Patents by Inventor Chester B. Whitley

Chester B. Whitley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRISPR-MEDIATED HUMAN GENOME EDITING WITH VECTORS
    Publication number: 20230416776
    Abstract: Compositions and methods for Cas-based ex vivo and in vivo gene therapy applications are provided.
    Type: Application
    Filed: October 8, 2020
    Publication date: December 28, 2023
    Inventors: Li Ou, Chester B. Whitley
  • MODIFIED HEXOSAMINIDASE AND USES THEREOF
    Publication number: 20230374483
    Abstract: The disclosure provides for vectors encoding a fusion polypeptide comprising a modified hexosaminidase beta-subunit that forms homodimers, a linker and an ApoE peptide that allows for transport across the blood brain barrier, the encoded polypeptide, and methods of using the vector or polypeptide.
    Type: Application
    Filed: July 8, 2021
    Publication date: November 23, 2023
    Inventors: Li Ou, Chester B. Whitley
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROLOGIC DISEASE
    Publication number: 20230330195
    Abstract: Nucleases and methods of using these nucleases for inserting a sequence encoding a therapeutic IDUA or IDS protein such as an enzyme into a cell, thereby providing proteins or cell therapeutics for treatment and/or prevention of MPS I or MPS II disease.
    Type: Application
    Filed: October 24, 2022
    Publication date: October 19, 2023
    Inventors: Russell DeKelver, R. Scott McIvor, Li Ou, Thomas Wechsler, Chester B. Whitley, Kanut Laoharawee
  • CRISPR-MEDIATED GENOME EDITING WITH VECTORS
    Publication number: 20230201373
    Abstract: Compositions and methods for Cas-based ex vivo and in vivo gene therapy applications are provided.
    Type: Application
    Filed: December 14, 2018
    Publication date: June 29, 2023
    Inventors: Li Ou, Chester B. Whitley, Michael Przybilla
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROLOGIC DISEASE
    Publication number: 20170202931
    Abstract: Nucleases and methods of using these nucleases for inserting a sequence encoding a therapeutic IDUA or IDS protein such as an enzyme into a cell, thereby providing proteins or cell therapeutics for treatment and/or prevention of MPS I or MPS II disease.
    Type: Application
    Filed: January 12, 2017
    Publication date: July 20, 2017
    Inventors: Russell DeKelver, R. Scott McIvor, Li Ou, Thomas Wechsler, Chester B. Whitley
  • Methods of treating lysosomal storage related diseases by gene therapy
    Publication number: 20100068183
    Abstract: Isolated nucleic acid-based vectors and lentivirus vectors, and methods of using those vectors to inhibit or prevent metabolic disorders in a mammal, are provided.
    Type: Application
    Filed: September 21, 2009
    Publication date: March 18, 2010
    Inventors: Chester B. Whitley, R. Scott Mclvor
  • Methods of treating lysosomal storage related diseases by gene therapy
    Patent number: 7592321
    Abstract: Isolated nucleic acid-based vectors and lentivirus vectors, and methods of using those vectors to inhibit or prevent metabolic disorders in a mammal, are provided.
    Type: Grant
    Filed: February 14, 2005
    Date of Patent: September 22, 2009
    Inventors: Chester B. Whitley, R. Scott McIvor
  • Method for the detection of mucopolysaccharide storage diseases
    Patent number: 5310646
    Abstract: A method for screening a patient for mucopolysaccharidoses is provided in which sample urine absorbed onto a porous sheet and dried is extracted with water. 1,9-dimethylmethylene blue dye reagent in buffer is added to the aqueous extract to produce a test solution which is assessed spectrophotometrically for color change indicative of mucopolysaccharidoses. The invention is particularly applicable to rapid and reliable mass screening and diagnosis of newborn infants.
    Type: Grant
    Filed: December 9, 1991
    Date of Patent: May 10, 1994
    Assignee: Regents of the University of Minnesota
    Inventor: Chester B. Whitley