
    Publication date: March 24, 2005
    Inventors: William Shakespeare, Chester Metcalf, Tomi Sawyer, Yihan Wang, Rajeswari Sundaramoorthi, David Dalgarno, Regine Bohacek, Manfred Weigele
  • Phosphorus-containing compounds and uses thereof
    Publication number: 20050032825
    Abstract: This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA— in which: A is absent or is —O—, —S— or —NR2—; Q is absent or (if A is —O—, —S— or —NR2—) Q may be —V—, —OV—, —SV—, or —NR2V—, where V is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, such that J is linked to the cyclohexyl ring directly, through A or through VA, OVA, SVA or NR2VA; K is O or S; each occurrence of Y is independently —O—, —S—, —NR2—, or a bond linking a R5 moiety to P; each occurrence of R2 and R5 is independently an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, or H; and each occurrence of R6 is independently —PK(YR5)(YR5), —SO2(YR5) or —C(O)(YR5); so long as any R2, or R5 moiety linked directly to P is not H; wherein two R2, R5 and/or R6 moieties may be chemically linked to one another to form a ring; each occurrence of G is independently —O—, —S—, —NR2— or (M)X; each occurrence of M is independently a substituted or unsubstituted methylene moiety, and any M-M? m
    Type: Application
    Filed: June 4, 2004
    Publication date: February 10, 2005
    Inventors: Chester Metcalf, Leonard Rozamus, Yihan Wang, David Berstein
  • Phosphorus-containing macrocycles
    Publication number: 20050026868
    Abstract: This invention concerns a new family of phosphorus-containing macrocycles containing various phosphonate- and phosphonate-containing moieties.
    Type: Application
    Filed: July 12, 2004
    Publication date: February 3, 2005
    Inventors: Chester Metcalf, Leonard Rozamus, Yihan Wang
  • NOVEL PHENYLAMINO-PYRIMIDINES AND USES THEREOF
    Publication number: 20040242611
    Abstract: This invention relates to compounds of the general formula: 1
    Type: Application
    Filed: June 21, 2002
    Publication date: December 2, 2004
    Inventors: Chester A. Metcalf, William C. Shakespeare, Tomi K. Sawyer, Yihan Wang, Regine Bohacek
  • Novel quinolinones and uses thereof
    Publication number: 20040167101
    Abstract: The invention relates to compounds of the general formula (and pharmaceutically acceptable derivatives thereof): 1
    Type: Application
    Filed: November 17, 2003
    Publication date: August 26, 2004
    Inventors: Chester A. Metcalf, William C. Shakespeare, Tomi K. Sawyer, Yihan Wang, Regine Bohacek, Rajeswari Sundaramoorthi
  • Novel quinolines and uses thereof
    Publication number: 20040152671
    Abstract: This invention relates to compounds of the general formula: 1
    Type: Application
    Filed: November 17, 2003
    Publication date: August 5, 2004
    Applicant: ARIAD Pharmaceuticals, Inc.
    Inventors: Yihan Wang, Chester A. Metcalf, William C. Shakespeare, Tomi K. Sawyer, Regine Bohacek, Rajeswari Sundaramoorthi
  • Phosphorus-containing compounds and uses thereof
    Publication number: 20040073024
    Abstract: This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA- in which:
    Type: Application
    Filed: August 6, 2003
    Publication date: April 15, 2004
    Inventors: Chester A. Metcalf, Leonard W. Rozamus, Yihan Wang, David L. Berstein