Patents by Inventor Chethan Ashokkumar
Chethan Ashokkumar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10928384Abstract: Disclosed herein are methods for diagnosing or predicting acute cellular and/or humoral rejection in a subject. In one example, a method of assessing organ rejection includes contacting a first sample comprising antigen presenting cells (APCs) obtained from a subject in need of or having received an organ transplant with a donor antigen from a donor under conditions sufficient to induce uptake of the donor antigen; contacting a second sample comprising APCs obtained from the subject in need of or having received an organ transplant with a third-party antigen under conditions sufficient to induce uptake of the third-party antigen; and determining an antigen presenting index by determining a ratio of uptake of the donor antigen in the first sample to uptake of the third-party antigen in the second sample, wherein the ratio of greater than one indicates organ rejection and the APCs are monocytes or monocyte-derived cells.Type: GrantFiled: September 25, 2018Date of Patent: February 23, 2021Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Rakesh Sindhi, Chethan AshokKumar
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Patent number: 10222374Abstract: Disclosed herein are methods for diagnosing or predicting B-cell rejection in a subject. In one example, for assessing transplant rejection, the method includes determining an antigen presenting index by comparing uptake of a donor antigen to uptake of a reference antigen in a biological sample obtained from the subject. In another example, for assessing GVHD, the method includes determining an antigen presenting index by comparing uptake of a recipient antigen to uptake of a reference antigen in a biological sample obtained from the subject.Type: GrantFiled: August 9, 2017Date of Patent: March 5, 2019Assignee: Univeersity of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Rakesh Sindhi, Chethan Ashokkumar
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Publication number: 20190025292Abstract: Disclosed herein are methods for diagnosing or predicting acute cellular and/or humoral rejection in a subject. In one example, a method of assessing organ rejection includes contacting a first sample comprising antigen presenting cells (APCs) obtained from a subject in need of or having received an organ transplant with a donor antigen from a donor under conditions sufficient to induce uptake of the donor antigen; contacting a second sample comprising APCs obtained from the subject in need of or having received an organ transplant with a third-party antigen under conditions sufficient to induce uptake of the third-party antigen; and determining an antigen presenting index by determining a ratio of uptake of the donor antigen in the first sample to uptake of the third-party antigen in the second sample, wherein the ratio of greater than one indicates organ rejection and the APCs are monocytes or monocyte-derived cells.Type: ApplicationFiled: September 25, 2018Publication date: January 24, 2019Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Rakesh Sindhi, Chethan AshokKumar
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Patent number: 10114011Abstract: Disclosed herein are methods for diagnosing or predicting acute cellular and/or humoral rejection in a subject. In one example, a method of assessing organ rejection includes contacting a first sample comprising antigen presenting cells (APCs) obtained from a subject in need of or having received an organ transplant with a donor antigen from a donor under conditions sufficient to induce uptake of the donor antigen; contacting a second sample comprising APCs obtained from the subject in need of or having received an organ transplant with a third-party antigen under conditions sufficient to induce uptake of the third-party antigen; and determining an antigen presenting index by determining a ratio of uptake of the donor antigen in the first sample to uptake of the third-party antigen in the second sample, wherein the ratio of greater than one indicates organ rejection and the APCs are monocytes or monocyte-derived cells.Type: GrantFiled: July 20, 2017Date of Patent: October 30, 2018Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Rakesh Sindhi, Chethan AshokKumar
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Publication number: 20170336411Abstract: Disclosed herein are methods for diagnosing or predicting B-cell rejection in a subject. In one example, for assessing transplant rejection, the method includes determining an antigen presenting index by comparing uptake of a donor antigen to uptake of a reference antigen in a biological sample obtained from the subject. In another example, for assessing GVHD, the method includes determining an antigen presenting index by comparing uptake of a recipient antigen to uptake of a reference antigen in a biological sample obtained from the subject.Type: ApplicationFiled: August 9, 2017Publication date: November 23, 2017Applicant: The University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Rakesh Sindhi, Chethan Ashokkumar
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Publication number: 20170322201Abstract: Disclosed herein are methods for diagnosing or predicting acute cellular and/or humoral rejection in a subject. In one example, a method of assessing organ rejection includes contacting a first sample comprising antigen presenting cells (APCs) obtained from a subject in need of or having received an organ transplant with a donor antigen from a donor under conditions sufficient to induce uptake of the donor antigen; contacting a second sample comprising APCs obtained from the subject in need of or having received an organ transplant with a third-party antigen under conditions sufficient to induce uptake of the third-party antigen; and determining an antigen presenting index by determining a ratio of uptake of the donor antigen in the first sample to uptake of the third-party antigen in the second sample, wherein the ratio of greater than one indicates organ rejection and the APCs are monocytes or monocyte-derived cells.Type: ApplicationFiled: July 20, 2017Publication date: November 9, 2017Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Rakesh Sindhi, Chethan AshokKumar
