Patents by Inventor Chester Sapino
Chester Sapino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6365742Abstract: A process for the preparation of thebaine, its salts such as the bitartrate, and analogues thereof, together with a novel intermediate useful in said process are disclosed. Thebaine bitartrate is itself useful in the preparation of oxycodone; analogues are useful in the preparation of analogous 14-hydroxymorphinones.Type: GrantFiled: May 15, 2000Date of Patent: April 2, 2002Assignee: Johnson Matthey Public Limited CompanyInventors: Bogdan Mudryk, Chester Sapino, Jen-Sen Dung, Alice Sebastian
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Patent number: 6096760Abstract: Methyl .alpha.-phenyl-2-piperidine acetate (free base) is disclosed as a crystalline solid, together with a method for its preparation; its use in medicine, in particular as a stimulant for the central nervous system; and pharmaceutical formulations comprising the compound, particularly transdermal patches.Type: GrantFiled: May 29, 1998Date of Patent: August 1, 2000Assignee: Johnson Matthey Public Limited CompanyInventor: Chester Sapino
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Patent number: 6096923Abstract: A process for the preparation of a nitrosourea derivative, in particular 1,2-bis(2-chloroethyl)-1-nitrosourea, comprises reacting a non-nitrosated urea derivative with a metal nitrite in a two-phase solvent system comprising an aqueous acid and a non-miscible organic solvent.Type: GrantFiled: September 11, 1998Date of Patent: August 1, 2000Assignee: Johnson Matthey Public Limited CompanyInventors: Matthew P McWilliams, Chester Sapino
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Patent number: 6090943Abstract: A process for the preparation of thebaine, its salts such as the bitartrate, and analogues thereof, together with a novel intermediate useful in said process are disclosed. Thebaine bitartrate is itself useful in the preparation of oxycodone; analogues are useful in the preparation of analogous 14-hydroxymorphinones.Type: GrantFiled: June 30, 1998Date of Patent: July 18, 2000Assignee: Johnson Matthey Public Limited CompanyInventors: Bogdan Mudryk, Chester Sapino, Jen-Sen Dung, Alice Sebastian
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Patent number: 5981751Abstract: A method for removing residual organic solvents from a bulk substance, for example from a pharmaceutical drug substance, comprises drying the bulk substance in the presence of water vapor, such that the residual organic solvent molecules are displaced with water vapor molecules.Type: GrantFiled: August 21, 1998Date of Patent: November 9, 1999Assignee: Johnson Matthey Public Limited CompanyInventors: Bogdan Mudryk, Jen-Sen Dung, Chester Sapino, James Guro
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Patent number: 5847142Abstract: A novel process for preparing narcotic analgesics such as hydrocodone and hydromorphone using catalytic amounts of homogeneous organometallic complexes is disclosed.Type: GrantFiled: April 3, 1997Date of Patent: December 8, 1998Assignee: Johnson Matthey Public Limited CompanyInventors: Bogdan Mudryk, Joydeep Kant, Chester Sapino
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Patent number: 5591852Abstract: The present invention relates to a novel and economical process for the synthesis of HPMP-substituted nucleotide antiviral compounds. Also disclosed are novel intermediates produced in the process for the preparation of HPMPC.Type: GrantFiled: June 7, 1995Date of Patent: January 7, 1997Assignees: Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v.z.w.Inventors: Purushotham Vemishetti, Paul R. Brodfuehrer, Henry G. Howell, Chester Sapino, Jr.
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Patent number: 5476938Abstract: The present invention relates to a novel and economical process for the synthesis of HPMP-substituted nucleotide antiviral compounds. Also disclosed are novel intermediates produced in the process for the preparation of HPMPC.Type: GrantFiled: January 21, 1992Date of Patent: December 19, 1995Assignees: Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v.z.w.Inventors: Purushortham Vemishetti, Paul R. Brodfuehrer, Henry G. Howell, Chester Sapino, Jr.
