Patents by Inventor Chet Berman

Chet Berman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for performing continuous directed evolution
    Patent number: 11414677
    Abstract: Disclosed herein are methods of performing continuous directed evolution in complex biological systems, including metazoan cells. These methods include the infection of engineered, non-naturally occurring metazoan cells with engineered, non-naturally occurring DNA viruses. The generation of infectious viruses that can infect new cells depends on the evolution of a gene of interest which is driven by an error-prone adenoviral polymerase. Also disclosed herein, are the compositions of engineered, non-naturally occurring metazoan cells and engineered, non-naturally occurring DNA viruses that function as components in the continuous directed evolution methodologies.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: August 16, 2022
    Assignee: Massachusetts Institute of Technology
    Inventors: Matthew D. Shoulders, Chet Berman, Christopher Lawrence Moore, Louis John Papa, Samuel Joseph Hendel
  • METHODS AND COMPOSITIONS FOR PERFORMING CONTINUOUS DIRECTED EVOLUTION
    Publication number: 20190153472
    Abstract: Disclosed herein are methods of performing continuous directed evolution in complex biological systems, including metazoan cells. These methods include the infection of engineered, non-naturally occurring metazoan cells with engineered, non-naturally occurring DNA viruses. The generation of infectious viruses that can infect new cells depends on the evolution of a gene of interest which is driven by an error-prone adenoviral polymerase. Also disclosed herein, are the compositions of engineered, non-naturally occurring metazoan cells and engineered, non-naturally occurring DNA viruses that function as components in the continuous directed evolution methodologies.
    Type: Application
    Filed: October 26, 2018
    Publication date: May 23, 2019
    Applicant: Massachusetts Institute of Technology
    Inventors: Matthew D. Shoulders, Chet Berman, Christopher Lawrence Moore, Louis John Papa, Samuel Joseph Hendel