Patents by Inventor Chi-Chang Shieh

Chi-Chang Shieh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Endoplasmic reticulum-targeting nanovehicles and methods for use thereof
    Patent number: 10912843
    Abstract: A method for treating a disease caused by protein retention in the endoplasmic reticulum (ER) with a sarcoplasmic/endoplasmic reticulum calcium ATPase pump inhibitor encapsulated in a polymer nanoparticle. The polymer nanoparticle is surface-modified such that it is targeted to the ER. The inhibitor reduces protein retention in the ER and the encapsulation lowers side effects of the inhibitor, e.g., cytotoxicity, as compared to administering the inhibitor without encapsulation. Also disclosed is a pharmaceutical composition that can be used for carrying out the method. Further provided is a transgenic mouse carrying in its genome a heterologous nucleic acid that encodes an H338Y mutant gp91phox protein. The transgenic mouse can serve as a model for human chronic granulomatous disease.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: February 9, 2021
    Assignee: National Cheng Kung University
    Inventors: Chi-Chang Shieh, Chia-Liang Yen, Dar-Bin Shieh, Si-Tse Jiang
  • ENDOPLASMIC RETICULUM-TARGETING NANOVEHICLES AND METHODS FOR USE THEREOF
    Publication number: 20190307894
    Abstract: A method for treating a disease caused by protein retention in the endoplasmic reticulum (ER) with a sarcoplasmic/endoplasmic reticulum calcium ATPase pump inhibitor encapsulated in a polymer nanoparticle. The polymer nanoparticle is surface-modified such that it is targeted to the ER. The inhibitor reduces protein retention in the ER and the encapsulation lowers side effects of the inhibitor, e.g., cytotoxicity, as compared to administering the inhibitor without encapsulation. Also disclosed is a pharmaceutical composition that can be used for carrying out the method. Further provided is a transgenic mouse carrying in its genome a heterologous nucleic acid that encodes an H338Y mutant gp91phox protein. The transgenic mouse can serve as a model for human chronic granulomatous disease.
    Type: Application
    Filed: January 31, 2019
    Publication date: October 10, 2019
    Inventors: Chi-Chang Shieh, Chia-Liang Yen, Dar-Bin Shieh, Si-Tse Jiang
  • Method for enhancing leukocyte immune function
    Publication number: 20070003527
    Abstract: The present invention provides a method for enhancing the immune function of leukocytes in a subject, which comprises the steps of: (a) isolating leukocytes from the subject; (b) treating the leukocytes obtained from step (a) with an inhibitor of the endoplasmic reticulum calcium ion pump; and (c) administrating the treated leukocytes obtained from step (b) back to the subject. A pharmaceutical composition for enhancing the immune function of leukocytes in a subject and a method for preparing said pharmaceutical composition are also provided.
    Type: Application
    Filed: June 23, 2005
    Publication date: January 4, 2007
    Applicant: National Cheng Kung University
    Inventor: Chi-Chang Shieh