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Patent number: 5420269Abstract: 3-Fluorosulfonyloxyceph-3-ems having a protected amino or acylamino group in the 7-position are subject to carbon-carbon bond formation at the 3-position by means of a palladium catalyzed coupling reaction with substituted organostannanes. A process for preparing cefprozil is disclosed.Type: GrantFiled: June 15, 1993Date of Patent: May 30, 1995Assignee: Bristol-Myers Squibb CoInventors: Stephen R. Baker, Chester Sapino, Jr., Gregory P. Roth
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Patent number: 5245027Abstract: 3-Fluorosulfonyloxyceph-3-ems having a protected amino or acylamino group in the 7-position are subject to carbon-carbon bond formation at the 3-position by means of a palladium catalyzed coupling reaction with substituted organostannanes. A process for preparing cefprozil is disclosed.Type: GrantFiled: October 31, 1990Date of Patent: September 14, 1993Assignee: Bristol-Myers Squibb CompanyInventors: Stephen R. Baker, Chester Sapino, Jr., Gregory P. Roth
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Patent number: 5043439Abstract: Cephalosporin intermediates having a replacable organosulfonylyoxy or heterocyclothio group in the 3-position undergo a carbon alkylation process with organocopper reagents to provide 3-hydrocarbon substituted cephalosporin antibiotics.Type: GrantFiled: March 8, 1990Date of Patent: August 27, 1991Assignee: Bristol-Myers Squibb CompanyInventors: Joydeep Kant, Chester Sapino, Jr.
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Patent number: 4879377Abstract: Process for producing 1-halo-2-deoxy-2-fluoroarabinofuranoside derivatives bearing protective ester groups from 1,3,5-tri-O-acylribofuranose; the 1-halo compounds are intermediates in the synthesis of therapeutically active nucleosidic compounds.Type: GrantFiled: July 28, 1988Date of Patent: November 7, 1989Assignee: Bristol-Myers CompanyInventors: Steven P. Brundidge, Henry G. Howell, Chester Sapino, Jr., Chou Hong-Tann
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Patent number: 4870168Abstract: There is disclosed a process for the production of certain 3-hydrocarbyl-3-cephem derivatives wherein the hydrocarbyl group is selected from 1-alkenyl and conjugated and unconjugated 1-polyalkenyl, 1-alkynl, carbocyclic and heterocyclic aryl, and carbocyclic and heterocyclic arylmethyl and, in the case of the 1-alkenyl and conjugated 1-polyalkenyl derivatives, with substantially complete stereospecificity, by coupling a 3-triflyloxy cephem with a hydrocarbyltributylstannane in the presence of bis(dibenzylideneacetonyl)-palladium, a phosphine, and a metal halide such as, for example, zinc chloride. The 3-unsaturated alkyl-3-cephem derivatives so-produced are useful as broad-spectrum antibacterial agents.Type: GrantFiled: February 26, 1987Date of Patent: September 26, 1989Assignee: Bristol-Myers CompanyInventors: Stephen R. Baker, Vittorio Farina, Chester Sapino, Jr.
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Patent number: 4847373Abstract: There is disclosed a process for the production of certain 2-allyl- and 3-butenyl-3-cephem derivatives by coupling a 3-chloromethyl-3-cephem with a hydrocarbyltributystannane in the presence of bis(dibenzylideneacetonyl)-palladium and a phosphine. The 3-allyl- and 3-butenyl-3-cephem derivatives so-produced are useful as broad-spectrum antibacterial agents.Type: GrantFiled: February 26, 1987Date of Patent: July 11, 1989Assignee: Bristol-Myers CompanyInventors: Stephen R. Baker, Vittorio Farina, Chester Sapino, Jr.
