Abstract: A method of determining the osteoarthritis, inflammatory arthritis or joint injury status in a subject, and a panel of test biomarkers for use in determining same is disclosed. In particular, the method comprise the steps of determining the expression levels of at least three test biomarkers in a sample of bodily fluid obtained from the subject; conducting a statistical analysis of the correlation and relative expression levels between the at least three biomarkers; calculating a statistical score based on the statistical analysis; and comparing the statistical score with reference statistical scores generated from at least three reference group expression profiles to predict, diagnose, monitor or determine one or more of osteoarthritis, inflammatory arthritis or joint injury. For both the method and panel the test biomarkers typically contains at least PIIANP. By analysis of the test biomarkers, the disease status of a subject may be determined.