Patents by Inventor Chester Sapino

Chester Sapino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6365742
    Abstract: A process for the preparation of thebaine, its salts such as the bitartrate, and analogues thereof, together with a novel intermediate useful in said process are disclosed. Thebaine bitartrate is itself useful in the preparation of oxycodone; analogues are useful in the preparation of analogous 14-hydroxymorphinones.
    Type: Grant
    Filed: May 15, 2000
    Date of Patent: April 2, 2002
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Bogdan Mudryk, Chester Sapino, Jen-Sen Dung, Alice Sebastian
  • Patent number: 6096923
    Abstract: A process for the preparation of a nitrosourea derivative, in particular 1,2-bis(2-chloroethyl)-1-nitrosourea, comprises reacting a non-nitrosated urea derivative with a metal nitrite in a two-phase solvent system comprising an aqueous acid and a non-miscible organic solvent.
    Type: Grant
    Filed: September 11, 1998
    Date of Patent: August 1, 2000
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Matthew P McWilliams, Chester Sapino
  • Patent number: 6096760
    Abstract: Methyl .alpha.-phenyl-2-piperidine acetate (free base) is disclosed as a crystalline solid, together with a method for its preparation; its use in medicine, in particular as a stimulant for the central nervous system; and pharmaceutical formulations comprising the compound, particularly transdermal patches.
    Type: Grant
    Filed: May 29, 1998
    Date of Patent: August 1, 2000
    Assignee: Johnson Matthey Public Limited Company
    Inventor: Chester Sapino
  • Patent number: 6090943
    Abstract: A process for the preparation of thebaine, its salts such as the bitartrate, and analogues thereof, together with a novel intermediate useful in said process are disclosed. Thebaine bitartrate is itself useful in the preparation of oxycodone; analogues are useful in the preparation of analogous 14-hydroxymorphinones.
    Type: Grant
    Filed: June 30, 1998
    Date of Patent: July 18, 2000
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Bogdan Mudryk, Chester Sapino, Jen-Sen Dung, Alice Sebastian
  • Patent number: 5981751
    Abstract: A method for removing residual organic solvents from a bulk substance, for example from a pharmaceutical drug substance, comprises drying the bulk substance in the presence of water vapor, such that the residual organic solvent molecules are displaced with water vapor molecules.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: November 9, 1999
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Bogdan Mudryk, Jen-Sen Dung, Chester Sapino, James Guro
  • Patent number: 5847142
    Abstract: A novel process for preparing narcotic analgesics such as hydrocodone and hydromorphone using catalytic amounts of homogeneous organometallic complexes is disclosed.
    Type: Grant
    Filed: April 3, 1997
    Date of Patent: December 8, 1998
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Bogdan Mudryk, Joydeep Kant, Chester Sapino
  • Patent number: 5591852
    Abstract: The present invention relates to a novel and economical process for the synthesis of HPMP-substituted nucleotide antiviral compounds. Also disclosed are novel intermediates produced in the process for the preparation of HPMPC.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 7, 1997
    Assignees: Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v.z.w.
    Inventors: Purushotham Vemishetti, Paul R. Brodfuehrer, Henry G. Howell, Chester Sapino, Jr.
  • Patent number: 5476938
    Abstract: The present invention relates to a novel and economical process for the synthesis of HPMP-substituted nucleotide antiviral compounds. Also disclosed are novel intermediates produced in the process for the preparation of HPMPC.
    Type: Grant
    Filed: January 21, 1992
    Date of Patent: December 19, 1995
    Assignees: Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v.z.w.
    Inventors: Purushortham Vemishetti, Paul R. Brodfuehrer, Henry G. Howell, Chester Sapino, Jr.
  • Patent number: 5420269
    Abstract: 3-Fluorosulfonyloxyceph-3-ems having a protected amino or acylamino group in the 7-position are subject to carbon-carbon bond formation at the 3-position by means of a palladium catalyzed coupling reaction with substituted organostannanes. A process for preparing cefprozil is disclosed.
