Abstract: Disclosed is a method for detecting nucleic acids by promoting branched DNA complex formation. The target nucleic acid detection signal and sensitivity can be dramatically increased by promoting self assembly of branched DNA between a plurality of amplified DNA targets and a single-chain oligonucleotide probe, by means of the integrated implementation of PCR, thermal denaturation and hybridization in a single reaction mixture.

Abstract: This invention relates to chips containing nucleic acid probes or primers and their use in methods to detect nucleic acid molecules. The invention includes DNA chips in contact with a thermocycler capable of automatically regulating the temperature, temperature cycle times, and number of temperature cycles of the chips to provide genetic diagnosis in one step.

Abstract: The disclosure relates to chips containing nucleic acid probes or primers and their use in methods to detect nucleic acid molecules of DNA viruses. The disclosure includes DNA chips with probes immobilized via a dendron-mediated linkage in contact with a thermocycler capable of automatically regulating the temperature, temperature cycle times, and number of temperature cycles of the chips to provide genetic diagnosis in one step.

Abstract: Disclosed is a method for detecting nucleic acids by promoting branched DNA complex formation. The target nucleic acid detection signal and sensitivity can be dramatically increased by promoting self assembly of branched DNA between a plurality of amplified DNA targets and a single-chain oligonucleotide probe, by means of the integrated implementation of PCR, thermal denaturation and hybridization in a single reaction mixture.

Abstract: The present invention relates to a VEGF polypeptide that binds to A?. The present invention also relates to a compound that sequesters A?. And conversely, the invention relates to a compound that sequesters VEGF. Thus, the present invention also relates to a method of screening for a compound that inhibits the binding of VEGF to A?, and thus relates to prevention and treatment of Alzheimer's Disease.

Abstract: The disclosure relates to chips containing nucleic acid probes or primers and their use in methods to detect nucleic acid molecules of DNA viruses. The disclosure includes DNA chips in contact with a thermocycler capable of automatically regulating the temperature, temperature cycle times, and number of temperature cycles of the chips to provide genetic diagnosis in one step.

Abstract: Disclosed is a method of using a compound as an inhibitor for ?-secretase, wherein the compound is capable of binding to the site within the ?-secretase recognition and/or cleavage site on amyloid precursor protein to specifically inhibit the ?-secretase's activity to cleave amyloid precursor protein with maintaining its activities to other substrates. Further, the present invention relates to inhibitors of amyloid precursor protein (APP) processing which bind to the site within the ?-secretase or ?-secretase cleavage and/or recognition site on amyloid precursor protein.

Abstract: The present invention relates to a VEGF polypeptide that binds to A?. The present invention also relates to a compound that sequesters A?. And conversely, the invention relates to a compound that sequesters VEGF. Thus, the present invention also relates to a method of screening for a compound that inhibits the binding of VEGF to A?, and thus relates to prevention and treatment of Alzheimer's Disease.

Abstract: Disclosed is a method of using a compound as an inhibitor for ?-secretase, wherein the compound is capable of binding to the site within the ?-secretase recognition and/or cleavage site on amyloid precursor protein to specifically inhibit the ?-secretase's activity to cleave amyloid precursor protein with maintaining its activities to other substrates. Further, the present invention relates to inhibitors of amyloid precursor protein (APP) processing which bind to the site within the ?-secretase or ?-secretase cleavage and/or recognition site on amyloid precursor protein.

Abstract: This invention relates to chips containing nucleic acid probes or primers and their use in methods to detect nucleic acid molecules. The invention includes DNA chips in contact with a thermocycler capable of automatically regulating the temperature, temperature cycle times, and number of temperature cycles of the chips to provide genetic diagnosis in one step.

Abstract: Disclosed are novel peptides inhibitory of the activity of vascular endothelial growth factor (VEGF) and their use in the treatment of angiogenesis-related diseases, including cancer. A combinatorial library of peptides consisting of six amino acid residues were chemically synthesize and, from the library, specific amino acid residues for each amino acid position were screened by comparing their inhibitory activity against VEGF binding to the cell surface receptor. The novel peptide sequences thus obtained bind to VEGF and block the binding of VEGF to its receptors present on the surface of vascular endothelial cells, thereby inhibiting the hormonal activity of VEGF. The peptides inhibit the angiogenesis induced by VEGF and human cancer cells. Also, the peptides inhibit growth and metastasis of human cancer cells transplanted to mice. Thus, the peptides can be used to treat angiogenesis-related diseases, including cancer, diabetic retinopathy, rheumatoid arthritis, etc.

Abstract: Disclosed is a method of using a compound as an inhibitor for ?-secretase, wherein the compound is capable of binding to the site within the ?-secretase recognition and/or cleavage site on amyloid precursor protein to specifically inhibit the ?-secretase's activity to cleave amyloid precursor protein with maintaining its activities to other substrates. Further, the present invention relates to inhibitors of amyloid precursor protein (APP) processing which bind to the site within the ?-secretase or ?-secretase cleavage and/or recognition site on amyloid precursor protein.

Abstract: The application discloses inhibitors of amyloid precursor protein (APP) processing which bind to ?-secretase and/or ?-secretase cleavage sites.

Abstract: The present invention relates to a VEGF polypeptide that binds to &bgr;-amyloid. The present invention also relates to a compound that sequesters &bgr;-amyloid. And conversely, the invention relates to a compound that sequesters VEGF. Thus, the present invention also relates to a method of screening for a compound that inhibits the binding of VEGF to &bgr;-amyloid, and thus relates to diagnosis and treatment of Alzheimer's Disease.