Abstract: A fetal movement monitoring method that limits the ultrasound radiation to safe levels and conforms to the ALARA principle is disclosed. The disclosed method of monitoring fetal movements by Doppler ultrasound comprises accumulating the time for which ultrasound is radiated into a subject, comparing the accumulated time with a first reference total time, counting the number of fetal movements in the subject, comparing the number of movements with a reference number, deciding at least one of a further action of the device and an action to be recommended to the subject and conveying at least one of a further action of the device, an information to the subject about the counted fetal movements and an action recommended to the subject. A Doppler ultrasound device for monitoring fetal movements in a subject is also disclosed.

Abstract: The present invention relates to a method of non-invasively monitoring the expression of a gene of interest in a cell when contacting said cell with a compound influencing the expression of said gene of interest. The present invention is also concerned with different isolated nucleic acid molecules comprising a coding sequence. Said coding sequence comprises a gene of interest-sequence encoding a gene of interest-polypeptide fused to a reporter sequence encoding a fluorescent reporter polypeptide and is operatively coupled to a promoter sequence. The present invention is also concerned with the use of a method and a nucleic acid molecule of the invention for delivering a compound influencing the expression of a gene of interest in a cell, monitoring the delivery of said compound as well as monitoring the influence on the expression of said gene of interest induced by said compound at the same time.

Abstract: A device for independently and controllably amplifying components of the heart sound signals without removing any component of the signal by filtering. With such a device all the signal components that carry information are still available and can be useful to a user. Filtering may however be applied to very high frequency signals, compared to the signal of interest, that are totally unrelated to the heart sounds.

Abstract: A device for independently and controllably amplifying components of the heart sound signals without removing any component of the signal by filtering. With such a device all the signal components that carry information are still available and can be useful to a user. Filtering may however be applied to very high frequency signals, compared to the signal of interest, that are totally unrelated to the heart sounds.

Abstract: A fetal movement monitoring method that limits the ultrasound radiation to safe levels and conforms to the ALARA principle is disclosed. The disclosed method of monitoring fetal movements by Doppler ultrasound comprises accumulating the time for which ultrasound is radiated into a subject, comparing the accumulated time with a first reference total time, counting the number of fetal movements in the subject, comparing the number of movements with a reference number, deciding at least one of a further action of the device and an action to be recommended to the subject and conveying at least one of a further action of the device, an information to the subject about the counted fetal movements and an action recommended to the subject. A Doppler ultrasound device for monitoring fetal movements in a subject is also disclosed.

Abstract: The present invention relates to a method for the detection of a DNA methylation signature associated with the presence of or the predisposition to develop a disorder, the method comprising the identification of one or more candidate genes exhibiting differential DNA methylation in target and reference samples as well as the respective determination of the nucleic acid sites in said candidate genes that are differentially methylated and the recognition sites for DNA binding factors, said DNA binding factors each recognizing such a differentially methylated nucleic acid site, wherein the patterns of differentially methylated nucleic acid sites and of DNA binding factor recognition sites obtained together represent a DNA methylation signature that is indicative for the presence of or the predisposition to develop a disorder in a target sample.

Abstract: The present invention relates a method for analyzing a DNA sequence. The DNA sequence by converting the DNA sequence into a plurality of binary indicator sequences (BIS), and applying short term Fourier transform (STFT) on the binary indicator sequences. A binning function (BF) is applied to the Fourier coefficients (Usk_X(k)) and thereby modifying the corresponding Fourier coefficients (Usk_X(k)). Finally, substantially equal modified Fourier coefficients (Usk_X(k)) is found. The invention provides the user with a much improved ability to see unique strong patterns in vast amount of DNA sequence data.