Abstract: Small interfering RNAs (siRNA) having specific modification patterns to improve interference efficiencies thereof. The modification patterns each comprises a combination of 2?-O methyl modification, 2?-O-fluoro-modification, and phosphorothioate (PS) bonds at defined positions in the sense strand and anti-sense strand of each siRNA, and optionally 5? phosphate modifications.

Abstract: A modified small interfering RNA (siRNA) molecule comprising phosphorothioate (PS) intemucleotide linkages in the antisense strand for reducing off-target effects and methods and uses thereof. The siRNAs targeting Hypoxia Inducible Factor 1 Subunit Alpha (HIF1a) with high specificity and silencing efficiency.

Abstract: A substrate grinding tool is configured to remove material from a semiconductor substrate in a grinding operation. In the grinding operation, the substrate grinding tool uses a combination of mechanical grinding and a chemical etchant to remove material from the semiconductor substrate. The chemical etchant may be heated to a high temperature, which may increase the etch rate of the chemical etchant. The use of the combination of mechanical grinding and the chemical etchant may increase the grinding rate of the substrate grinding tool for grinding semiconductor substrates, may reduce surface roughness for semiconductor substrates that are processed by the substrate grinding tool, and/or may reduce surface damage for semiconductor substrates that are processed by the substrate grinding tool, among other examples.

Abstract: A circuit for driving output of a capacitive element between two voltage levels has at least one driver cell with a first switch pair connected in series between a first voltage source terminal and the capacitive element and a second switch pair connected in series between a second voltage source terminal and the capacitive element. One or more non-dissipative elements may be connected between a first common node of the first switch pair and a second common node of the second switch pair. Combinations of driver cell switches are activated and deactivated in sequences to provide step-wise transfer of energy to the capacitive element, subtracting from an input voltage, bypassing a driver cell, and adding to the input voltage. Switching stages to reach a high voltage output may be identical to but organized in reverse order from the switching stages to reach a low voltage output.

Abstract: The present disclosure relates to abrasive articles including conformable coatings, e.g. a hydrophobic coating, methods of making and polishing systems therefrom. The present disclosure provides an abrasive layer, having a hydrophobic exterior surface, including at least one of (i) a plurality of individual diamond particles and (ii) a plurality of engineered features having a conformable diamond layer and; a conformable hydrophobic layer in contact with and at least partially coating at least one of the plurality of individual diamond particles and the conformable diamond layer and, wherein the conformable hydrophobic layer includes diamond like glass and forms the hydrophobic exterior surface and the contact angle of the hydrophobic exterior surface is greater than 110 degrees.

Abstract: A conjugate comprising a cyclic peptide scaffold and one or more N-acetylgalactosamine (GalNAc) moieties. The conjugate may further carry a diagnostic or therapeutic agent for use in delivering the agent to liver cells. In some embodiments, the cyclic peptide may have 4-10 amino acid residues. The GalNAc moieties can be covalently bound to the cyclic peptide scaffold via a first linker and the agent can be covalently bound to the cyclic peptide scaffold via a second linker.

Abstract: A method for forming a polyurethane foam with reduced emissions is provided. The method includes a step of reacting a mixture comprising a polyol composition, an isocyanate composition, and a butylated triphenyl phosphate ester, The reaction forms a polyurethane foam. Characteristically, the butylated triphenyl phosphate ester is present in a sufficient amount to inhibit emission of propionaldehyde, formaldehyde, and acetaldehyde.

Abstract: A contamination detection and auto-cleaning equipment and a method using the same are provided. The contamination detection and auto-cleaning equipment includes a contamination detection device and an automatic cleaning device. The contamination detection device is configured for detecting a cleanliness of a sample container. The automatic cleaning device is configured for cleaning the sample container. The contamination detection device includes a light emitter, a detection-light receiver and a controller. The light emitter is configured for emitting an emission light, wherein the emission light becomes a detection light after traveling through the sample container. The detection-light receiver is configured for receiving the detection light to obtain a detection-light intensity. The controller is coupled to the light emitter and the detection-light receiver, and obtain the cleanliness of the sample container according to a variation of the detection-light intensity.

Abstract: A composition for forming a polyurethane foam is provided using polyol having a total unsaturation less than 0.04 meq/g, methylene diphenyl diisocyanate (MDI), and epoxidized soybean oil. The epoxidized soybean oil may comprise greater than about 5% by weight of the composition. A method for forming polyurethane foam using the aforementioned composition is also provided.

Abstract: A transparent conductive film comprises a substrate, a metal nanowire layer disposed on the substrate, and a water blocking protective layer, which has water absorbing particles and is disposed on the metal nanowire layer. The transparent conductive film has a first absorption peak in a 2750 cm?1 to 3000 cm?1 wavenumber region and a second absorption peak in a 3000 cm?1 to 3750 cm?1 wavenumber region using FTIR detection. A ratio of a maximum peak intensity of the second absorption peak to a maximum peak intensity of the first absorption peak ranges from 0.18 to 0.50, and a haze value of the transparent conductive film is 1.7% or less. The transparent conductive film can overcome the problems of poor bending resistance and visibility and can be appropriately applied to touch sensors due to bendability and high water blocking performance of the transparent conductive film.