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Patent number: 9759723Abstract: Disclosed herein are methods for diagnosing or predicting B-cell rejection in a subject. In one example, for assessing transplant rejection, the method includes determining an antigen presenting index by comparing uptake of a donor antigen to uptake of a reference antigen in a biological sample obtained from the subject. In another example, for assessing GVHD, the method includes determining an antigen presenting index by comparing uptake of a recipient antigen to uptake of a reference antigen in a biological sample obtained from the subject.Type: GrantFiled: March 21, 2016Date of Patent: September 12, 2017Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Rakesh Sindhi, Chethan Ashokkumar
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Patent number: 9746459Abstract: Disclosed herein are methods for diagnosing or predicting acute cellular and/or humoral rejection in a subject. In one example, a method of assessing organ rejection includes contacting a first sample comprising antigen presenting cells (APCs) obtained from a subject in need of or having received an organ transplant with a donor antigen from a donor under conditions sufficient to induce uptake of the donor antigen; contacting a second sample comprising APCs obtained from the subject in need of or having received an organ transplant with a third-party antigen under conditions sufficient to induce uptake of the third-party antigen; and determining an antigen presenting index by determining a ratio of uptake of the donor antigen in the first sample to uptake of the third-party antigen in the second sample, wherein the ratio of greater than one indicates organ rejection and the APCs are monocytes or monocyte-derived cells.Type: GrantFiled: October 11, 2013Date of Patent: August 29, 2017Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Rakesh Sindhi, Chethan AshokKumar
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Publication number: 20160202258Abstract: Disclosed herein are methods for diagnosing or predicting B-cell rejection in a subject. In one example, for assessing transplant rejection, the method includes determining an antigen presenting index by comparing uptake of a donor antigen to uptake of a reference antigen in a biological sample obtained from the subject. In another example, for assessing GVHD, the method includes determining an antigen presenting index by comparing uptake of a recipient antigen to uptake of a reference antigen in a biological sample obtained from the subject.Type: ApplicationFiled: March 21, 2016Publication date: July 14, 2016Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Rakesh Sindhi, Chethan Ashokkumar
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Patent number: 9322827Abstract: Disclosed herein are methods for diagnosing or predicting B-cell rejection in a subject. In one example, for assessing transplant rejection, the method includes determining an antigen presenting index by comparing uptake of a donor antigen to uptake of a reference antigen in a biological sample obtained from the subject. In another example, for assessing GVHD, the method includes determining an antigen presenting index by comparing uptake of a recipient antigen to uptake of a reference antigen in a biological sample obtained from the subject.Type: GrantFiled: April 8, 2011Date of Patent: April 26, 2016Assignee: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Rakesh Sindhi, Chethan AshokKumar
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Publication number: 20140057315Abstract: Disclosed herein are methods for diagnosing or predicting acute cellular and/or humoral rejection in a subject. In one example, a method of assessing organ rejection includes contacting a first sample comprising antigen presenting cells (APCs) obtained from a subject in need of or having received an organ transplant with a donor antigen from a donor under conditions sufficient to induce uptake of the donor antigen; contacting a second sample comprising APCs obtained from the subject in need of or having received an organ transplant with a third-party antigen under conditions sufficient to induce uptake of the third-party antigen; and determining an antigen presenting index by determining a ratio of uptake of the donor antigen in the first sample to uptake of the third-party antigen in the second sample, wherein the ratio of greater than one indicates organ rejection and the APCs are monocytes or monocyte-derived cells.Type: ApplicationFiled: October 11, 2013Publication date: February 27, 2014Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Rakesh Sindhi, Chethan AshokKumar
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Publication number: 20130029372Abstract: Disclosed herein are methods for diagnosing or predicting B-cell rejection in a subject. In one example, for assessing transplant rejection, the method includes determining an antigen presenting index by comparing uptake of a donor antigen to uptake of a reference antigen in a biological sample obtained from the subject. In another example, for assessing GVHD, the method includes determining an antigen presenting index by comparing uptake of a recipient antigen to uptake of a reference antigen in a biological sample obtained from the subject.Type: ApplicationFiled: April 8, 2011Publication date: January 31, 2013Inventors: Rakesh Sindhi, Chethan Ashokkumar