Abstract: An apparatus for tissue therapy may include a sequentially-collapsing tissue interface for use with negative pressure. The apparatus may include a first manifold and a second manifold fluidly coupled to the first manifold through a constricted fluid path. A fluid conductor may fluidly couple the second manifold to the first manifold. The fluid conductor may constrict fluid flow between the first manifold and the second manifold. The apparatus may include a negative-pressure source fluidly coupled to the first manifold in some embodiments. A controller may be configured to operate a negative-pressure source to provide negative pressure to a tissue interface in a therapy sequence adapted to propagate a wave in the tissue site. Such motion may be particularly advantageous or beneficial for a variety of conditions, including lymphedema, edema, or venous insufficiency.

Abstract: Provided herein are biologically active solution compositions comprising one or more sacrificial proteolytic enzyme substrates, one or more preservatives, and one or more antimicrobial agents and methods of using the solution compositions to treat tissue sites, in particular chronic wounds. The compositions may be used in conjunction with negative pressure wound therapy to treat tissue sites.

Abstract: Provided herein are biologically active solution compositions comprising one or more sacrificial proteolytic enzyme substrates, one or more preservatives, and one or more antimicrobial agents and methods of using the solution compositions to treat tissue sites, in particular chronic wounds. The compositions may be used in conjunction with negative pressure wound therapy to treat tissue sites.

Abstract: Example embodiments of an apparatus for tissue therapy may comprise a sequentially-collapsing tissue interface for use with negative pressure. More generally, some embodiments may include a first manifold and a second manifold fluidly coupled to the first manifold through a constricted fluid path. A fluid conductor may fluidly couple the second manifold to the first manifold in some embodiments. The fluid conductor may constrict fluid flow between the first manifold and the second manifold. The apparatus may additionally comprise a negative-pressure source fluidly coupled to the first manifold in some embodiments. A controller may be configured to operate a negative-pressure source to provide negative pressure to a tissue interface in a therapy sequence adapted to propagate a wave in the tissue site. Such motion may be particularly advantageous or beneficial for a variety of conditions, including lymphedema, edema, or venous insufficiency.

Abstract: Systems, methods, and apparatuses for treating a tissue site are described. In some embodiments, the method may include receiving input information related to a tissue site of a patient, processing the input information in a processor to generate options for a user to select a desired action, and executing the desired action to provide output information related to the tissue site. The method may further include communicating the output information to a user via a communications network.

Abstract: Provided herein are biologically active solution compositions comprising one or more sacrificial proteolytic enzyme substrates, one or more preservatives, and one or more antimicrobial agents and methods of using the solution compositions to treat tissue sites, in particular chronic wounds. The compositions may be used in conjunction with negative pressure wound therapy to treat tissue sites.