Abstract: A circuit for driving the voltage of a capacitive element between two voltage levels has at least one driver cell with a first pair of switches connected in series between a first terminal of a voltage source and the capacitive element, and a second pair of switches connected in series between a second terminal of the voltage source and the capacitive element. A plurality of non-dissipative elements may be connected in parallel or in series between the first pair of switches and the second pair of switches. Combinations of switches from the driver cells may be activated and deactivated in a defined sequence to provide step-wise transfer of energy to the capacitive element. The defined sequence may have a switching pattern with a voltage change portion arranged to cause a change in an output voltage of the capacitive element driver during application thereof on the capacitive element driver.

Abstract: Provided are interfering RNAs (e.g., siRNAs) targeting SARS-CoV (e.g., the POL, Spike, Helicase, or Envelop gene thereof) and therapeutic uses thereof for inhibiting SARS-CoV infection and/or treating diseases associated with the infection (e.g., COVID-19).

Abstract: A device structure according to the present disclosure includes a conductive feature disposed in a first dielectric layer, a ferroelectric tunnel junction (FTJ) stack disposed over the conductive feature, a spacer disposed along sidewalls of the FTJ stack, a second dielectric layer disposed over the spacer and the FTJ stack, a second dielectric layer disposed over the spacer and the FTJ stack, and a contact via extending through the second dielectric layer. The FTJ stack includes a bottom electrode layer electrically coupled to the conductive feature, a ferroelectric layer over the bottom electrode layer, and a top electrode layer on the ferroelectric layer. The top electrode layer is formed of a conductive metal oxide.

Abstract: A circuit for driving the voltage of a capacitive element between two voltage levels has at least one driver cell with a first pair of switches connected in series between a first terminal of a voltage source and the capacitive element, and a second pair of switches connected in series between a second terminal of the voltage source and the capacitive element. A plurality of non-dissipative elements may be connected in parallel or in series between the first pair of switches and the second pair of switches. Combinations of switches from the driver cells may be activated and deactivated in a defined sequence to provide step-wise transfer of energy to the capacitive element. The defined sequence may have a switching pattern with a voltage change portion arranged to cause a change in an output voltage of the capacitive element driver during application thereof on the capacitive element driver.

Abstract: A mouse is provided. The mouse includes a casing, a circuit board, a micro switch base, and a micro switch. The casing includes a button. The circuit board is disposed in the casing. The micro switch base is disposed on the circuit board, and includes a plurality of first openings and a plurality of second openings. The micro switch is fixed on the micro switch base through at least one of the first openings, and electrically connected to the circuit board through the first openings or the second openings.

Abstract: A water quality monitoring device and a monitoring method thereof are provided. The water quality monitoring device includes a water tank, a first and a second optical detection devices and a control circuit. The water tank has an accommodating space to carry a liquid. The first optical detection device provides a first light to detect and obtain a first reference light intensity, a first scattered light intensity, and a first penetrating light intensity. The second optical detection device provides a second light to detect and obtain a second reference light intensity, a second scattered light intensity, and a second penetrating light intensity. The control circuit calculates a water quality detection value of the liquid based on the first reference light intensity, the first scattered light intensity, the first penetrating light intensity, the second reference light intensity, the second scattered light intensity, and the second penetrating light intensity.

Abstract: A light emitting device includes a substrate, multiple light emitting diodes disposed on the substrate and a light-reflecting resist. The light emitting diode has a first electrode and a second electrode, both of which are disposed on a first surface of the light emitting diode facing the substrate. The light-reflecting resist is disposed between the light emitting diodes and directly contacts a side surface of the light emitting diode. At least a portion of the light-reflecting resist is disposed between the first electrode and the second electrode.

Abstract: A circuit for driving the voltage of a capacitive element between two voltage levels has at least one driver cell with a first pair of switches connected in series between a first terminal of a voltage source and the capacitive element, and a second pair of switches connected in series between a second terminal of the voltage source and the capacitive element. One or more non-dissipative elements may be connected between the common node of the first pair of switches and the common node of the second pair of switches. Combinations of switches from the driver cells may be activated and deactivated in a defined sequence to provide step-wise transfer of energy to the capacitive element. In one sequence, switches in a selected driver cell may subtract a specified voltage from an input voltage, bypass the selected driver cell, and add the specified voltage to the input voltage.

Abstract: An on-cell touch display and a preparing method thereof are provided. The on-cell touch display includes a display panel and a touch sensor disposed on the display panel. The touch sensor includes a first conductive thin film, which is formed on the display panel; an insulating layer, which is formed on the first conductive thin film; a second conductive thin film, which is formed on the insulating layer; and a protective film, which is formed on the second conductive thin film; wherein the non-uniformity value of the first conductive thin film and the second conductive thin film is less than 15% respectively.