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Patent number: 4625020Abstract: Process for producing 1-halo-2-deoxy-2-fluoroarabinofuranoside derivatives bearing protective ester groups from 1,3,5-tri-O-acylribofuranose; the 1-halo compounds are intermediates in the synthesis of therapeutically active nucleosidic compounds.Type: GrantFiled: November 18, 1983Date of Patent: November 25, 1986Assignee: Bristol-Myers CompanyInventors: Steven P. Brundidge, Henry G. Howell, Chester Sapino, Jr., Chon-Hong Tann
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Patent number: 4351766Abstract: Trimethylsilyl or another easily hydrolyzed ester of 6-trimethylsilyloxycarbonylaminopenicillanic acid was prepared by bubbling dry carbon dioxide into an anhydrous solution of the corresponding 6-trimethylsilylaminopenicillanate and found to be a useful intermediate in the production of penicillins, e.g., amoxicillin and ampicillin, by its acylation in anhydrous media with the appropriate acid chloride or acid chloride hydrochloride.Type: GrantFiled: August 13, 1981Date of Patent: September 28, 1982Assignee: Bristol-Myers CompanyInventors: Derek Walker, Herbert H. Silvestri, Chester Sapino, David A. Johnson
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Patent number: 4316016Abstract: In the preferred embodiment of the present invention trimethylsilyl 7-trimethylsilyloxycarbonylaminodecephalosporanate was prepared by bubbling dry carbon dioxide into an ahydrous solution of trimethylsilyl 6-trimethylsilylaminodecephalosporanate and found to be a useful intermediate in the production of cefadroxil and cephalexin by its acylation in anhydrous media with the appropriate 2-phenylglycyl chloride hydrochloride. Other cephalosporins are produced by acylation of 7-trimethylsilyloxycarbonylaminoceph-3-em-4-carboxylic acids or esters having a variety of substituents at the 3-position.Type: GrantFiled: June 11, 1980Date of Patent: February 16, 1982Assignee: Bristol-Myers CompanyInventors: Derek Walker, Herbert H. Silvestri, Chester Sapino, David A. Johnson
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Patent number: 4316017Abstract: In the preferred embodiment of the present invention trimethylsilyl 7-trimethylsilyloxycarbonylaminodecephalosporanate was prepared by bubbling dry carbon dioxide into an anhydrous solution of trimethylsilyl 6-trimethylsilylaminodecephalosporanate and found to be a useful intermediate in the production of cefadroxil and cephalexin by its acylation in anhydrous media with the appropriate 2-phenylglycyl chloride hydrochloride. Other cephalosporins are produced by acylation of 7-trimethylsilyloxycarbonylaminoceph-3-em-4-carboxylic acids or esters having a variety of substituents at the 3-position.Type: GrantFiled: June 11, 1980Date of Patent: February 16, 1982Assignee: Bristol-Myers CompanyInventors: Derek Walker, Herbert H. Silvestri, Chester Sapino, David A. Johnson
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Patent number: 4310458Abstract: Trimethylsilyl or another easily hydrolyzed ester of 6-trimethylsilyloxycarbonylaminopenicillanic acid was prepared by bubbling dry carbon dioxide into an anhydrous solution of the corresponding 6-trimethylsilylaminopenicillanate and found to be a useful intermediate in the production of penicillins, e.g., amoxicillin and ampicillin, by its acylation in anhydrous media with the appropriate acid chloride or acid chloride hydrochloride.Type: GrantFiled: July 12, 1979Date of Patent: January 12, 1982Assignee: Bristol-Myers CompanyInventors: Derek Walker, Herbert H. Silvestri, Chester Sapino, David A. Johnson
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Patent number: 4278600Abstract: Trimethylsilyl or another easily hydrolyzed ester of 6-trimethylsilyloxycarbonylaminopenicillanic acid was prepared by bubbling dry carbon dioxide into ananhydrous solution of the corresponding 6-trimethylsilylaminopenicillanate and found to be a useful intermediate in the production of penicillins, e.g., amoxicillin and ampicillin, by its acylation in anhydrous media with the appropriate acid chloride or acid chloride hydrochloride.Type: GrantFiled: July 20, 1979Date of Patent: July 14, 1981Assignee: Bristol-Myers CompanyInventors: Derek Walker, Herbert H. Silvestri, Chester Sapino, David A. Johnson