Abstract: The present invention is directed to ophthalmic devices that are loaded with therapeutic agent. The devices provide prolonged release of the therapeutic agent to the eye. The ophthalmic devices are typically formed of an ophthalmic material that is particularly desirable for the loading of therapeutic agent and/or the therapeutic agent is typically particularly desirable for loading to the ophthalmic material.

Abstract: The invention provides a thermoplastic polymer composition comprising a polyolefin polymer and a nucleating agent. The nucleating agent comprises a compound conforming to the structure of Formula (I) The invention also provides a series of compounds encompassed by the structure of Formula (I).

Abstract: The invention provides a thermoplastic polymer composition comprising a polyolefin polymer and a nucleating agent. The nucleating agent comprises a compound conforming to the structure of Formula (I) The invention also provides a series of compounds encompassed by the structure of Formula (I).

Abstract: A polyethylene article comprises crystalline polyethylene in an orthorhombic unit cell. The b-axes of the crystalline polyethylene are substantially aligned with the machine direction of the article. In particular, the Herman's index of the b-axes in the machine direction is greater than zero and greater than the Herman's indices of the b-axes in both the transverse and normal directions. The unique physical attributes exhibited by a polyethylene article having this new morphology are also described.

Abstract: The present invention is directed to an intraocular lens, an intraocular lens system and a method of producing and/or implanting the lens or system in an eye wherein at least one intraocular lens includes a coating that aids in resisting interlenticular opacification (ILO). The material of the coating is preferably hydrophilic or super-hydrophobic.

Abstract: The present invention is directed to an intraocular lens, an intraocular lens system and a method of producing and/or implanting the lens or system in an eye wherein at least one intraocular lens includes a coating that aids in resisting interlenticular opacification (ILO). The material of the coating is preferably hydrophilic or super-hydrophobic.

Abstract: The present invention is directed to an intraocular lens, an intraocular lens system and a method of producing and/or implanting the lens or system in an eye wherein at least one intraocular lens includes a coating that aids in resisting opacification (e.g., posterior capsule opacification (PCO), interlenticular opacification (ILO) or the like). The material of the coating is preferably hydrophilic or super-hydrophobic.

Abstract: One aspect of the present invention relates to aqueous surgical compositions comprising a sigma-1 receptor agonist. Another aspect of the present invention relates to methods of irrigating ocular tissues during an ophthalmic surgical procedure such as cataract surgery. Such methods comprise bathing the ocular tissues with a composition comprising a sigma-1 receptor agonist.

Abstract: The present invention is directed to an intraocular lens, an intraocular lens system and a method of producing and/or implanting the lens or system in an eye wherein at least one intraocular lens includes a coating that aids in resisting interlenticular opacification (ILO). The material of the coating is preferably hydrophilic or super-hydrophobic.

Abstract: The present invention is directed to ophthalmic devices that are loaded with therapeutic agent. The devices provide prolonged release of the therapeutic agent to the eye. The ophthalmic devices are typically formed of an ophthalmic material that is particularly desirable for the loading of therapeutic agent and/or the therapeutic agent is typically particularly desirable for loading to the ophthalmic material.

Abstract: The invention is a process for the preparation of crosslinked water-swellable polymer particles. First, an aqueous polymer solution containing a water-soluble polymer having at least one functional group or charge, is combined with aqueous medium. The aqueous polymer solution is then mixed under moderate agitation with an oil medium and an emulsifier to form an emulsion of droplets of the water-soluble polymer. A crosslinking agent capable of crosslinking the functional groups and/or charges in the water-soluble polymer is then added to the emulsion to form crosslinked water-swellable polymer particles. The invention also includes the particles formed by the process and aqueous dispersions containing the particles which are useful for administering to an individual. The particles of the invention are useful for implantation, soft tissue augmentation, and scaffolding to promote cell growth.

Abstract: A medical instrument and method is provided for defoaming or preventing formation of foam in blood during extracorporeal blood circulation. The method comprises durably coating hydrophobic blood-contact surfaces with a nontoxic, biocompatible surface-active defoaming agent.

Abstract: The invention is a process for the preparation of crosslinked water-swellable polymer particles. First, an aqueous polymer solution containing a water-soluble polymer having at least one functional group or charge, is combined with aqueous medium. The aqueous polymer solution is then mixed under moderate agitation with an oil medium and an emulsifier to form an emulsion of droplets of the water-soluble polymer. A crosslinking agent capable of crosslinking the functional groups and/or charges in the water-soluble polymer is then added to the emulsion to form crosslinked water-swellable polymer particles. The invention also includes the particles formed by the process and aqueous dispersions containing the particles which are useful for administering to an individual. The particles of the invention are useful for implantation, soft tissue augmentation, and scaffolding to promote cell growth.