Patents by Inventor Chew-Li Soh

Chew-Li Soh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240066060
    Abstract: This disclosure provides compositions and methods for the treatment of inherited metabolic disorders in a subject. Provided herein are compositions and methods to treat Lysosomal Storage Diseases (LSD) in a subject using myeloid cells.
    Type: Application
    Filed: April 27, 2023
    Publication date: February 29, 2024
    Inventors: Ibrahim John DOMIAN, Panagiotis DOUVARAS, Christoph PATSCH, Chew-Li SOH, Stephanie A. FISHER, Maya SRINIVAS, Jing WANG, Carlos PALADINI, Ashley E. LEPACK
  • Publication number: 20240060047
    Abstract: Provided herein are genetically engineered mammalian (e.g., human) cells that express one or more transgenes at a sustained expression level. Also provided are methods of making and using the cells.
    Type: Application
    Filed: October 9, 2020
    Publication date: February 22, 2024
    Applicant: BlueRock Therapeutics LP
    Inventors: Chew-Li SOH, Mark James TOMISHIMA, Dan Charles WILKINSON, Jr., Conor Brian McAULIFFE
  • Publication number: 20230227856
    Abstract: Strategies, systems, compositions, and methods for efficient production of knock-in cellular clones without reporter genes. An essential gene is targeted using a knock-in cassette that comprises an exogenous coding sequence for a gene product of interest (or “cargo sequence”) in frame with and downstream (3?) of an exogenous coding sequence or partial coding sequence of the essential gene. Undesired targeting events create a non-functional version of the essential gene, in essence a knock-out, which is “rescued” by correct integration of the knock-in cassette, which restores the essential gene coding region so that a functional gene product is produced and positions the cargo sequence in frame with and downstream of the essential gene coding sequence.
    Type: Application
    Filed: May 4, 2021
    Publication date: July 20, 2023
    Inventors: John Anthony Zuris, Carrie Marie Margulies, Chew-Li Soh, Peter Tonge, Mark James Tomishima, Conor Brian McAuliffe, Claudio Monetti