    Type: Grant
    Filed: June 15, 1993
    Date of Patent: May 30, 1995
    Assignee: Bristol-Myers Squibb Co
    Inventors: Stephen R. Baker, Chester Sapino, Jr., Gregory P. Roth
  • Patent number: 5245027
    Abstract: 3-Fluorosulfonyloxyceph-3-ems having a protected amino or acylamino group in the 7-position are subject to carbon-carbon bond formation at the 3-position by means of a palladium catalyzed coupling reaction with substituted organostannanes. A process for preparing cefprozil is disclosed.
    Type: Grant
    Filed: October 31, 1990
    Date of Patent: September 14, 1993
    Assignee: Bristol-Myers Squibb Company
    Inventors: Stephen R. Baker, Chester Sapino, Jr., Gregory P. Roth
  • Patent number: 5043439
    Abstract: Cephalosporin intermediates having a replacable organosulfonylyoxy or heterocyclothio group in the 3-position undergo a carbon alkylation process with organocopper reagents to provide 3-hydrocarbon substituted cephalosporin antibiotics.
    Type: Grant
    Filed: March 8, 1990
    Date of Patent: August 27, 1991
    Assignee: Bristol-Myers Squibb Company
    Inventors: Joydeep Kant, Chester Sapino, Jr.
  • Patent number: 4879377
    Abstract: Process for producing 1-halo-2-deoxy-2-fluoroarabinofuranoside derivatives bearing protective ester groups from 1,3,5-tri-O-acylribofuranose; the 1-halo compounds are intermediates in the synthesis of therapeutically active nucleosidic compounds.
    Type: Grant
    Filed: July 28, 1988
    Date of Patent: November 7, 1989
    Assignee: Bristol-Myers Company
    Inventors: Steven P. Brundidge, Henry G. Howell, Chester Sapino, Jr., Chou Hong-Tann
  • Patent number: 4870168
    Abstract: There is disclosed a process for the production of certain 3-hydrocarbyl-3-cephem derivatives wherein the hydrocarbyl group is selected from 1-alkenyl and conjugated and unconjugated 1-polyalkenyl, 1-alkynl, carbocyclic and heterocyclic aryl, and carbocyclic and heterocyclic arylmethyl and, in the case of the 1-alkenyl and conjugated 1-polyalkenyl derivatives, with substantially complete stereospecificity, by coupling a 3-triflyloxy cephem with a hydrocarbyltributylstannane in the presence of bis(dibenzylideneacetonyl)-palladium, a phosphine, and a metal halide such as, for example, zinc chloride. The 3-unsaturated alkyl-3-cephem derivatives so-produced are useful as broad-spectrum antibacterial agents.
    Type: Grant
    Filed: February 26, 1987
    Date of Patent: September 26, 1989
    Assignee: Bristol-Myers Company
    Inventors: Stephen R. Baker, Vittorio Farina, Chester Sapino, Jr.
  • Patent number: 4847373
    Abstract: There is disclosed a process for the production of certain 2-allyl- and 3-butenyl-3-cephem derivatives by coupling a 3-chloromethyl-3-cephem with a hydrocarbyltributystannane in the presence of bis(dibenzylideneacetonyl)-palladium and a phosphine. The 3-allyl- and 3-butenyl-3-cephem derivatives so-produced are useful as broad-spectrum antibacterial agents.
    Type: Grant
    Filed: February 26, 1987
    Date of Patent: July 11, 1989
    Assignee: Bristol-Myers Company
    Inventors: Stephen R. Baker, Vittorio Farina, Chester Sapino, Jr.
  • Patent number: 4625020
    Abstract: Process for producing 1-halo-2-deoxy-2-fluoroarabinofuranoside derivatives bearing protective ester groups from 1,3,5-tri-O-acylribofuranose; the 1-halo compounds are intermediates in the synthesis of therapeutically active nucleosidic compounds.
    Type: Grant
    Filed: November 18, 1983
    Date of Patent: November 25, 1986
    Assignee: Bristol-Myers Company
    Inventors: Steven P. Brundidge, Henry G. Howell, Chester Sapino, Jr., Chon-Hong Tann
  • Patent number: 4351766
    Abstract: Trimethylsilyl or another easily hydrolyzed ester of 6-trimethylsilyloxycarbonylaminopenicillanic acid was prepared by bubbling dry carbon dioxide into an anhydrous solution of the corresponding 6-trimethylsilylaminopenicillanate and found to be a useful intermediate in the production of penicillins, e.g., amoxicillin and ampicillin, by its acylation in anhydrous media with the appropriate acid chloride or acid chloride hydrochloride.
    Type: Grant
    Filed: August 13, 1981
    Date of Patent: September 28, 1982
    Assignee: Bristol-Myers Company
    Inventors: Derek Walker, Herbert H. Silvestri, Chester Sapino, David A. Johnson
  • Patent number: 4316017
    Abstract: In the preferred embodiment of the present invention trimethylsilyl 7-trimethylsilyloxycarbonylaminodecephalosporanate was prepared by bubbling dry carbon dioxide into an anhydrous solution of trimethylsilyl 6-trimethylsilylaminodecephalosporanate and found to be a useful intermediate in the production of cefadroxil and cephalexin by its acylation in anhydrous media with the appropriate 2-phenylglycyl chloride hydrochloride. Other cephalosporins are produced by acylation of 7-trimethylsilyloxycarbonylaminoceph-3-em-4-carboxylic acids or esters having a variety of substituents at the 3-position.
    Type: Grant
    Filed: June 11, 1980
    Date of Patent: February 16, 1982
    Assignee: Bristol-Myers Company
    Inventors: Derek Walker, Herbert H. Silvestri, Chester Sapino, David A. Johnson
  • Patent number: 4316016
    Abstract: In the preferred embodiment of the present invention trimethylsilyl 7-trimethylsilyloxycarbonylaminodecephalosporanate was prepared by bubbling dry carbon dioxide into an ahydrous solution of trimethylsilyl 6-trimethylsilylaminodecephalosporanate and found to be a useful intermediate in the production of cefadroxil and cephalexin by its acylation in anhydrous media with the appropriate 2-phenylglycyl chloride hydrochloride. Other cephalosporins are produced by acylation of 7-trimethylsilyloxycarbonylaminoceph-3-em-4-carboxylic acids or esters having a variety of substituents at the 3-position.
    Type: Grant
    Filed: June 11, 1980
    Date of Patent: February 16, 1982
    Assignee: Bristol-Myers Company
    Inventors: Derek Walker, Herbert H. Silvestri, Chester Sapino, David A. Johnson
  • Patent number: 4310458
    Abstract: Trimethylsilyl or another easily hydrolyzed ester of 6-trimethylsilyloxycarbonylaminopenicillanic acid was prepared by bubbling dry carbon dioxide into an anhydrous solution of the corresponding 6-trimethylsilylaminopenicillanate and found to be a useful intermediate in the production of penicillins, e.g., amoxicillin and ampicillin, by its acylation in anhydrous media with the appropriate acid chloride or acid chloride hydrochloride.
    Type: Grant
    Filed: July 12, 1979
    Date of Patent: January 12, 1982
    Assignee: Bristol-Myers Company
    Inventors: Derek Walker, Herbert H. Silvestri, Chester Sapino, David A. Johnson
  • Patent number: 4278600
    Abstract: Trimethylsilyl or another easily hydrolyzed ester of 6-trimethylsilyloxycarbonylaminopenicillanic acid was prepared by bubbling dry carbon dioxide into ananhydrous solution of the corresponding 6-trimethylsilylaminopenicillanate and found to be a useful intermediate in the production of penicillins, e.g., amoxicillin and ampicillin, by its acylation in anhydrous media with the appropriate acid chloride or acid chloride hydrochloride.
    Type: Grant
    Filed: July 20, 1979
    Date of Patent: July 14, 1981
    Assignee: Bristol-Myers Company
    Inventors: Derek Walker, Herbert H. Silvestri, Chester Sapino, David A. Johnson